Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | macrophage colony stimulating factor 1 receptor | 0.0568 | 0.4542 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.001 | 0.001 |
Echinococcus multilocularis | Immunoglobulin | 0.0032 | 0.001 | 0.0098 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0045 | 0.012 | 0.1145 |
Echinococcus granulosus | neuroglian | 0.0032 | 0.001 | 0.0023 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.001 | 0.001 |
Schistosoma mansoni | cell adhesion molecule | 0.0032 | 0.001 | 0.0088 |
Schistosoma mansoni | vesicular amine transporter | 0.0042 | 0.0096 | 0.0824 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0154 | 0.1046 | 1 |
Echinococcus granulosus | roundabout 2 | 0.0032 | 0.001 | 0.0023 |
Toxoplasma gondii | hypothetical protein | 0.1213 | 1 | 0.5 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0032 | 0.001 | 0.0088 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0045 | 0.012 | 0.1028 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.001 | 0.001 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0045 | 0.012 | 0.1028 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0032 | 0.001 | 0.0098 |
Echinococcus granulosus | Immunoglobulin | 0.0032 | 0.001 | 0.0023 |
Brugia malayi | hypothetical protein | 0.0032 | 0.001 | 0.0098 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0035 | 0.0035 | 0.0035 |
Echinococcus granulosus | defective proboscis extension response | 0.0032 | 0.001 | 0.0023 |
Loa Loa (eye worm) | hypothetical protein | 0.1213 | 1 | 1 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.1213 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0168 | 0.1166 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1213 | 1 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0154 | 0.1046 | 0.2303 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0154 | 0.1046 | 0.1046 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0045 | 0.012 | 0.1145 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0144 | 0.096 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.001 | 0.001 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.001 | 0.001 |
Echinococcus granulosus | twitchin | 0.0032 | 0.001 | 0.0023 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0045 | 0.012 | 0.0264 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0168 | 0.1166 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0035 | 0.0035 | 0.0331 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.001 | 0.001 |
Echinococcus granulosus | voltage gated potassium channel | 0.0045 | 0.012 | 0.0264 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0032 | 0.001 | 0.0098 |
Echinococcus multilocularis | neuroglian | 0.0032 | 0.001 | 0.0098 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.001 | 0.001 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.0874 | 0.0874 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0144 | 0.096 | 1 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0032 | 0.001 | 0.0098 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.001 | 0.001 |
Echinococcus multilocularis | Immunoglobulin | 0.0032 | 0.001 | 0.0098 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0032 | 0.001 | 0.0023 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0045 | 0.012 | 0.1145 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.001 | 0.001 |
Schistosoma mansoni | nephrin | 0.0032 | 0.001 | 0.0088 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0032 | 0.001 | 0.0088 |
Echinococcus multilocularis | roundabout 2 | 0.0032 | 0.001 | 0.0098 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0154 | 0.1046 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.012 | 0.012 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | = 71.31 uM | Cytotoxicity against mouse NIH/3T3 cells assessed as growth inhibition after 24 hrs by MTT assay | ChEMBL. | 23357309 |
Inhibition (binding) | Inhibition of TNFalpha (unknown origin)-induced NF-kappaB activation in mouse NIH/3T3 cells assessed as inhibition of NF-kappaB binding to DNA at 20 uM after 6 hrs by luciferase reporter gene assay | ChEMBL. | 23357309 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.