Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | glucose transport protein | 0.0104 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0104 | 1 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0032 | 0 | 0.5 |
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0032 | 0 | 0.5 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0104 | 1 | 1 |
Leishmania major | glucose transporter, lmgt2 | 0.0032 | 0 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0032 | 0 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0032 | 0 | 0.5 |
Toxoplasma gondii | facilitative glucose transporter GT1 | 0.0104 | 1 | 0.5 |
Leishmania major | glucose transporter, lmgt3 | 0.0032 | 0 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0032 | 0 | 0.5 |
Plasmodium vivax | hexose transporter | 0.0104 | 1 | 0.5 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0104 | 1 | 1 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0104 | 1 | 1 |
Trypanosoma brucei | glucose transporter 1E | 0.0032 | 0 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0032 | 0 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0032 | 0 | 0.5 |
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0032 | 0 | 0.5 |
Schistosoma mansoni | glucose transport protein | 0.0104 | 1 | 0.5 |
Schistosoma mansoni | glucose transport protein | 0.0104 | 1 | 0.5 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0104 | 1 | 1 |
Leishmania major | glucose transporter, lmgt1 | 0.0032 | 0 | 0.5 |
Loa Loa (eye worm) | sugar transporter | 0.0104 | 1 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0032 | 0 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0032 | 0 | 0.5 |
Trypanosoma brucei | glucose transporter 2A | 0.0032 | 0 | 0.5 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0104 | 1 | 1 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0104 | 1 | 1 |
Trypanosoma cruzi | hexose transporter | 0.0032 | 0 | 0.5 |
Trypanosoma cruzi | hexose transporter, putative | 0.0032 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0104 | 1 | 1 |
Trypanosoma cruzi | hexose transporter, putative | 0.0032 | 0 | 0.5 |
Echinococcus multilocularis | solute carrier family 2, facilitated glucose | 0.0104 | 1 | 1 |
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0032 | 0 | 0.5 |
Trypanosoma cruzi | hexose transporter, putative | 0.0032 | 0 | 0.5 |
Leishmania major | glucose transporter/membrane transporter D2, putative | 0.0032 | 0 | 0.5 |
Plasmodium falciparum | hexose transporter | 0.0104 | 1 | 0.5 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0104 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | = 97 % | Antitubercular activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition after 12 to 28 days by L.J. agar MIC method | ChEMBL. | 23434641 |
MIC (functional) | = 62.5 ug ml-1 | Antimicrobial activity against Escherichia coli MTCC 443 assessed as growth inhibition measured after overnight incubation by broth dilution method | ChEMBL. | 23434641 |
MIC (functional) | = 500 ug ml-1 | Antimicrobial activity against Candida albicans MTCC 227 assessed as growth inhibition measured after overnight incubation by broth dilution method | ChEMBL. | 23434641 |
MIC (functional) | = 500 ug ml-1 | Antitubercular activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition after 12 to 28 days by L.J. agar MIC method | ChEMBL. | 23434641 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.