Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | chemokine (C-C motif) receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | biotin protein ligase, putative | 0.106 | 0.0755 | 0.5 |
Entamoeba histolytica | hypothetical protein, conserved | 0.1445 | 0.1702 | 1 |
Trypanosoma cruzi | Biotin--acetyl-CoA-carboxylase ligase, putative | 0.106 | 0.0755 | 0.5 |
Echinococcus multilocularis | N terminal of biotin protein ligase | 0.1445 | 0.1702 | 1 |
Plasmodium vivax | biotin--[acetyl-CoA-carboxylase] synthetase, putative | 0.106 | 0.0755 | 0.5 |
Brugia malayi | biotin--acetyl-CoA-carboxylase ligase family protein | 0.106 | 0.0755 | 0.5 |
Entamoeba histolytica | hypothetical protein, conserved | 0.1445 | 0.1702 | 1 |
Loa Loa (eye worm) | biotin protein ligase 1 | 0.106 | 0.0755 | 1 |
Entamoeba histolytica | hypothetical protein, conserved | 0.1445 | 0.1702 | 1 |
Leishmania major | biotin/lipoate protein ligase-like protein | 0.106 | 0.0755 | 0.5 |
Mycobacterium leprae | POSSIBLE BIFUNCTIONAL PROTEIN BirA: BIOTIN OPERON REPRESSOR + BIOTIN--[ACETYL-COA-CARBOXYLASE] SYNTHETASE (BIOTIN--PROTEIN LIGAS | 0.0753 | 0 | 0.5 |
Trypanosoma cruzi | Biotin--acetyl-CoA-carboxylase ligase, putative | 0.106 | 0.0755 | 0.5 |
Entamoeba histolytica | hypothetical protein, conserved | 0.1445 | 0.1702 | 1 |
Wolbachia endosymbiont of Brugia malayi | biotin-(acetyl-CoA carboxylase) ligase | 0.106 | 0.0755 | 0.5 |
Entamoeba histolytica | hypothetical protein, conserved | 0.1445 | 0.1702 | 1 |
Treponema pallidum | biotin--acetyl-CoA-carboxylase ligase | 0.4822 | 1 | 0.5 |
Entamoeba histolytica | hypothetical protein, conserved | 0.1445 | 0.1702 | 1 |
Entamoeba histolytica | hypothetical protein, conserved | 0.1445 | 0.1702 | 1 |
Echinococcus granulosus | N terminal of biotin protein ligase | 0.1445 | 0.1702 | 1 |
Trypanosoma brucei | Biotin--acetyl-CoA-carboxylase ligase, putative | 0.106 | 0.0755 | 0.5 |
Mycobacterium ulcerans | bifunctional protein BirA | 0.4515 | 0.9245 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.106 | 0.0755 | 0.5 |
Plasmodium falciparum | biotin--acetyl-CoA-carboxylase, putative | 0.106 | 0.0755 | 0.5 |
Chlamydia trachomatis | hypothetical protein | 0.1445 | 0.1702 | 1 |
Entamoeba histolytica | hypothetical protein, conserved | 0.1445 | 0.1702 | 1 |
Schistosoma mansoni | biotin-protein ligase | 0.1445 | 0.1702 | 1 |
Entamoeba histolytica | hypothetical protein, conserved | 0.1445 | 0.1702 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 1 nM | Displacement of [125I]MCP1 from CCR2 in human THP1 cell membranes after 8 hrs by scintillation counting analysis | ChEMBL. | 24900677 |
Ki (binding) | = 50 nM | Displacement of [125I]RANTES from human CCR5 expressed in CHO cell membranes coexpressing Gal6 after 6 hrs by scintillation counting analysis | ChEMBL. | 24900677 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.