Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | prolyl oligopeptidase family protein | 0.0876 | 0.2791 | 0.2791 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.2606 | 1 | 1 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0207 | 0 | 0.5 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0876 | 0.2791 | 0.2791 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0207 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable protease II PtrBb [second part] (oligopeptidase B) | 0.0207 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0207 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.067 | 0.193 | 0.193 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0207 | 0 | 0.5 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0876 | 0.2791 | 1 |
Brugia malayi | hypothetical protein | 0.067 | 0.193 | 0.193 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0207 | 0 | 0.5 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.2606 | 1 | 1 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0876 | 0.2791 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.2606 | 1 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0207 | 0 | 0.5 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0876 | 0.2791 | 1 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0207 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable peptidase | 0.0207 | 0 | 0.5 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.2606 | 1 | 1 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0207 | 0 | 0.5 |
Plasmodium falciparum | peptidase, putative | 0.0207 | 0 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0207 | 0 | 0.5 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0876 | 0.2791 | 1 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0876 | 0.2791 | 1 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0207 | 0 | 0.5 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0876 | 0.2791 | 0.2791 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0207 | 0 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0876 | 0.2791 | 1 |
Trichomonas vaginalis | Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase | 0.0207 | 0 | 0.5 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0207 | 0 | 0.5 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0207 | 0 | 0.5 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0876 | 0.2791 | 0.2791 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.2606 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | Antitubercular activity against Mycobacterium tuberculosis H37Rv ATCC 27294 assessed as growth inhibition at 250 ug/ml measured every 24 hrs by BACTEC radiosusceptibility assay | ChEMBL. | 23369537 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.