Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | peroxisome proliferator-activated receptor gamma | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | ecdysone induced protein 78C | peroxisome proliferator-activated receptor gamma | 477 aa | 447 aa | 28.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0009 | 0 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0009 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0009 | 0 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0009 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0009 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0009 | 0 | 0.5 |
Onchocerca volvulus | 0.0009 | 0 | 0.5 | |
Schistosoma mansoni | thyroid hormone receptor | 0.0009 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0009 | 0 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0009 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0009 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0009 | 0 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0009 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0009 | 0 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0009 | 0 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0009 | 0 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0009 | 0 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0009 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0009 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0009 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0009 | 0 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0009 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.1835 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1835 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0009 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0009 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0009 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0009 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0009 | 0 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0009 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0009 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0009 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0009 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1835 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0009 | 0 | 0.5 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.1835 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0009 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0009 | 0 | 0.5 |
Brugia malayi | ecdysteroid receptor | 0.0009 | 0 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0009 | 0 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0009 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0009 | 0 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0009 | 0 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0009 | 0 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0009 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0009 | 0 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0009 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 2600 nM | Maximal reporter activity against human Peroxisome proliferator activated receptor gamma Gal4 chimeric in transiently transfected CV-1 cells by functional assay. | ChEMBL. | 11720854 |
EC50 (functional) | = 2600 nM | Maximal reporter activity against human Peroxisome proliferator activated receptor gamma Gal4 chimeric in transiently transfected CV-1 cells by functional assay. | ChEMBL. | 11720854 |
Ki (binding) | = 620 nM | Binding affinity to human Peroxisome proliferator activated receptor gamma using scintillation proximity assay | ChEMBL. | 11720854 |
Ki (binding) | = 620 nM | Binding affinity to human Peroxisome proliferator activated receptor gamma using scintillation proximity assay | ChEMBL. | 11720854 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.