Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0041 | 0.0253 | 1 |
Onchocerca volvulus | 0.0008 | 0 | 0.5 | |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0008 | 0.0002 | 0.0084 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0012 | 0.0031 | 0.1219 |
Onchocerca volvulus | 0.0008 | 0 | 0.5 | |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0008 | 0.0002 | 0.0084 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0008 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0031 | 0.0031 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0039 | 0.0233 | 1 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0008 | 0 | 0.5 |
Echinococcus granulosus | potassium:sodium hyperpolarization activated | 0.0008 | 0.0002 | 0.0084 |
Onchocerca volvulus | 0.0008 | 0 | 0.5 | |
Schistosoma mansoni | voltage-gated potassium channel | 0.0008 | 0.0002 | 0.0075 |
Echinococcus multilocularis | potassium:sodium hyperpolarization activated | 0.0008 | 0.0002 | 0.0084 |
Onchocerca volvulus | 0.0008 | 0 | 0.5 | |
Schistosoma mansoni | voltage-gated potassium channel | 0.0012 | 0.0031 | 0.1095 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0008 | 0.0002 | 0.0075 |
Onchocerca volvulus | 0.0008 | 0 | 0.5 | |
Echinococcus granulosus | cyclic nucleotide gated cation channel alpha 3 | 0.0008 | 0.0002 | 0.0084 |
Onchocerca volvulus | 0.0008 | 0 | 0.5 | |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0041 | 0.0253 | 1 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0008 | 0.0002 | 0.0002 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0012 | 0.0031 | 0.1219 |
Onchocerca volvulus | 0.0008 | 0 | 0.5 | |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0008 | 0.0002 | 0.0075 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0045 | 0.0282 | 1 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0012 | 0.0031 | 0.1219 |
Onchocerca volvulus | 0.0008 | 0 | 0.5 | |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0008 | 0.0002 | 0.0075 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0039 | 0.0233 | 1 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0008 | 0.0002 | 0.0075 |
Onchocerca volvulus | 0.0008 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.1329 | 1 | 1 |
Onchocerca volvulus | 0.0008 | 0 | 0.5 | |
Onchocerca volvulus | 0.0008 | 0 | 0.5 | |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0008 | 0.0002 | 0.0084 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0008 | 0.0002 | 0.0002 |
Onchocerca volvulus | 0.0008 | 0 | 0.5 | |
Schistosoma mansoni | voltage-gated potassium channel | 0.0012 | 0.0031 | 0.1095 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0008 | 0.0002 | 0.0084 |
Onchocerca volvulus | 0.0008 | 0 | 0.5 | |
Echinococcus multilocularis | cyclic nucleotide gated cation channel | 0.0008 | 0.0002 | 0.0084 |
Onchocerca volvulus | 0.0008 | 0 | 0.5 | |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0008 | 0.0002 | 0.0084 |
Onchocerca volvulus | 0.0008 | 0 | 0.5 | |
Toxoplasma gondii | hypothetical protein | 0.1329 | 1 | 0.5 |
Onchocerca volvulus | 0.0008 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.1329 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0045 | 0.0282 | 1 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.1329 | 1 | 1 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0041 | 0.0253 | 0.0253 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0008 | 0.0002 | 0.0084 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0012 | 0.0031 | 0.1219 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0041 | 0.0253 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0212 | 0.0212 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0008 | 0.0002 | 0.0075 |
Onchocerca volvulus | 0.0008 | 0 | 0.5 | |
Echinococcus multilocularis | cyclic nucleotide gated cation channel alpha 3 | 0.0008 | 0.0002 | 0.0084 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.0002 | 0.0002 |
Brugia malayi | Cyclic-nucleotide gated cation channel | 0.0008 | 0.0002 | 0.0084 |
Echinococcus granulosus | voltage gated potassium channel | 0.0012 | 0.0031 | 0.1219 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 27.9 uM | Antiproliferative activity against human HCT116 cells assessed as growth inhibition measured after 48 hrs by MTT assay | ChEMBL. | 23260578 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.