Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glutamate receptor ionotropic kainate 3 | Starlite/ChEMBL | References |
Rattus norvegicus | Glutamate receptor ionotropic kainate 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Glutamate receptor ionotropic kainate 3 | 919 aa | 920 aa | 31.4 % | |
Onchocerca volvulus | Putative 39S ribosomal protein L45, mitochondrial | Glutamate receptor ionotropic kainate 3 | 919 aa | 834 aa | 31.7 % |
Drosophila melanogaster | Glutamate receptor IA | Glutamate receptor ionotropic kainate 1 | 949 aa | 913 aa | 34.5 % |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | Glutamate receptor ionotropic kainate 3 | 919 aa | 969 aa | 27.6 % |
Drosophila melanogaster | NMDA receptor 2 | Glutamate receptor ionotropic kainate 3 | 919 aa | 833 aa | 23.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | glutamate receptor 1 | 0.0061 | 0.1126 | 0.5 |
Echinococcus granulosus | glutamate receptor ionotropic kainate 3 | 0.0097 | 0.4883 | 0.4883 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0147 | 1 | 1 |
Schistosoma mansoni | glutamate receptor kainate | 0.0135 | 0.8816 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0147 | 1 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0072 | 0.231 | 0.231 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0061 | 0.1126 | 0.5 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0072 | 0.231 | 0.154 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0061 | 0.1126 | 0.1126 |
Schistosoma mansoni | glutamate receptor kainate | 0.0135 | 0.8816 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0061 | 0.1126 | 0.1126 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0147 | 1 | 1 |
Echinococcus granulosus | glutamate receptor ionotropic kainate | 0.0097 | 0.4883 | 0.4883 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0072 | 0.231 | 0.231 |
Echinococcus granulosus | glutamate receptor 2 | 0.0072 | 0.231 | 0.231 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0147 | 1 | 1 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0072 | 0.231 | 0.231 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0061 | 0.1126 | 0.1126 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0147 | 1 | 1 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0061 | 0.1126 | 0.5 |
Echinococcus multilocularis | glutamate receptor ionotropic kainate | 0.0097 | 0.4883 | 0.4883 |
Echinococcus multilocularis | NMDA receptor | 0.0097 | 0.4883 | 0.4883 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0061 | 0.1126 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0097 | 0.4883 | 0.4883 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.382 uM | Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluKK1(Q)1b receptor expressed in sf9 cells by liquid scintillation counting | ChEMBL. | 23414088 |
Ki (binding) | = 5.66 uM | Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluK3 receptor expressed in sf9 cells by liquid scintillation counting | ChEMBL. | 23414088 |
Ki (binding) | = 53.3 uM | Displacement of [3H]AMPA from full length recombinant rat GluKA2(R) receptor expressed in sf9 cells by liquid scintillation counting | ChEMBL. | 23414088 |
Ki (binding) | > 100 uM | Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluKK2(VCR) receptor expressed in sf9 cells by liquid scintillation counting | ChEMBL. | 23414088 |
Ki (binding) | > 100 uM | Displacement of [3H]CGP39653 from NMDA receptor in rat brain cortex after 60 mins by Packard TopCount microplate scintillator counting | ChEMBL. | 23414088 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.