GI50 (functional)
|
-8
|
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
GI50 (functional)
|
-7.918
|
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
GI50 (functional)
|
-7.73
|
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
GI50 (functional)
|
-7.566
|
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
GI50 (functional)
|
-7.558
|
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
GI50 (functional)
|
-7.461
|
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
GI50 (functional)
|
-7.365
|
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
GI50 (functional)
|
-6.901
|
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
GI50 (functional)
|
-6.899
|
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
GI50 (functional)
|
-6.812
|
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
GI50 (functional)
|
-6.809
|
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
Growth (functional)
|
= -96 %
|
Percent growth of CNS SNB-19 cell line at compound concentration 10e-5 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -96 %
|
Percent growth of CNS SNB-19 cell line at compound concentration 10e-5 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -95 %
|
Percent growth of lung-NSC NCI-H460 cell line at compound concentration 10e-5 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -95 %
|
Percent growth of renal 786-0 cell line at compound concentration 10e-5 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -95 %
|
Percent growth of lung-NSC NCI-H460 cell line at compound concentration 10e-5 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -95 %
|
Percent growth of renal 786-0 cell line at compound concentration 10e-5 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -94 %
|
Percent growth of colon HCT-116 cell line at compound concentration 10e-5 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -94 %
|
Percent growth of colon HCT-116 cell line at compound concentration 10e-5 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -93 %
|
Percent growth of melanoma LOX IMVI cell line at compound concentration 10e-5 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -93 %
|
Percent growth of prostate DU-145 cell line at compound concentration 10e-5 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -93 %
|
Percent growth of melanoma LOX IMVI cell line at compound concentration 10e-5 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -93 %
|
Percent growth of prostate DU-145 cell line at compound concentration 10e-5 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -86 %
|
Percent growth of breast MCF-7 cell line at compound concentration 10e-5 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -86 %
|
Percent growth of breast MCF-7 cell line at compound concentration 10e-5 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -72 %
|
Percent growth of ovarian OVCAR-4 cell line at compound concentration 10e-5 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -72 %
|
Percent growth of ovarian OVCAR-4 cell line at compound concentration 10e-5 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -58 %
|
Percent growth of leukemia RPMI-8226 cell line at compound concentration 10e-5 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -58 %
|
Percent growth of leukemia RPMI-8226 cell line at compound concentration 10e-5 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -44 %
|
Percent growth of leukemia RPMI-8226 cell line at compound concentration 10e-6 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -44 %
|
Percent growth of leukemia RPMI-8226 cell line at compound concentration 10e-6 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -40 %
|
Percent growth of melanoma LOX IMVI cell line at compound concentration 10e-6 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -40 %
|
Percent growth of melanoma LOX IMVI cell line at compound concentration 10e-6 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -31 %
|
Percent growth of lung-NSC NCI-H460 cell line at compound concentration 10e-6 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -31 %
|
Percent growth of lung-NSC NCI-H460 cell line at compound concentration 10e-6 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -7 %
|
Percent growth of CNS SNB-19 cell line at compound concentration 10e-6 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -7 %
|
Percent growth of CNS SNB-19 cell line at compound concentration 10e-6 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -5 %
|
Percent growth of colon HCT-116 cell line at compound concentration 10e-6 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -5 %
|
Percent growth of colon HCT-116 cell line at compound concentration 10e-6 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -2 %
|
Percent growth of prostate DU-145 cell line at compound concentration 10e-6 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= -2 %
|
Percent growth of prostate DU-145 cell line at compound concentration 10e-6 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= 0 %
|
Percent growth of breast MCF-7 cell line at compound concentration 10e-6 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= 0 %
|
Percent growth of breast MCF-7 cell line at compound concentration 10e-6 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= 6 %
|
Percent growth of renal 786-0 cell line at compound concentration 10e-6 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= 6 %
|
Percent growth of renal 786-0 cell line at compound concentration 10e-6 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= 12 %
|
Percent growth of leukemia RPMI-8226 cell line at compound concentration 10e-8 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= 12 %
|
Percent growth of leukemia RPMI-8226 cell line at compound concentration 10e-8 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= 16 %
|
Percent growth of ovarian OVCAR-4 cell line at compound concentration 10e-6 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= 16 %
|
Percent growth of ovarian OVCAR-4 cell line at compound concentration 10e-6 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= 26 %
|
Percent growth of breast MCF-7 cell line at compound concentration 10e-8 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= 26 %
|
Percent growth of breast MCF-7 cell line at compound concentration 10e-8 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= 28 %
|
Percent growth of lung-NSC NCI-H460 cell line at compound concentration 10e-8 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= 28 %
|
Percent growth of melanoma LOX IMVI cell line at compound concentration 10e-8 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= 28 %
|
Percent growth of lung-NSC NCI-H460 cell line at compound concentration 10e-8 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= 28 %
|
Percent growth of melanoma LOX IMVI cell line at compound concentration 10e-8 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= 31 %
|
Percent growth of colon HCT-116 cell line at compound concentration 10e-8 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= 31 %
|
Percent growth of colon HCT-116 cell line at compound concentration 10e-8 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= 41 %
|
Percent growth of renal 786-0 cell line at compound concentration 10e-8 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= 41 %
|
Percent growth of renal 786-0 cell line at compound concentration 10e-8 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= 42 %
|
Percent growth of CNS SNB-19 cell line at compound concentration 10e-8 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= 42 %
|
Percent growth of CNS SNB-19 cell line at compound concentration 10e-8 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= 55 %
|
Percent growth of prostate DU-145 cell line at compound concentration 10e-8 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= 55 %
|
Percent growth of prostate DU-145 cell line at compound concentration 10e-8 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= 67 %
|
Percent growth of ovarian OVCAR-4 cell line at compound concentration 10e-8 was determined
|
ChEMBL.
|
12825949
|
Growth (functional)
|
= 67 %
|
Percent growth of ovarian OVCAR-4 cell line at compound concentration 10e-8 was determined
|
ChEMBL.
|
12825949
|
IC50 (functional)
|
< 0.1 nM
|
Cytotoxicity of the compound is determined as the concentration required to inhibit the growth of human colon adenocarcinoma (HT-29) cell line
|
ChEMBL.
|
15456268
|
IC50 (functional)
|
< 0.1 nM
|
Cytotoxicity of the compound is determined as the concentration required to inhibit the growth of human colon adenocarcinoma (HT-29) cell line
|
ChEMBL.
|
15456268
|
IC50 (functional)
|
< 0.0001 uM
|
In vitro cytotoxic activity against human colon adenocarcinoma (HT-29).
|
ChEMBL.
|
12825949
|
IC50 (functional)
|
< 0.0001 uM
|
In vitro cytotoxic activity against human colon adenocarcinoma (HT-29).
|
ChEMBL.
|
12825949
|
K app (binding)
|
= 14 10e-7/M
|
Concentration required to displace ethidium from CT-DNA was determined from fluorescence binding studies
|
ChEMBL.
|
15456268
|
K app (binding)
|
= 19 10e-7/M
|
Concentration required to displace ethidium from [poly(dA-dT)]2 (AT) was determined from fluorescence binding studies
|
ChEMBL.
|
15456268
|
K app (binding)
|
= 23 10e-7/M
|
Concentration required to displace ethidium from [poly(dG-dC)]2 (GC) was determined from fluorescence binding studies
|
ChEMBL.
|
15456268
|
K app (ADMET)
|
= 14 M-1
|
Apparent equilibrium constant for DNA binding (C-T)
|
ChEMBL.
|
12825949
|
K app (ADMET)
|
= 19 M-1
|
Apparent equilibrium constant for DNA binding (A-T)
|
ChEMBL.
|
12825949
|
K app (ADMET)
|
= 23 M-1
|
Apparent equilibrium constant for DNA binding (G-C)
|
ChEMBL.
|
12825949
|