Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Xanthine dehydrogenase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Trichomonas vaginalis | xanthine dehydrogenase, putative | Get druggable targets OG5_127252 | All targets in OG5_127252 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (large chain) | Get druggable targets OG5_127252 | All targets in OG5_127252 |
Trichomonas vaginalis | aldehyde oxidase, putative | Get druggable targets OG5_127252 | All targets in OG5_127252 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 | Get druggable targets OG5_127252 | All targets in OG5_127252 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | Get druggable targets OG5_127252 | All targets in OG5_127252 |
Trichomonas vaginalis | xanthine dehydrogenase, putative | Get druggable targets OG5_127252 | All targets in OG5_127252 |
Mycobacterium ulcerans | carbon monoxide dehydrogenase | Get druggable targets OG5_127252 | All targets in OG5_127252 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.001 | 0.0016 | 0.0323 |
Echinococcus multilocularis | Immunoglobulin | 0.001 | 0.0016 | 0.0323 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase small chain CoxS | 0.004 | 0.1532 | 0.0568 |
Treponema pallidum | hypothetical protein | 0.0034 | 0.1235 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0013 | 0.0202 | 0.0272 |
Echinococcus granulosus | neuroglian | 0.0012 | 0.0139 | 0.2877 |
Echinococcus granulosus | roundabout 2 | 0.0019 | 0.0482 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0202 | 0.0272 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | 0.0099 | 0.4468 | 0.618 |
Schistosoma mansoni | cell adhesion molecule | 0.0017 | 0.0359 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0202 | 0.0272 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase medium chain CoxM | 0.0071 | 0.3067 | 0.3502 |
Echinococcus multilocularis | Immunoglobulin | 0.001 | 0.0016 | 0.0323 |
Echinococcus multilocularis | neuroglian | 0.0012 | 0.0139 | 0.2877 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0296 | 0.0399 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0016 | 0.0021 |
Echinococcus granulosus | Immunoglobulin | 0.001 | 0.0016 | 0.0323 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0147 | 0.6911 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0173 | 0.0233 |
Schistosoma mansoni | vesicular amine transporter | 0.001 | 0.0016 | 0.0434 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0016 | 0.0021 |
Brugia malayi | hypothetical protein | 0.0013 | 0.0202 | 0.0272 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0013 | 0.0173 | 0.3583 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0296 | 0.0399 |
Echinococcus granulosus | twitchin | 0.0012 | 0.0139 | 0.2877 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0158 | 0.7427 | 1 |
Echinococcus granulosus | defective proboscis extension response | 0.001 | 0.0016 | 0.0323 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0202 | 0.0272 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | 0.0062 | 0.2636 | 0.2678 |
Schistosoma mansoni | nephrin | 0.0016 | 0.0325 | 0.9052 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.001 | 0.0016 | 0.0434 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 | 0.0099 | 0.4468 | 0.618 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.001 | 0.0016 | 0.0434 |
Echinococcus multilocularis | roundabout 2 | 0.0019 | 0.0482 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0016 | 0.0021 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0013 | 0.0202 | 0.0272 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase small chain CoxS | 0.004 | 0.1532 | 0.0568 |
Treponema pallidum | quinoline 2-oxidoreductase | 0.0033 | 0.1195 | 0.8682 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (medium chain) | 0.0071 | 0.3067 | 0.5229 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 | 0.0071 | 0.3067 | 0.3502 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0158 | 0.7427 | 1 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (large chain) | 0.0099 | 0.4468 | 1 |
Mycobacterium ulcerans | carbon monoxide dehydrogenase | 0.0139 | 0.6466 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.4 uM | Inhibition of bovine xanthine oxidase-mediated uric acid production after 30 mins by spectrophotometric analysis | ChEMBL. | 23265878 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.