Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | cyclins, putative | 0.0049 | 0.0485 | 0.044 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0049 | 0.0485 | 1 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0169 | 0.2736 | 0.2428 |
Onchocerca volvulus | 0.0049 | 0.0485 | 0.5 | |
Trichomonas vaginalis | cyclin A, putative | 0.0049 | 0.0485 | 0.044 |
Trichomonas vaginalis | cyclins, putative | 0.0049 | 0.0485 | 0.044 |
Trichomonas vaginalis | cyclin B, putative | 0.0049 | 0.0485 | 0.044 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0049 | 0.0485 | 0.0351 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase/rotamase, putative | 0.0542 | 0.9754 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0485 | 0.0351 |
Schistosoma mansoni | cyclin B | 0.0049 | 0.0485 | 0.0351 |
Trichomonas vaginalis | cyclin D, putative | 0.0031 | 0.0139 | 0.0092 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0169 | 0.2736 | 0.2428 |
Trichomonas vaginalis | cyclin D, putative | 0.0031 | 0.0139 | 0.0092 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0169 | 0.2736 | 0.2428 |
Toxoplasma gondii | peptidylprolyl isomerase | 0.0542 | 0.9754 | 1 |
Leishmania major | peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative | 0.0542 | 0.9754 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0542 | 0.9754 | 1 |
Leishmania major | peptidyl-prolyl cis-trans isomerase, putative | 0.0169 | 0.2736 | 0.2428 |
Trichomonas vaginalis | cyclin B, putative | 0.0049 | 0.0485 | 0.044 |
Toxoplasma gondii | PPIC-type PPIASE domain-containing protein | 0.0169 | 0.2736 | 0.2805 |
Trichomonas vaginalis | cyclins, putative | 0.0049 | 0.0485 | 0.044 |
Entamoeba histolytica | cyclin, putative | 0.0049 | 0.0485 | 0.036 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0542 | 0.9754 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0031 | 0.0139 | 0.0092 |
Trichomonas vaginalis | cyclin B, putative | 0.0049 | 0.0485 | 0.044 |
Wolbachia endosymbiont of Brugia malayi | parvulin-like peptidyl-prolyl isomerase, PPID | 0.0169 | 0.2736 | 0.5 |
Trichomonas vaginalis | cyclins, putative | 0.0049 | 0.0485 | 0.044 |
Trichomonas vaginalis | cyclins, putative | 0.0031 | 0.0139 | 0.0092 |
Echinococcus multilocularis | cyclin B | 0.0049 | 0.0485 | 0.0351 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, putative | 0.0542 | 0.9754 | 1 |
Trichomonas vaginalis | cyclin B3, putative | 0.0031 | 0.0139 | 0.0092 |
Trichomonas vaginalis | rotamase, putative | 0.0542 | 0.9754 | 0.9753 |
Plasmodium falciparum | cyclin | 0.0031 | 0.0139 | 0.5 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0049 | 0.0485 | 0.0351 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0031 | 0.0139 | 0.0092 |
Echinococcus granulosus | cyclin B | 0.0049 | 0.0485 | 0.0351 |
Trichomonas vaginalis | cyclin B, putative | 0.0049 | 0.0485 | 0.044 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0485 | 0.0351 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 8.19 % | Inhibition of human ALK5 at 10 uM in presence of 1 microM ATP relative to control | ChEMBL. | 23294702 |
Inhibition (binding) | = 30.9 % | Inhibition of human P38alpha/MAPK at 10 uM in presence of 10 microM ATP | ChEMBL. | 23294702 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.