Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0031 | 0.0123 | 0.0123 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0905 | 1 | 0.5 |
Loa Loa (eye worm) | lipase | 0.0905 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0905 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0905 | 1 | 1 |
Trypanosoma brucei | lipase domain protein, putative | 0.0905 | 1 | 1 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0905 | 1 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0905 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0031 | 0.0123 | 0.0123 |
Onchocerca volvulus | 0.0905 | 1 | 0.5 | |
Trichomonas vaginalis | lipase containing protein, putative | 0.0905 | 1 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.0905 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.002 | 0 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0905 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.