Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | lipase | 0.0125 | 0.8762 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.3021 | 0.3447 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0053 | 0.3021 | 0.1131 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0111 | 0.7665 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0053 | 0.3021 | 0.3447 |
Plasmodium falciparum | glutathione reductase | 0.0044 | 0.2288 | 1 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0125 | 0.8762 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0044 | 0.2288 | 1 |
Onchocerca volvulus | 0.0125 | 0.8762 | 0.5 | |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0111 | 0.7665 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.01 | 0.6774 | 0.8837 |
Trypanosoma brucei | trypanothione reductase | 0.0044 | 0.2288 | 0.2611 |
Trypanosoma brucei | lipase domain protein, putative | 0.0125 | 0.8762 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.3021 | 0.3021 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.01 | 0.6774 | 0.8837 |
Leishmania major | hypothetical protein, conserved | 0.0125 | 0.8762 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0111 | 0.7665 | 1 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0125 | 0.8762 | 1 |
Leishmania major | trypanothione reductase | 0.0044 | 0.2288 | 0.2611 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.3021 | 0.3447 |
Brugia malayi | Thioredoxin reductase | 0.0044 | 0.2288 | 0.2611 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0044 | 0.2335 | 0.2665 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0125 | 0.8762 | 1 |
Brugia malayi | Lipase family protein | 0.0125 | 0.8762 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0111 | 0.7665 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.3021 | 0.3447 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0044 | 0.2288 | 1 |
Brugia malayi | glutathione reductase | 0.0044 | 0.2288 | 0.2611 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.3021 | 0.3021 |
Plasmodium vivax | glutathione reductase, putative | 0.0044 | 0.2288 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.01 | 0.6774 | 0.8837 |
Mycobacterium tuberculosis | Probable reductase | 0.01 | 0.6774 | 0.8837 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0125 | 0.8762 | 1 |
Trypanosoma brucei | lipase domain protein, putative | 0.0125 | 0.8762 | 1 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0125 | 0.8762 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.3021 | 0.3021 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.3021 | 0.3447 |
Plasmodium falciparum | thioredoxin reductase | 0.0044 | 0.2288 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.01 | 0.6774 | 0.8837 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0044 | 0.2288 | 0.2985 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0044 | 0.2288 | 0.2611 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.01 | 0.6774 | 0.8837 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0044 | 0.2335 | 0.2665 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0125 | 0.8762 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 53 % | Cytotoxicity against human MCF7 cells assessed as reduction in cell viability at 100 uM after 72 hrs by Alamar blue assay | ChEMBL. | 23252648 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.