Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | Biotin--acetyl-CoA-carboxylase ligase, putative | 0.1342 | 0 | 0.5 |
Brugia malayi | biotin--acetyl-CoA-carboxylase ligase family protein | 0.1342 | 0 | 0.5 |
Loa Loa (eye worm) | biotin protein ligase 1 | 0.1342 | 0 | 0.5 |
Plasmodium falciparum | biotin protein ligase, putative | 0.1342 | 0 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.1342 | 0 | 0.5 |
Plasmodium falciparum | biotin--acetyl-CoA-carboxylase, putative | 0.1342 | 0 | 0.5 |
Treponema pallidum | biotin--acetyl-CoA-carboxylase ligase | 0.2864 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | biotin-(acetyl-CoA carboxylase) ligase | 0.1342 | 0 | 0.5 |
Mycobacterium ulcerans | bifunctional protein BirA | 0.2739 | 0.9183 | 0.5 |
Entamoeba histolytica | biotin--acetyl-CoA-carboxylase ligase, putative | 0.1342 | 0 | 0.5 |
Chlamydia trachomatis | biotin synthetase | 0.1342 | 0 | 0.5 |
Echinococcus multilocularis | biotin protein ligase | 0.1342 | 0 | 0.5 |
Trypanosoma brucei | Biotin--acetyl-CoA-carboxylase ligase, putative | 0.1342 | 0 | 0.5 |
Echinococcus multilocularis | biotin protein ligase | 0.1342 | 0 | 0.5 |
Leishmania major | biotin/lipoate protein ligase-like protein | 0.1342 | 0 | 0.5 |
Schistosoma mansoni | biotin-protein ligase | 0.1342 | 0 | 0.5 |
Trypanosoma cruzi | Biotin--acetyl-CoA-carboxylase ligase, putative | 0.1342 | 0 | 0.5 |
Plasmodium vivax | biotin--[acetyl-CoA-carboxylase] synthetase, putative | 0.1342 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 100 uM | Inhibition of recombinant CDK2/cyclin E (unknown origin) using histone H1 as substrate in presence of [gamma-33P]ATP | ChEMBL. | 23399722 |
IC50 (binding) | > 100 uM | Inhibition of recombinant CDK1/cyclin B (unknown origin) using histone H1 as substrate in presence of [gamma-33P]ATP | ChEMBL. | 23399722 |
IC50 (functional) | > 100 uM | Cytotoxicity against human MCF7 cells assessed as inhibition of cell viability after 72 hrs by calcien AM dye based fluorescence analysis | ChEMBL. | 23399722 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.