Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0509 | 0.0555 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0031 | 0.0385 | 0.0385 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0038 | 0.0688 | 0.0688 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0042 | 0.0837 | 0.0913 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0509 | 0.0509 |
Loa Loa (eye worm) | glutamate receptor | 0.0083 | 0.2561 | 0.2561 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0054 | 0.1344 | 0.169 |
Onchocerca volvulus | Metabotropic glutamate receptor homolog | 0.0034 | 0.0509 | 0.5 |
Onchocerca volvulus | Poor gastrulation protein homolog | 0.0034 | 0.0509 | 0.5 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0176 | 0.6506 | 0.6506 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0042 | 0.0837 | 0.0913 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0474 | 0.0474 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0031 | 0.0385 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0082 | 0.2515 | 0.3164 |
Leishmania major | cytochrome p450-like protein | 0.0031 | 0.0385 | 1 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.019 | 0.7113 | 0.8949 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0176 | 0.6506 | 0.6506 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0102 | 0.3396 | 0.3705 |
Loa Loa (eye worm) | glutamate receptor | 0.021 | 0.7948 | 0.7948 |
Echinococcus granulosus | GPCR family 3 C terminal | 0.0034 | 0.0509 | 0.0509 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0031 | 0.0385 | 0.0385 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0054 | 0.1344 | 0.1344 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0054 | 0.1344 | 0.1344 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0102 | 0.3396 | 0.4273 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.1344 | 0.1344 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0038 | 0.0688 | 0.0688 |
Brugia malayi | Cytochrome P450 family protein | 0.0031 | 0.0385 | 0.0484 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0082 | 0.2515 | 0.2515 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0036 | 0.0581 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0176 | 0.6506 | 0.7099 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0031 | 0.0385 | 0.0385 |
Echinococcus multilocularis | GPCR, family 3, C terminal | 0.0034 | 0.0509 | 0.0509 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0038 | 0.0688 | 0.0688 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0038 | 0.0688 | 0.0865 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0031 | 0.0385 | 1 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.021 | 0.7948 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0031 | 0.0385 | 0.0484 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0036 | 0.0581 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0031 | 0.0385 | 1 |
Brugia malayi | metabotropic GABA-B receptor subtype 2 | 0.0034 | 0.0509 | 0.064 |
Trypanosoma brucei | cytochrome P450, putative | 0.0031 | 0.0385 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0239 | 0.9165 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.