Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adrenoceptor beta 2, surface | Starlite/ChEMBL | References |
Homo sapiens | adrenoceptor beta 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | gamma glutamyltransferase 1 | 0.0243 | 1 | 0.5 |
Schistosoma mansoni | gamma-glutamyltransferase-like protein 3 (T03 family) | 0.0243 | 1 | 0.5 |
Echinococcus granulosus | gamma glutamyltranspeptidase 1 | 0.0243 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable gamma-glutamyltranspeptidase precursor GgtB (gamma-glutamyltransferase) (glutamyl transpeptidase) | 0.0163 | 0 | 0.5 |
Echinococcus multilocularis | 0.0243 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 1 | 0.5 |
Echinococcus multilocularis | gamma glutamyltransferase 1 | 0.0243 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 1 | 0.5 |
Loa Loa (eye worm) | gamma-glutamyl transpeptidase | 0.0243 | 1 | 0.5 |
Onchocerca volvulus | 0.0243 | 1 | 0.5 | |
Onchocerca volvulus | 0.0243 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Agonist activity at AVPR2 (unknown origin) assessed as stimulation of beta arrestin recruitment | ChEMBL. | 24454993 | |
Activity (functional) | Agonist activity at AVPR2 (unknown origin) assessed as stimulation of cAMP production | ChEMBL. | 24454993 | |
Inhibition (functional) | Antagonist activity at AVPR2 (unknown origin) assessed as inhibition of [Arg8]-Vasopressin induced beta arrestin recruitment at 10 uM | ChEMBL. | 24454993 | |
Inhibition (functional) | Antagonist activity at AVPR2 (unknown origin) assessed as inhibition of [Arg8]-Vasopressin induced cAMP production at 10 to 100 uM | ChEMBL. | 24454993 | |
Ka (binding) | = 1.16 10'6/M/s | Binding affinity to N-terminal FLAG-tagged C-terminal His-10-tagged human beta2 adrenoceptor expressed in insect Sf9 cells by surface plasmon resonance analysis | ChEMBL. | 24454993 |
Kd (binding) | = 72.5 nM | Binding affinity to N-terminal FLAG-tagged C-terminal His-10-tagged human beta2 adrenoceptor expressed in insect Sf9 cells by surface plasmon resonance analysis in presence of maltose neopentyl glycol | ChEMBL. | 24454993 |
Kd (binding) | = 93.4 nM | Binding affinity to N-terminal FLAG-tagged C-terminal His-10-tagged human beta2 adrenoceptor expressed in insect Sf9 cells by surface plasmon resonance analysis | ChEMBL. | 24454993 |
Ki (binding) | = 5.8 | Displacement of [3H]dihydroalprenolol from human wild type beta1 adrenergic receptor expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting analysis | ChEMBL. | 23517028 |
Kic (binding) | = 342.8 nM | Displacement of [125I]-Cyanopindolol from human beta2 adrenoceptor expressed in HEK293 cells after 90 mins by gamma counting analysis | ChEMBL. | 24454993 |
Kic (binding) | = 963.4 nM | Displacement of [125I]-Cyanopindolol from human beta1 adrenoceptor expressed in HEK293 cells after 90 mins by gamma counting analysis | ChEMBL. | 24454993 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.