Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | Dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | hypothetical protein | 0.2185 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2185 | 0.5 | 0.5 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.2185 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2185 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
I50 (binding) | = 110000 M | Binding affinity against Dihydrofolate reductase of rat liver | ChEMBL. | 3973902 |
I50 (binding) | = 620000000 M | Inhibitory activity against Dihydrofolate reductase of E. coli | ChEMBL. | 7035668 |
I50 (binding) | = 11000000000000 M | Inhibition of rat liver Dihydrofolate reductase. | ChEMBL. | 7035668 |
IC50 (binding) | = 0.000000062 M | Inhibitory activity against Dihydrofolate reductase of E. coli | ChEMBL. | 7035668 |
IC50 (binding) | = 0.0011 M | Binding affinity against Dihydrofolate reductase of rat liver | ChEMBL. | 3973902 |
IC50 (binding) | = 0.0011 M | Inhibition of rat liver Dihydrofolate reductase. | ChEMBL. | 7035668 |
Ki (binding) | = 0.0000000098 M | Binding affinity against Dihydrofolate reductase of Escherichia coli | ChEMBL. | 3973902 |
Ki (binding) | = 9800000000 M | Binding affinity against Dihydrofolate reductase of Escherichia coli | ChEMBL. | 3973902 |
MIC (functional) | = 1000 | Relative invitro Antibacterial activity against Escherichia coli CN314 strain | ChEMBL. | 3973902 |
MIC (functional) | = 6 | Relative invitro Antibacterial activity against Staphylococcus aureus CN491 strain | ChEMBL. | 3973902 |
MIC (functional) | > 100 | Relative invitro Antibacterial activity against Proteus vulgaris CN329 strain | ChEMBL. | 3973902 |
MIC (functional) | = 300 | Relative invitro Antibacterial activity against Salmonella typhi CN512 strain | ChEMBL. | 3973902 |
MIC (functional) | = 1000 | Relative invitro Antibacterial activity against Escherichia coli CN314 strain | ChEMBL. | 3973902 |
Ratio (functional) | = 10 | Minimum inhibitory concentration of compound versus trimethoprim against Staphylococcus aureus CN 491 | ChEMBL. | 7035668 |
Ratio (functional) | > 100 | Minimum inhibitory concentration of compound versus trimethoprim against Proteus mirabilis S 2409 | ChEMBL. | 7035668 |
Ratio (functional) | > 100 | Minimum inhibitory concentration of compound versus trimethoprim against Proteus vulgaris CN 329 | ChEMBL. | 7035668 |
Ratio (functional) | = 300 | Minimum inhibitory concentration of compound versus trimethoprim against Salmonella typhi CN 512 | ChEMBL. | 7035668 |
Ratio (functional) | = 1000 | Minimum inhibitory concentration of compound versus trimethoprim against Shigella dysentariae CN 1513 | ChEMBL. | 7035668 |
Ratio (functional) | = 1000 | Minimum inhibitory concentration of compound versus trimethoprim against Escherichia coli CN 314 | ChEMBL. | 7035668 |
Ratio (functional) | > 1000 | Minimum inhibitory concentration of compound versus trimethoprim against Klebsiella pneumoniae CN 3632 | ChEMBL. | 7035668 |
Ratio (functional) | = 1000 | Minimum inhibitory concentration of compound versus trimethoprim against Enterobacter aerogenes 2200/86 | ChEMBL. | 7035668 |
Ratio (functional) | = 10 | Minimum inhibitory concentration of compound versus trimethoprim against Staphylococcus aureus CN 491 | ChEMBL. | 7035668 |
Ratio (functional) | > 100 | Minimum inhibitory concentration of compound versus trimethoprim against Proteus mirabilis S 2409 | ChEMBL. | 7035668 |
Ratio (functional) | > 100 | Minimum inhibitory concentration of compound versus trimethoprim against Proteus vulgaris CN 329 | ChEMBL. | 7035668 |
Ratio (functional) | = 300 | Minimum inhibitory concentration of compound versus trimethoprim against Salmonella typhi CN 512 | ChEMBL. | 7035668 |
Ratio (functional) | = 1000 | Minimum inhibitory concentration of compound versus trimethoprim against Escherichia coli CN 314 | ChEMBL. | 7035668 |
Ratio (functional) | > 1000 | Minimum inhibitory concentration of compound versus trimethoprim against Klebsiella pneumoniae CN 3632 | ChEMBL. | 7035668 |
Ratio (functional) | = 1000 | Minimum inhibitory concentration of compound versus trimethoprim against Shigella dysentariae CN 1513 | ChEMBL. | 7035668 |
Ratio (functional) | = 1000 | Minimum inhibitory concentration of compound versus trimethoprim against Enterobacter aerogenes 2200/86 | ChEMBL. | 7035668 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.