Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glucosylceramidase, putative | 0.0555 | 0.3604 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0555 | 0.3604 | 1 |
Echinococcus multilocularis | fucosidase, alpha L 1, tissue | 0.0894 | 1 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0555 | 0.3604 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0555 | 0.3604 | 1 |
Mycobacterium ulcerans | alpha-L-fucosidase | 0.0894 | 1 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0384 | 0.037 | 0.1027 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0555 | 0.3604 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0555 | 0.3604 | 1 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0364 | 0 | 0.5 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0555 | 0.3604 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0555 | 0.3604 | 1 |
Schistosoma mansoni | alpha-l-fucosidase | 0.0541 | 0.3328 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0384 | 0.037 | 0.1027 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | > 60 uM | Cytotoxicity to HIV-1 IIIB chronically infected Molt-4 cells assayed using tetrazolium based colorimetric assay | ChEMBL. | 10560726 |
IC50 (functional) | = 0.79 uM | Anti-HIV activity against HIV-1 IIIB chronically infected Molt-4 cells | ChEMBL. | 10560726 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.