Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Kinase, AGC PKA | 0.0776 | 0.2611 | 0.5 |
Echinococcus multilocularis | cAMP dependent protein kinase catalytic subunit | 0.0776 | 0.2611 | 0.4236 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0776 | 0.2611 | 0.4236 |
Trypanosoma cruzi | cAMP-dependent protein kinase catalytic subunit 2 | 0.0776 | 0.2611 | 0.5 |
Schistosoma mansoni | protein kinase | 0.18 | 0.6165 | 1 |
Trypanosoma cruzi | cAMP-dependent protein kinase catalytic subunit 1 | 0.0776 | 0.2611 | 0.5 |
Leishmania major | protein kinase A catalytic subunit isoform 2 | 0.0776 | 0.2611 | 0.5 |
Echinococcus multilocularis | PKC activated phosphatase 1 inhibitor | 0.0183 | 0.0551 | 0.0893 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0942 | 0.3186 | 0.5167 |
Echinococcus granulosus | dual specificity testis-specific protein kinase | 0.18 | 0.6165 | 1 |
Echinococcus multilocularis | enhancer of mRNA decapping protein 4 | 0.0764 | 0.257 | 0.4168 |
Leishmania major | protein kinase A catalytic subunit isoform 1 | 0.0776 | 0.2611 | 0.5 |
Echinococcus granulosus | rho-associated protein kinase 1 | 0.0942 | 0.3186 | 0.5167 |
Echinococcus granulosus | peripheral plasma membrane protein CASK | 0.0035 | 0.0038 | 0.0062 |
Loa Loa (eye worm) | hypothetical protein | 0.0776 | 0.2611 | 0.2583 |
Loa Loa (eye worm) | AGC/DMPK/ROCK protein kinase | 0.2904 | 1 | 1 |
Trypanosoma brucei | cAMP-dependent protein kinase catalytic subunit 2 | 0.0776 | 0.2611 | 0.5 |
Echinococcus multilocularis | cAMP dependent protein kinase catalytic subunit | 0.0776 | 0.2611 | 0.4236 |
Echinococcus granulosus | Microtubule-associated serine/threonine-protein kinase | 0.0035 | 0.0038 | 0.0062 |
Plasmodium vivax | cAMP-dependent protein kinase catalytic subunit, putative | 0.0776 | 0.2611 | 0.5 |
Trypanosoma brucei | protein kinase A catalytic subunit, putative | 0.0776 | 0.2611 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0776 | 0.2611 | 0.4236 |
Toxoplasma gondii | AGC kinase | 0.0776 | 0.2611 | 0.5 |
Echinococcus multilocularis | cAMP dependent protein kinase catalytic subunit | 0.0776 | 0.2611 | 0.4236 |
Onchocerca volvulus | 0.0942 | 0.3186 | 1 | |
Trypanosoma cruzi | cAMP-dependent protein kinase catalytic subunit 3 | 0.0776 | 0.2611 | 0.5 |
Trypanosoma brucei | cAMP-dependent protein kinase catalytic subunit 1 | 0.0776 | 0.2611 | 0.5 |
Onchocerca volvulus | 0.0183 | 0.0551 | 0.1628 | |
Plasmodium falciparum | cAMP-dependent protein kinase catalytic subunit | 0.0776 | 0.2611 | 0.5 |
Trypanosoma cruzi | cAMP-dependent protein kinase catalytic subunit 3 | 0.0776 | 0.2611 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0551 | 0.0514 |
Echinococcus granulosus | cAMP dependent protein kinase catalytic subunit | 0.0776 | 0.2611 | 0.4236 |
Loa Loa (eye worm) | AGC/PKA protein kinase | 0.0776 | 0.2611 | 0.2583 |
Echinococcus granulosus | cAMP dependent protein kinase catalytic subunit | 0.0776 | 0.2611 | 0.4236 |
Brugia malayi | cAMP-dependent protein kinase catalytic subunit, putative | 0.0776 | 0.2611 | 0.2181 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0776 | 0.2611 | 0.5 |
Echinococcus multilocularis | peripheral plasma membrane protein CASK | 0.0035 | 0.0038 | 0.0062 |
Echinococcus granulosus | cAMP dependent protein kinase catalytic subunit | 0.0776 | 0.2611 | 0.4236 |
Loa Loa (eye worm) | AGC/PKA protein kinase | 0.0776 | 0.2611 | 0.2583 |
Echinococcus granulosus | PKC activated phosphatase 1 inhibitor | 0.0183 | 0.0551 | 0.0893 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0776 | 0.2611 | 0.4236 |
Leishmania major | protein kinase A catalytic subunit | 0.0776 | 0.2611 | 0.5 |
Echinococcus multilocularis | dual specificity testis specific protein kinase | 0.18 | 0.6165 | 1 |
Schistosoma mansoni | protein phosphatase 1 inhibitor potentiated by protein kinase C | 0.0183 | 0.0551 | 0.0893 |
Toxoplasma gondii | AGC kinase | 0.0776 | 0.2611 | 0.5 |
Schistosoma mansoni | protein kinase | 0.18 | 0.6165 | 1 |
Echinococcus multilocularis | cAMP dependent protein kinase catalytic subunit | 0.0776 | 0.2611 | 0.4236 |
Trichomonas vaginalis | AGC family protein kinase | 0.0776 | 0.2611 | 0.5 |
Echinococcus multilocularis | microtubule associated serine:threonine protein | 0.0035 | 0.0038 | 0.0062 |
Echinococcus granulosus | enhancer of mRNA decapping protein 4 | 0.0764 | 0.257 | 0.4168 |
Echinococcus multilocularis | rho associated protein kinase | 0.0942 | 0.3186 | 0.5167 |
Schistosoma mansoni | MAGUK homolog | 0.0035 | 0.0038 | 0.0062 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0776 | 0.2611 | 0.5 |
Toxoplasma gondii | protein kinase, cAMP-dependent, catalytic chain | 0.0776 | 0.2611 | 0.5 |
Onchocerca volvulus | 0.093 | 0.3144 | 0.9868 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 40.6 % | Inhibition of ovine COX2 assessed as appearance of oxidized N,N,N,N'- tetramethyl-p-phenylenediamine at 100 uM | ChEMBL. | 23357629 |
Inhibition (binding) | = 52.76 % | Inhibition of ovine COX1 assessed as appearance of oxidized N,N,N,N'- tetramethyl-p-phenylenediamine at 100 uM | ChEMBL. | 23357629 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.