Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | D-amino-acid oxidase | Starlite/ChEMBL | References |
Homo sapiens | D-amino-acid oxidase | Starlite/ChEMBL | References |
Mus musculus | D-amino acid oxidase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Unconventional prefoldin RPB5 interactor 1 homolog | D-amino-acid oxidase | 346 aa | 350 aa | 31.1 % |
Mycobacterium ulcerans | D-amino acid oxidase Aao | D-amino-acid oxidase | 346 aa | 382 aa | 24.1 % |
Mycobacterium ulcerans | D-amino acid oxidase Aao | D-amino-acid oxidase | 347 aa | 378 aa | 24.6 % |
Candida albicans | similar to putative d-amino acid oxidase | D-amino-acid oxidase | 346 aa | 388 aa | 22.2 % |
Mycobacterium ulcerans | D-amino acid oxidase Aao | D-amino acid oxidase | 345 aa | 381 aa | 23.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | d-amino acid oxidase | 0.0584 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable D-amino acid oxidase Aao | 0.0536 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE D-AMINO ACID OXIDASE AAO | 0.0584 | 1 | 0.5 |
Mycobacterium ulcerans | D-amino acid oxidase Aao | 0.0584 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CL (ADMET) | = 38.7 ml/min.kg | Clearance in CD1 mouse at 10 mg/kg, iv | ChEMBL. | 26309148 |
Cp (ADMET) | = 6540 ng/ml | Plasma concentration in ddY mouse at 30 mg/kg, po after 30 mins by LC-MS/MS analysis | ChEMBL. | 23566269 |
F (ADMET) | = 31 % | Oral bioavailability in CD1 mouse at 30 mg/kg | ChEMBL. | 25408840 |
IC50 (binding) | = 1.5 nM | Inhibition of human recombinant DAAO after 30 mins by plate reader analysis | ChEMBL. | 23566269 |
IC50 (binding) | = 1.5 nM | Inhibition Assay | BINDINGDB. | No reference |
IC50 (binding) | = 4.4 nM | Inhibition of mouse full length DAAO overexpressed in HEK293 cells after 30 mins by plate reader analysis | ChEMBL. | 23566269 |
IC50 (binding) | = 7 nM | Inhibition of human full length DAAO overexpressed in HEK293 cells after 30 mins by plate reader analysis | ChEMBL. | 23566269 |
IC50 (binding) | = 7 nM | Inhibition Assay | BINDINGDB. | No reference |
IC50 (binding) | = 11 nM | In Vitro DAAO Enzyme Assay | BINDINGDB. | No reference |
IC50 (binding) | = 16 nM | Inhibition of rat full length DAAO overexpressed in HEK293 cells after 30 mins by plate reader analysis | ChEMBL. | 23566269 |
Stabilty (ADMET) | = 81 % | Drug metabolism in human liver microsomes assessed as glucuronidation of compound measured as compound remaining after 30 mins by LC/MS analysis | ChEMBL. | 25408840 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.