Detailed information for compound 1729621

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 365.406 | Formula: C19H15N3O3S
  • H donors: 2 H acceptors: 2 LogP: 4.92 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(c(c1)c1csc(n1)N/N=C/c1cc2c(o1)cccc2)O
  • InChi: 1S/C19H15N3O3S/c1-24-13-6-7-17(23)15(9-13)16-11-26-19(21-16)22-20-10-14-8-12-4-2-3-5-18(12)25-14/h2-11,23H,1H3,(H,21,22)/b20-10+
  • InChiKey: SKWVUCORPMGQPR-KEBDBYFISA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus peptide allatostatin:somatostatin 0.0563 0.4099 0.5615
Loa Loa (eye worm) hypothetical protein 0.0065 0.0197 0.0252
Schistosoma mansoni hypothetical protein 0.0059 0.0156 0.0156
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0145 0.0828 0.1134
Echinococcus multilocularis G-protein coupled receptor, putative 0.0563 0.4099 0.5615
Schistosoma mansoni hypothetical protein 0.0563 0.4099 0.4099
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0065 0.0197 0.0252
Loa Loa (eye worm) hypothetical protein 0.0563 0.4099 0.5246
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0563 0.4099 0.5615
Onchocerca volvulus 0.0131 0.0718 0.0919
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0065 0.0197 0.027
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0563 0.4099 0.4099
Brugia malayi PAN domain containing protein 0.0113 0.0575 0.0736
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0065 0.0197 0.027
Loa Loa (eye worm) hypothetical protein 0.0563 0.4099 0.5246
Echinococcus multilocularis rhodopsin orphan GPCR 0.0563 0.4099 0.5615
Echinococcus multilocularis neuropeptide receptor 0.0721 0.5334 0.7308
Schistosoma mansoni nAChR subunit 0.0065 0.0197 0.0197
Schistosoma mansoni cercarial elastase (S01 family) 0.0145 0.0828 0.0828
Loa Loa (eye worm) hypothetical protein 0.0563 0.4099 0.5246
Echinococcus granulosus rhodopsin orphan GPCR 0.0563 0.4099 0.5615
Schistosoma mansoni opsin-like receptor 0.0563 0.4099 0.4099
Schistosoma mansoni hypothetical protein 0.0145 0.0828 0.0828
Brugia malayi Trypsin family protein 0.0145 0.0828 0.1059
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0563 0.4099 0.5615
Brugia malayi hypothetical protein 0.0563 0.4099 0.5246
Loa Loa (eye worm) hypothetical protein 0.0054 0.0111 0.0143
Onchocerca volvulus 0.0113 0.0575 0.0736
Echinococcus multilocularis g protein coupled receptor 0.0563 0.4099 0.5615
Echinococcus multilocularis rhodopsin orphan GPCR 0.0563 0.4099 0.5615
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0563 0.4099 0.4099
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0065 0.0197 0.0252
Schistosoma mansoni cercarial elastase (S01 family) 0.0145 0.0828 0.0828
Loa Loa (eye worm) hypothetical protein 0.0563 0.4099 0.5246
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0065 0.0197 0.0252
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0563 0.4099 0.5615
Loa Loa (eye worm) hypothetical protein 0.0563 0.4099 0.5246
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0563 0.4099 0.5246
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0563 0.4099 0.5246
Onchocerca volvulus 0.0113 0.0575 0.0736
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0095 0.0439 0.0601
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0065 0.0197 0.0252
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0563 0.4099 0.5246
Loa Loa (eye worm) hypothetical protein 0.0065 0.0197 0.0252
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.001 0.001
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0203 0.1277 0.1277
Echinococcus multilocularis G protein coupled receptor 139 0.0721 0.5334 0.7308
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0563 0.4099 0.5615
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0563 0.4099 0.5615
Echinococcus granulosus neuropeptide Y receptor 0.0563 0.4099 0.5615
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0065 0.0197 0.027
Brugia malayi hypothetical protein 0.0563 0.4099 0.5246
Schistosoma mansoni nAChR subunit 0.0065 0.0197 0.0197
Echinococcus granulosus somatostatin receptor 0.0563 0.4099 0.5615
Loa Loa (eye worm) hypothetical protein 0.0131 0.0718 0.0919
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0145 0.0828 0.0828
Brugia malayi CUB domain containing protein 0.0043 0.003 0.0039
Echinococcus granulosus glycine receptor subunit beta 0.0065 0.0197 0.027
Loa Loa (eye worm) PAN domain-containing protein 0.0113 0.0575 0.0736
Brugia malayi PAN domain containing protein 0.0113 0.0575 0.0736
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0563 0.4099 0.4099
Onchocerca volvulus 0.0131 0.0718 0.0919
Toxoplasma gondii PAN domain-containing protein 0.0922 0.6905 1
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0145 0.0828 0.1134
Loa Loa (eye worm) hypothetical protein 0.0563 0.4099 0.5246
Brugia malayi Cation transporter family protein 0.0065 0.0197 0.0252
Loa Loa (eye worm) hypothetical protein 0.0219 0.1404 0.1797
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0145 0.0828 0.1134
Onchocerca volvulus 0.0113 0.0575 0.0736
Echinococcus multilocularis neuropeptides capa receptor 0.0973 0.7299 1
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0065 0.0197 0.027
Loa Loa (eye worm) hypothetical protein 0.0203 0.1277 0.1635
Brugia malayi putative neuropeptide receptor NPR1 0.0563 0.4099 0.5246
Loa Loa (eye worm) hypothetical protein 0.0563 0.4099 0.5246
Brugia malayi hypothetical protein 0.0563 0.4099 0.5246
Onchocerca volvulus 0.0563 0.4099 0.5246
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0095 0.0439 0.0601
Brugia malayi hypothetical protein 0.0041 0.001 0.0013
Onchocerca volvulus 0.0563 0.4099 0.5246
Schistosoma mansoni histamine h1 receptor 0.0563 0.4099 0.4099
Echinococcus granulosus glycoprotein Antigen 5 0.0145 0.0828 0.1134
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0065 0.0197 0.0252
Schistosoma mansoni cercarial elastase (S01 family) 0.0145 0.0828 0.0828
Loa Loa (eye worm) hypothetical protein 0.0065 0.0197 0.0252
Loa Loa (eye worm) hypothetical protein 0.0203 0.1277 0.1635
Echinococcus multilocularis neuropeptide Y receptor 0.0563 0.4099 0.5615
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0145 0.0828 0.0828
Echinococcus multilocularis neuropeptide s receptor 0.0563 0.4099 0.5615
Loa Loa (eye worm) hypothetical protein 0.0065 0.0197 0.0252
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0065 0.0197 0.027
Loa Loa (eye worm) LGC-31 protein 0.0065 0.0197 0.0252
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0563 0.4099 0.5615
Brugia malayi hypothetical protein 0.0563 0.4099 0.5246
Brugia malayi hypothetical protein 0.0563 0.4099 0.5246
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0065 0.0197 0.027
Loa Loa (eye worm) hypothetical protein 0.0563 0.4099 0.5246
Onchocerca volvulus 0.0113 0.0575 0.0736
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0095 0.0439 0.0439
Echinococcus multilocularis transmembrane protease serine 3 0.0145 0.0828 0.1134
Echinococcus granulosus voltage dependent calcium channel 0.0095 0.0439 0.0601
Schistosoma mansoni biogenic amine receptor 0.0563 0.4099 0.4099
Brugia malayi AKH receptor 0.0563 0.4099 0.5246
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0065 0.0197 0.027
Schistosoma mansoni cercarial elastase (S01 family) 0.0145 0.0828 0.0828
Loa Loa (eye worm) hypothetical protein 0.0065 0.0197 0.0252
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0065 0.0197 0.0252
Echinococcus granulosus transmembrane protease serine 3 0.0145 0.0828 0.1134
Onchocerca volvulus 0.0145 0.0828 0.1059
Brugia malayi PAN domain containing protein 0.0113 0.0575 0.0736
Onchocerca volvulus 0.0145 0.0828 0.1059
Schistosoma mansoni nAChR subunit 0.0065 0.0197 0.0197
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0145 0.0828 0.1134
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0563 0.4099 0.4099
Echinococcus multilocularis allatostatin A receptor 0.0563 0.4099 0.5615
Echinococcus granulosus neuropeptide receptor 0.0721 0.5334 0.7308
Loa Loa (eye worm) hypothetical protein 0.0563 0.4099 0.5246
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0065 0.0197 0.0252
Schistosoma mansoni cercarial elastase (S01 family) 0.0145 0.0828 0.0828
Loa Loa (eye worm) hypothetical protein 0.0563 0.4099 0.5246
Loa Loa (eye worm) hypothetical protein 0.1038 0.7812 1
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0065 0.0197 0.0197
Brugia malayi Cation transporter family protein 0.0203 0.1277 0.1635
Echinococcus multilocularis rhodopsin orphan GPCR 0.0563 0.4099 0.5615
Brugia malayi Protein kinase domain containing protein 0.0223 0.1438 0.184
Loa Loa (eye worm) hypothetical protein 0.0563 0.4099 0.5246
Schistosoma mansoni voltage-gated cation channel 0.0095 0.0439 0.0439
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0065 0.0197 0.0252
Schistosoma mansoni hypothetical protein 0.0041 0.001 0.001
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0563 0.4099 0.4099
Schistosoma mansoni amine GPCR 0.0563 0.4099 0.4099
Echinococcus multilocularis serotonin receptor 0.0563 0.4099 0.5615
Brugia malayi hypothetical protein 0.0563 0.4099 0.5246
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0563 0.4099 0.5615
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0095 0.0439 0.0439
Onchocerca volvulus 0.0113 0.0575 0.0736
Brugia malayi PAN domain containing protein 0.0113 0.0575 0.0736
Onchocerca volvulus 0.0065 0.0197 0.0252
Loa Loa (eye worm) trypsin family protein 0.0145 0.0828 0.1059
Loa Loa (eye worm) hypothetical protein 0.0563 0.4099 0.5246
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0065 0.0197 0.0197
Onchocerca volvulus 0.0203 0.1277 0.1635
Schistosoma mansoni biogenic amine (5HT) receptor 0.0563 0.4099 0.4099
Loa Loa (eye worm) hypothetical protein 0.0177 0.108 0.1382
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0111 0.0143
Schistosoma mansoni cercarial elastase (S01 family) 0.0145 0.0828 0.0828
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0065 0.0197 0.0252
Echinococcus multilocularis voltage dependent calcium channel 0.0095 0.0439 0.0601
Brugia malayi neuropeptide F receptor 0.0563 0.4099 0.5246
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0165 0.0979 0.0979
Loa Loa (eye worm) hypothetical protein 0.0563 0.4099 0.5246
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0563 0.4099 0.4099
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0041 0.0009 0.0012
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0563 0.4099 0.5615
Loa Loa (eye worm) hypothetical protein 0.0563 0.4099 0.5246
Loa Loa (eye worm) hypothetical protein 0.0563 0.4099 0.5246
Schistosoma mansoni nAChR subunit 0.0065 0.0197 0.0197
Schistosoma mansoni neuropeptide f receptor 76f 0.0563 0.4099 0.4099
Onchocerca volvulus 0.0219 0.1404 0.1797
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0145 0.0828 0.0828
Echinococcus multilocularis Mastin 0.0145 0.0828 0.1134
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0563 0.4099 0.5615
Loa Loa (eye worm) hypothetical protein 0.0113 0.0575 0.0736
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0563 0.4099 0.5615
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0065 0.0197 0.0252
Onchocerca volvulus 0.0131 0.0718 0.0919
Loa Loa (eye worm) hypothetical protein 0.0563 0.4099 0.5246
Echinococcus granulosus 7tm_1 domain containing protein 0.0563 0.4099 0.5615
Brugia malayi PAN domain containing protein 0.0113 0.0575 0.0736
Brugia malayi Dopamine receptor protein 2 0.0563 0.4099 0.5246
Brugia malayi RE15519p 0.0563 0.4099 0.5246
Onchocerca volvulus 0.0131 0.0718 0.0919
Loa Loa (eye worm) hypothetical protein 0.0563 0.4099 0.5246
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0563 0.4099 0.5615
Echinococcus granulosus tm gpcr rhodopsin 0.0563 0.4099 0.5615
Loa Loa (eye worm) hypothetical protein 0.0065 0.0197 0.0252
Echinococcus multilocularis glycine receptor subunit beta 0.0065 0.0197 0.027
Schistosoma mansoni adenoreceptor 0.0563 0.4099 0.4099
Schistosoma mansoni cercarial elastase (S01 family) 0.0145 0.0828 0.0828
Loa Loa (eye worm) hypothetical protein 0.0563 0.4099 0.5246
Brugia malayi Melatonin receptor type 1A 0.0563 0.4099 0.5246
Brugia malayi Trypsin family protein 0.0145 0.0828 0.1059
Loa Loa (eye worm) hypothetical protein 0.0065 0.0197 0.0252
Brugia malayi hypothetical protein 0.0563 0.4099 0.5246
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0065 0.0197 0.0252
Echinococcus granulosus neuropeptide s receptor 0.0563 0.4099 0.5615
Entamoeba histolytica hypothetical protein 0.0041 0.001 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0563 0.4099 0.4099
Loa Loa (eye worm) PAN domain-containing protein 0.0113 0.0575 0.0736
Brugia malayi Dopamine receptor protein 1 0.0563 0.4099 0.5246
Loa Loa (eye worm) hypothetical protein 0.0563 0.4099 0.5246
Brugia malayi neuropeptide F receptor 0.0563 0.4099 0.5246
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0065 0.0197 0.027
Loa Loa (eye worm) hypothetical protein 0.0065 0.0197 0.0252
Echinococcus granulosus alpha 1A adrenergic receptor 0.0563 0.4099 0.5615
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.1038 0.7812 0.7812
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0563 0.4099 0.4099
Loa Loa (eye worm) TYRA-2 protein 0.0563 0.4099 0.5246
Schistosoma mansoni hypothetical protein 0.0131 0.0718 0.0718
Loa Loa (eye worm) hypothetical protein 0.0145 0.0828 0.1059
Loa Loa (eye worm) hypothetical protein 0.0563 0.4099 0.5246
Loa Loa (eye worm) hypothetical protein 0.0113 0.0575 0.0736
Echinococcus granulosus g protein coupled receptor 0.0563 0.4099 0.5615
Loa Loa (eye worm) hypothetical protein 0.0563 0.4099 0.5246
Loa Loa (eye worm) hypothetical protein 0.0113 0.0575 0.0736
Brugia malayi larval opioid receptor 0.0563 0.4099 0.5246
Loa Loa (eye worm) hypothetical protein 0.0563 0.4099 0.5246
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0095 0.0439 0.0601
Echinococcus multilocularis fmrfamide receptor 0.0563 0.4099 0.5615
Brugia malayi putative neuropeptide receptor 0.0563 0.4099 0.5246
Echinococcus granulosus tm gpcr rhodopsin 0.0563 0.4099 0.5615
Loa Loa (eye worm) hypothetical protein 0.0563 0.4099 0.5246
Schistosoma mansoni biogenic amine (5HT) receptor 0.0563 0.4099 0.4099
Loa Loa (eye worm) hypothetical protein 0.0563 0.4099 0.5246
Brugia malayi GnHR receptor homolog 0.0563 0.4099 0.5246
Echinococcus multilocularis g protein coupled receptor 0.0563 0.4099 0.5615
Echinococcus granulosus rhodopsin orphan GPCR 0.0563 0.4099 0.5615
Brugia malayi Trypsin family protein 0.0145 0.0828 0.1059
Schistosoma mansoni biogenic amine receptor 0.0563 0.4099 0.4099
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0563 0.4099 0.5246
Onchocerca volvulus 0.0563 0.4099 0.5246
Schistosoma mansoni hypothetical protein 0.0145 0.0828 0.0828
Schistosoma mansoni neuropeptide receptor 0.0721 0.5334 0.5334
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0563 0.4099 0.5246
Echinococcus granulosus rhodopsin orphan GPCR 0.0563 0.4099 0.5615
Loa Loa (eye worm) hypothetical protein 0.0563 0.4099 0.5246
Echinococcus granulosus biogenic amine 5HT receptor 0.0563 0.4099 0.5615
Loa Loa (eye worm) ACC-1 protein 0.0065 0.0197 0.0252
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0563 0.4099 0.4099
Loa Loa (eye worm) hypothetical protein 0.0563 0.4099 0.5246
Loa Loa (eye worm) hypothetical protein 0.0223 0.1438 0.184
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0065 0.0197 0.0252
Schistosoma mansoni neuropeptide receptor 0.0563 0.4099 0.4099
Brugia malayi G protein-coupled receptor F59B2.13 0.0563 0.4099 0.5246
Onchocerca volvulus 0.0563 0.4099 0.5246
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0065 0.0197 0.0197
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0065 0.0197 0.027
Loa Loa (eye worm) hypothetical protein 0.0113 0.0575 0.0736
Loa Loa (eye worm) hypothetical protein 0.0563 0.4099 0.5246
Echinococcus multilocularis enteropeptidase 0.0145 0.0828 0.1134
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0095 0.0439 0.0601
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0203 0.1277 0.1277
Brugia malayi Dopamine receptor 0.0563 0.4099 0.5246
Loa Loa (eye worm) hypothetical protein 0.0043 0.003 0.0039
Brugia malayi G-protein coupled receptor 0.0563 0.4099 0.5246
Echinococcus multilocularis neuropeptide Y receptor 0.0563 0.4099 0.5615
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0145 0.0828 0.0828
Loa Loa (eye worm) hypothetical protein 0.0563 0.4099 0.5246
Loa Loa (eye worm) PAN domain-containing protein 0.0113 0.0575 0.0736
Loa Loa (eye worm) hypothetical protein 0.0065 0.0197 0.0252
Brugia malayi Trypsin family protein 0.1038 0.7812 1
Schistosoma mansoni neuropeptide receptor 0.0563 0.4099 0.4099
Loa Loa (eye worm) hypothetical protein 0.0563 0.4099 0.5246
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0563 0.4099 0.4099
Loa Loa (eye worm) melatonin receptor type 1A 0.0563 0.4099 0.5246
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0065 0.0197 0.0252
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0563 0.4099 0.5615
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0563 0.4099 0.5615
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0563 0.4099 0.5615
Toxoplasma gondii kringle domain-containing protein 0.0223 0.1438 0.1363
Loa Loa (eye worm) PAN domain-containing protein 0.0113 0.0575 0.0736
Brugia malayi hypothetical protein 0.0145 0.0828 0.1059
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0095 0.0439 0.0601
Schistosoma mansoni opsin-like receptor 0.0563 0.4099 0.4099
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0111 0.0143
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0563 0.4099 0.4099
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0563 0.4099 0.5615
Echinococcus granulosus nAChR subunit 0.0065 0.0197 0.027
Trypanosoma cruzi hypothetical protein, conserved 0.0223 0.1438 1
Echinococcus multilocularis g protein coupled receptor 0.0563 0.4099 0.5615
Loa Loa (eye worm) hypothetical protein 0.0563 0.4099 0.5246
Onchocerca volvulus 0.0563 0.4099 0.5246
Onchocerca volvulus 0.0893 0.6677 0.8547
Brugia malayi PAN domain containing protein 0.0113 0.0575 0.0736
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.001 0.0014
Echinococcus multilocularis serotonin receptor 0.0563 0.4099 0.5615
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0095 0.0439 0.0601
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0065 0.0197 0.0252
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0563 0.4099 0.4099
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0563 0.4099 0.5246
Onchocerca volvulus 0.0563 0.4099 0.5246
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0563 0.4099 0.4099
Schistosoma mansoni cercarial elastase (S01 family) 0.0145 0.0828 0.0828
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0563 0.4099 0.5246
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0563 0.4099 0.5246
Schistosoma mansoni opsin-like receptor 0.0563 0.4099 0.4099
Echinococcus multilocularis nAChR subunit 0.0065 0.0197 0.027
Loa Loa (eye worm) hypothetical protein 0.0065 0.0197 0.0252
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0563 0.4099 0.5615
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0065 0.0197 0.027
Onchocerca volvulus 0.0563 0.4099 0.5246
Echinococcus granulosus g-protein coupled receptor 0.0563 0.4099 0.5615
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0563 0.4099 0.5615
Echinococcus multilocularis neuropeptide FF receptor 2 0.0563 0.4099 0.5615
Loa Loa (eye worm) hypothetical protein 0.0043 0.003 0.0039
Loa Loa (eye worm) DOMON domain-containing protein 0.0131 0.0718 0.0919
Mycobacterium ulcerans hypothetical protein 0.0145 0.0828 0.5
Schistosoma mansoni nAChR subunit 0.0065 0.0197 0.0197
Brugia malayi G-protein coupled receptor 0.0563 0.4099 0.5246
Loa Loa (eye worm) hypothetical protein 0.0113 0.0575 0.0736
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0065 0.0197 0.027
Brugia malayi hypothetical protein 0.0563 0.4099 0.5246
Loa Loa (eye worm) hypothetical protein 0.0563 0.4099 0.5246
Echinococcus granulosus tachykinin peptides receptor 99D 0.0563 0.4099 0.5615
Echinococcus granulosus tissue type plasminogen activator 0.0223 0.1438 0.197
Brugia malayi follicle stimulating hormone receptor 0.0563 0.4099 0.5246
Loa Loa (eye worm) hypothetical protein 0.0563 0.4099 0.5246
Echinococcus granulosus serotonin receptor 0.0563 0.4099 0.5615
Brugia malayi hypothetical protein 0.0563 0.4099 0.5246
Echinococcus multilocularis rhodopsin orphan GPCR 0.0563 0.4099 0.5615
Onchocerca volvulus 0.0113 0.0575 0.0736
Loa Loa (eye worm) hypothetical protein 0.0563 0.4099 0.5246
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0095 0.0439 0.0562
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0563 0.4099 0.5246
Schistosoma mansoni nAChR subunit 0.0065 0.0197 0.0197
Echinococcus multilocularis glycine receptor subunit beta 0.0065 0.0197 0.027
Entamoeba histolytica hypothetical protein 0.0041 0.001 1
Brugia malayi PAN domain containing protein 0.0113 0.0575 0.0736
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0065 0.0197 0.0252
Toxoplasma gondii PAN domain-containing protein 0.0922 0.6905 1
Onchocerca volvulus 0.0113 0.0575 0.0736
Onchocerca volvulus 0.0131 0.0718 0.0919
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0065 0.0197 0.0252
Loa Loa (eye worm) hypothetical protein 0.0113 0.0575 0.0736
Schistosoma mansoni alpha-1 adrenergic receptor 0.0563 0.4099 0.4099
Echinococcus multilocularis sex peptide receptor 0.0563 0.4099 0.5615
Loa Loa (eye worm) G-protein coupled receptor 0.0563 0.4099 0.5246
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0563 0.4099 0.5246
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0563 0.4099 0.4099
Onchocerca volvulus 0.0203 0.1277 0.1635
Echinococcus granulosus enteropeptidase 0.0145 0.0828 0.1134
Schistosoma mansoni amine GPCR 0.0563 0.4099 0.4099
Onchocerca volvulus 0.0563 0.4099 0.5246
Echinococcus granulosus glycine receptor subunit alpha 1 0.0065 0.0197 0.027
Loa Loa (eye worm) hypothetical protein 0.0563 0.4099 0.5246
Onchocerca volvulus 0.0563 0.4099 0.5246
Schistosoma mansoni biogenic amine receptor 0.0563 0.4099 0.4099
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0145 0.0828 0.1059
Brugia malayi ORL1-like opioid receptor 0.0563 0.4099 0.5246
Echinococcus granulosus tm gpcr rhodopsin 0.0563 0.4099 0.5615
Echinococcus granulosus g protein coupled receptor 0.0563 0.4099 0.5615
Brugia malayi Tachykinin-like peptides receptor 99D 0.0563 0.4099 0.5246
Loa Loa (eye worm) hypothetical protein 0.0145 0.0828 0.1059
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0563 0.4099 0.4099
Brugia malayi excitatory GABA receptor EXP-1A 0.0065 0.0197 0.0252
Echinococcus granulosus glycine receptor subunit beta 0.0065 0.0197 0.027
Loa Loa (eye worm) hypothetical protein 0.0563 0.4099 0.5246
Schistosoma mansoni cercarial elastase (S01 family) 0.0145 0.0828 0.0828
Echinococcus multilocularis neuropeptides capa receptor 0.0563 0.4099 0.5615
Brugia malayi Trypsin-like protease protein 5 0.0145 0.0828 0.1059
Loa Loa (eye worm) hypothetical protein 0.0131 0.0718 0.0919
Loa Loa (eye worm) hypothetical protein 0.0563 0.4099 0.5246
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0145 0.0828 0.0828
Echinococcus granulosus rhodopsin orphan GPCR 0.0563 0.4099 0.5615
Loa Loa (eye worm) neuropeptide F receptor 0.0563 0.4099 0.5246
Loa Loa (eye worm) hypothetical protein 0.0563 0.4099 0.5246
Echinococcus granulosus rhodopsin orphan GPCR 0.0563 0.4099 0.5615
Schistosoma mansoni myosin xvIII 0.0563 0.4099 0.4099
Loa Loa (eye worm) hypothetical protein 0.0065 0.0197 0.0252
Echinococcus granulosus biogenic amine 5HT receptor 0.0563 0.4099 0.5615
Onchocerca volvulus 0.0113 0.0575 0.0736
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0563 0.4099 0.4099
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0065 0.0197 0.0252
Loa Loa (eye worm) hypothetical protein 0.0563 0.4099 0.5246
Schistosoma mansoni cercarial elastase (S01 family) 0.0145 0.0828 0.0828
Onchocerca volvulus 0.0065 0.0197 0.0252
Echinococcus granulosus glycine receptor subunit alpha 1 0.0065 0.0197 0.027
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0065 0.0197 0.027
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0065 0.0197 0.027
Brugia malayi solute carrier family 40, member 1 0.0219 0.1404 0.1797
Echinococcus multilocularis rhodopsin orphan GPCR 0.0563 0.4099 0.5615
Onchocerca volvulus 0.0145 0.0828 0.1059
Onchocerca volvulus 0.0563 0.4099 0.5246
Brugia malayi Serotonin receptor 0.0563 0.4099 0.5246
Schistosoma mansoni growth hormone secretagogue receptor 0.0563 0.4099 0.4099
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0563 0.4099 0.5246
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0065 0.0197 0.0252
Loa Loa (eye worm) hypothetical protein 0.0145 0.0828 0.1059
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0563 0.4099 0.4099
Loa Loa (eye worm) calcium channel 0.0095 0.0439 0.0562
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0065 0.0197 0.027
Onchocerca volvulus 0.0113 0.0575 0.0736
Loa Loa (eye worm) hypothetical protein 0.0563 0.4099 0.5246
Schistosoma mansoni cercarial elastase (S01 family) 0.0145 0.0828 0.0828
Loa Loa (eye worm) PAN domain-containing protein 0.0113 0.0575 0.0736
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0095 0.0439 0.0601
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0563 0.4099 0.4099
Echinococcus granulosus neuropeptides capa receptor 0.0563 0.4099 0.5615
Loa Loa (eye worm) hypothetical protein 0.0065 0.0197 0.0252
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0065 0.0197 0.027
Loa Loa (eye worm) hypothetical protein 0.0065 0.0197 0.0252
Brugia malayi PAN domain containing protein 0.0113 0.0575 0.0736
Loa Loa (eye worm) hypothetical protein 0.0065 0.0197 0.0252
Loa Loa (eye worm) hypothetical protein 0.1038 0.7812 1
Onchocerca volvulus 0.0113 0.0575 0.0736
Echinococcus multilocularis g-protein coupled receptor 0.0563 0.4099 0.5615
Loa Loa (eye worm) hypothetical protein 0.0065 0.0197 0.0252
Echinococcus granulosus neuropeptides capa receptor 0.0973 0.7299 1
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0223 0.1438 0.5
Echinococcus granulosus dro:myosuppressin receptor 0.0563 0.4099 0.5615
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0065 0.0197 0.027
Echinococcus multilocularis dro:myosuppressin receptor 0.0563 0.4099 0.5615
Schistosoma mansoni neuropeptide F-like receptor 0.0563 0.4099 0.4099
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0065 0.0197 0.0252
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0563 0.4099 0.4099
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0065 0.0197 0.0252
Entamoeba histolytica hypothetical protein 0.0041 0.001 1
Loa Loa (eye worm) hypothetical protein 0.0145 0.0828 0.1059
Loa Loa (eye worm) TK/ROR protein kinase 0.0223 0.1438 0.184
Brugia malayi hypothetical protein 0.0563 0.4099 0.5246
Schistosoma mansoni neuropeptide F-like receptor 0.0563 0.4099 0.4099
Onchocerca volvulus Neuropeptide F receptor homolog 0.0563 0.4099 0.5246
Echinococcus multilocularis neuropeptide receptor A26 0.0563 0.4099 0.5615
Echinococcus granulosus rhodopsin orphan GPCR 0.0563 0.4099 0.5615
Onchocerca volvulus 0.0145 0.0828 0.1059
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0065 0.0197 0.0197
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.001 0.0014
Echinococcus multilocularis voltage dependent calcium channel 0.0095 0.0439 0.0601
Brugia malayi Serotonin receptor 0.0563 0.4099 0.5246
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0065 0.0197 0.027
Onchocerca volvulus 0.0563 0.4099 0.5246
Echinococcus multilocularis rhodopsin orphan GPCR 0.0563 0.4099 0.5615
Loa Loa (eye worm) hypothetical protein 0.0563 0.4099 0.5246
Schistosoma mansoni amine GPCR 0.0563 0.4099 0.4099
Echinococcus multilocularis tissue type plasminogen activator 0.0223 0.1438 0.197
Loa Loa (eye worm) hypothetical protein 0.0563 0.4099 0.5246
Onchocerca volvulus 0.0563 0.4099 0.5246
Onchocerca volvulus 0.0203 0.1277 0.1635
Brugia malayi SEA domain containing protein 0.0131 0.0718 0.0919
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0065 0.0197 0.0252
Loa Loa (eye worm) hypothetical protein 0.0563 0.4099 0.5246
Echinococcus multilocularis orexin receptor type 2 0.0563 0.4099 0.5615
Onchocerca volvulus 0.1038 0.7812 1
Echinococcus granulosus g protein coupled receptor 0.0563 0.4099 0.5615
Brugia malayi G protein-coupled receptor 0.0563 0.4099 0.5246
Onchocerca volvulus 0.0563 0.4099 0.5246
Echinococcus granulosus orexin receptor type 2 0.0563 0.4099 0.5615
Schistosoma mansoni amine GPCR 0.0563 0.4099 0.4099
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0563 0.4099 0.4099
Echinococcus granulosus neuropeptide FF receptor 2 0.0563 0.4099 0.5615
Echinococcus granulosus neuropeptide receptor A26 0.0563 0.4099 0.5615
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0563 0.4099 0.5615
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0563 0.4099 0.5615
Entamoeba histolytica hypothetical protein 0.0041 0.001 1
Onchocerca volvulus Putative nachr subunit 0.0065 0.0197 0.0252
Schistosoma mansoni hypothetical protein 0.0223 0.1438 0.1438
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0065 0.0197 0.0252
Echinococcus granulosus glycine receptor subunit alpha 1 0.0065 0.0197 0.027
Schistosoma mansoni nAChR subunit 0.0065 0.0197 0.0197
Brugia malayi PAN domain containing protein 0.0113 0.0575 0.0736
Loa Loa (eye worm) hypothetical protein 0.0113 0.0575 0.0736
Echinococcus granulosus Mastin 0.0145 0.0828 0.1134
Loa Loa (eye worm) neuropeptide F receptor 0.0563 0.4099 0.5246
Loa Loa (eye worm) hypothetical protein 0.0563 0.4099 0.5246
Echinococcus multilocularis rhodopsin orphan GPCR 0.0563 0.4099 0.5615
Loa Loa (eye worm) hypothetical protein 0.0065 0.0197 0.0252
Loa Loa (eye worm) hypothetical protein 0.0145 0.0828 0.1059
Plasmodium falciparum cysteine repeat modular protein 1 0.0223 0.1438 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0563 0.4099 0.5615
Onchocerca volvulus 0.0563 0.4099 0.5246
Echinococcus granulosus neuropeptide Y receptor 0.0563 0.4099 0.5615
Echinococcus multilocularis fmrfamide receptor 0.0563 0.4099 0.5615
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0563 0.4099 0.5615
Leishmania major hypothetical protein, conserved 0.0223 0.1438 0.5
Onchocerca volvulus 0.0563 0.4099 0.5246
Loa Loa (eye worm) hypothetical protein 0.0563 0.4099 0.5246
Echinococcus granulosus sex peptide receptor 0.0563 0.4099 0.5615
Brugia malayi sulfakinin receptor protein 0.0563 0.4099 0.5246
Loa Loa (eye worm) hypothetical protein 0.0563 0.4099 0.5246
Onchocerca volvulus 0.0563 0.4099 0.5246
Brugia malayi Cation transporter family protein 0.0065 0.0197 0.0252
Brugia malayi Kringle domain containing protein 0.0223 0.1438 0.184
Schistosoma mansoni neuropeptide receptor 0.0563 0.4099 0.4099
Echinococcus granulosus hypothetical protein 0.0563 0.4099 0.5615
Schistosoma mansoni amine GPCR 0.0563 0.4099 0.4099
Echinococcus granulosus allatostatin A receptor 0.0563 0.4099 0.5615
Echinococcus multilocularis somatostatin receptor 0.0563 0.4099 0.5615
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0563 0.4099 0.4099
Schistosoma mansoni hypothetical protein 0.0563 0.4099 0.4099
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0111 0.0143
Echinococcus multilocularis sodium channel protein 0.0041 0.0009 0.0012
Echinococcus multilocularis neuropeptide receptor 0.0563 0.4099 0.5615
Echinococcus granulosus G protein coupled receptor 139 0.0563 0.4099 0.5615
Loa Loa (eye worm) G-protein coupled receptor 0.0563 0.4099 0.5246
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0058 0.0147 0.5
Loa Loa (eye worm) ACC-1 protein 0.0065 0.0197 0.0252
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0065 0.0197 0.027
Loa Loa (eye worm) hypothetical protein 0.0095 0.0439 0.0562
Brugia malayi PAN domain containing protein 0.0113 0.0575 0.0736
Echinococcus granulosus 7TM GPCR rhodopsin 0.0563 0.4099 0.5615
Echinococcus granulosus rhodopsin orphan GPCR 0.0563 0.4099 0.5615
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0563 0.4099 0.4099
Echinococcus granulosus fmrfamide receptor 0.0563 0.4099 0.5615
Schistosoma mansoni hypothetical protein 0.0563 0.4099 0.4099
Brugia malayi Muscle positioning protein 4 0.0131 0.0718 0.0919
Loa Loa (eye worm) hypothetical protein 0.0065 0.0197 0.0252
Onchocerca volvulus 0.0223 0.1438 0.184
Onchocerca volvulus 0.0065 0.0197 0.0252
Schistosoma mansoni hypothetical protein 0.0563 0.4099 0.4099
Onchocerca volvulus 0.0145 0.0828 0.1059
Onchocerca volvulus 0.0563 0.4099 0.5246
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.1082 0.815 0.815
Echinococcus granulosus neuropeptide receptor 0.0563 0.4099 0.5615
Onchocerca volvulus 0.0113 0.0575 0.0736
Echinococcus multilocularis glycoprotein Antigen 5 0.0145 0.0828 0.1134

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) > 16 ug ml-1 Antifungal activity against azole-resistant Candida albicans clinical isolate 7.O.A assessed as growth inhibition after 24 to 48 hrs by CLSI microbroth dilution method ChEMBL. 23403080

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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