Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase kinase kinase 14 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | 3 oxoacyl acyl carrier protein reductase | 0.0105 | 0 | 0.5 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0105 | 0 | 0.5 |
Onchocerca volvulus | 0.0105 | 0 | 0.5 | |
Schistosoma mansoni | 3-oxoacyl-[ACP] reductase | 0.0105 | 0 | 0.5 |
Leishmania major | 3-oxoacyl-ACP reductase, putative | 0.0105 | 0 | 0.5 |
Trypanosoma brucei | pteridine reductase 1 | 0.0105 | 0 | 0.5 |
Echinococcus multilocularis | 3 oxoacyl acyl carrier protein reductase | 0.0105 | 0 | 0.5 |
Onchocerca volvulus | 0.0105 | 0 | 0.5 | |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0105 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.1557 | 1 | 1 |
Loa Loa (eye worm) | retinol dehydrogenase 12 | 0.0105 | 0 | 0.5 |
Trypanosoma brucei | beta-ketoacyl-ACP reductase | 0.0105 | 0 | 0.5 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0105 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0 | 0.5 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0105 | 0 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0105 | 0 | 0.5 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0105 | 0 | 0.5 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.1557 | 1 | 1 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.1557 | 1 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.1557 | 1 | 1 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.1557 | 1 | 1 |
Leishmania major | pteridine reductase 1 | 0.0105 | 0 | 0.5 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.1557 | 1 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.1557 | 1 | 0.5 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0105 | 0 | 0.5 |
Leishmania major | oxidoreductase-like protein | 0.0105 | 0 | 0.5 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0105 | 0 | 0.5 |
Trypanosoma brucei | oxidoreductase-like protein | 0.0105 | 0 | 0.5 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.1557 | 1 | 1 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0105 | 0 | 0.5 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0105 | 0 | 0.5 |
Schistosoma mansoni | dihydropteridine reductase | 0.0105 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.31 uM | Inhibition of NIK (unknown origin) autophosphorylation after 1 hr by chemiluminescent assay | ChEMBL. | 23374866 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.