Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | HMG-CoA reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | expressed conserved protein | 0.0852 | 0.3046 | 1 |
Toxoplasma gondii | kringle domain-containing protein | 0.0741 | 0.2483 | 0.5 |
Onchocerca volvulus | 0.2225 | 1 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0741 | 0.2483 | 0.2483 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0741 | 0.2483 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0741 | 0.2483 | 0.2483 |
Loa Loa (eye worm) | hypothetical protein | 0.2225 | 1 | 1 |
Onchocerca volvulus | 0.0741 | 0.2483 | 0.2483 | |
Mycobacterium ulcerans | hypothetical protein | 0.0251 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0741 | 0.2483 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.2225 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.2225 | 1 | 1 |
Onchocerca volvulus | 0.1974 | 0.8731 | 0.8731 | |
Echinococcus granulosus | expressed conserved protein | 0.0852 | 0.3046 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2225 | 1 | 1 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0741 | 0.2483 | 0.8152 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0741 | 0.2483 | 0.8152 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0741 | 0.2483 | 0.5 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0741 | 0.2483 | 0.2483 |
Brugia malayi | Protein kinase domain containing protein | 0.0741 | 0.2483 | 0.2483 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0741 | 0.2483 | 0.5 |
Brugia malayi | Kringle domain containing protein | 0.0741 | 0.2483 | 0.2483 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = -4.9 | Ability to inhibit HMG-CoA reductase (HMGR) by cholesterol synthesis inhibition screen (CSI) in rats | ChEMBL. | 2296019 |
IC50 (binding) | = -4.6 | Ability to inhibit HMG-CoA reductase (HMGR) by CoA reductase inhibition screen (COR) in rats | ChEMBL. | 2296019 |
IC50 (binding) | = 12 uM | Ability to inhibit HMG-CoA reductase (HMGR) by cholesterol synthesis inhibition screen (CSI) in rats | ChEMBL. | 2296019 |
IC50 (binding) | = 12 uM | Ability to inhibit HMG-CoA reductase (HMGR) by cholesterol synthesis inhibition screen (CSI) in rats | ChEMBL. | 2296019 |
IC50 (binding) | = 28 uM | Ability to inhibit HMG-CoA reductase (HMGR) by CoA reductase inhibition screen (COR) in rats | ChEMBL. | 2296019 |
IC50 (binding) | = 28 uM | Ability to inhibit HMG-CoA reductase (HMGR) by CoA reductase inhibition screen (COR) in rats | ChEMBL. | 2296019 |
Log IC50 (binding) | = -4.9 | Ability to inhibit HMG-CoA reductase (HMGR) by cholesterol synthesis inhibition screen (CSI) in rats | ChEMBL. | 2296019 |
Log IC50 (binding) | = -4.6 | Ability to inhibit HMG-CoA reductase (HMGR) by CoA reductase inhibition screen (COR) in rats | ChEMBL. | 2296019 |
Relative potency (binding) | = 0.1 | Ratio of inhibitory activity of compound against HMG-CoA reductase to that of compactin | ChEMBL. | 2296019 |
Relative potency (binding) | = 0.1 | Ratio of inhibitory activity of compound against HMG-CoA reductase to that of compactin | ChEMBL. | 2296019 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.