TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 368.84 | Formula: C18H13ClN4OS
H donors: 1 H acceptors: 1 LogP: 5.22 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccccc1NCn1nc(oc1=S)c1ccc2c(n1)cccc2
InChi: 1S/C18H13ClN4OS/c19-13-6-2-4-8-15(13)20-11-23-18(25)24-17(22-23)16-10-9-12-5-1-3-7-14(12)21-16/h1-10,20H,11H2
InChiKey: NQOCJFRPGPKRDU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	telomerase reverse transcriptase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Babesia bovis	conserved hypothetical protein	Get druggable targets OG5_131652	All targets in OG5_131652
Candida albicans	telomerase reverse transcriptase	Get druggable targets OG5_131652	All targets in OG5_131652
Theileria parva	hypothetical protein	Get druggable targets OG5_131652	All targets in OG5_131652
Candida albicans	telomerase reverse transcriptase	Get druggable targets OG5_131652	All targets in OG5_131652
Brugia malayi	Telomerase reverse transcriptase	Get druggable targets OG5_131652	All targets in OG5_131652
Onchocerca volvulus	Telomerase reverse transcriptase homolog	Get druggable targets OG5_131652	All targets in OG5_131652

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	conserved hypothetical protein	0.0313	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0789	1	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0476	0.343	0.343
Echinococcus multilocularis	tensin	0.0476	0.343	0.343
Loa Loa (eye worm)	STAT protein	0.0476	0.343	0.343
Loa Loa (eye worm)	TK/FER protein kinase	0.0789	1	1
Echinococcus granulosus	tensin	0.0476	0.343	0.343
Echinococcus multilocularis	NCK adaptor protein	0.0476	0.343	0.343
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0313	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0789	1	1
Trypanosoma cruzi	protein kinase, putative	0.0313	0	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0789	1	1
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0476	0.343	0.343
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0789	1	1
Plasmodium falciparum	protein kinase, putative	0.0313	0	0.5
Echinococcus granulosus	SH2 domain containing protein 7	0.0476	0.343	0.343
Loa Loa (eye worm)	SH2 domain-containing protein	0.0476	0.343	0.343
Echinococcus granulosus	c src tyrosine kinase	0.0789	1	1
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0476	0.343	0.343
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Trichomonas vaginalis	STE family protein kinase	0.0313	0	0.5
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0789	1	1
Schistosoma mansoni	tensin	0.0476	0.343	0.343
Loa Loa (eye worm)	TK/FER protein kinase	0.0789	1	1
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0313	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Trichomonas vaginalis	TK family protein kinase	0.0313	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0789	1	1
Onchocerca volvulus		0.0476	0.343	0.343
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0789	1	1
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0789	1	1
Giardia lamblia	Kinase, NEK	0.0313	0	0.5
Leishmania major	hypothetical protein, conserved	0.0313	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0789	1	1
Brugia malayi	hypothetical protein	0.0476	0.343	0.343
Plasmodium falciparum	protein kinase, putative	0.0313	0	0.5
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0476	0.343	0.343
Onchocerca volvulus		0.0476	0.343	0.343
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0476	0.343	0.343
Brugia malayi	hypothetical protein	0.0789	1	1
Onchocerca volvulus		0.0789	1	1
Echinococcus granulosus	NCK adaptor protein	0.0476	0.343	0.343
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0476	0.343	0.343
Toxoplasma gondii	protein kinase	0.0313	0	0.5
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0476	0.343	0.343
Leishmania major	protein kinase, putative	0.0313	0	0.5
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0313	0	0.5
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0476	0.343	0.343
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0789	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Schistosoma mansoni	hypothetical protein	0.0476	0.343	0.343
Onchocerca volvulus		0.0789	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0476	0.343	0.343
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0476	0.343	0.343
Onchocerca volvulus		0.0789	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Schistosoma mansoni	adapter molecule crk	0.0476	0.343	0.343
Schistosoma mansoni	tyrosine kinase	0.0789	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Toxoplasma gondii	STE kinase	0.0313	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0789	1	1
Trypanosoma brucei	protein kinase, putative	0.0313	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0313	0	0.5
Loa Loa (eye worm)	SH2 domain-containing protein	0.0476	0.343	0.343
Loa Loa (eye worm)	hypothetical protein	0.0476	0.343	0.343
Plasmodium falciparum	protein kinase, putative	0.0313	0	0.5
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0313	0	0.5
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0476	0.343	0.343
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0313	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0313	0	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0789	1	1
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0789	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0313	0	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0313	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0789	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Onchocerca volvulus		0.0476	0.343	0.343
Loa Loa (eye worm)	SH2 domain-containing protein	0.0476	0.343	0.343
Schistosoma mansoni	tensin-related	0.0476	0.343	0.343
Echinococcus multilocularis	SH2 motif	0.0476	0.343	0.343
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0476	0.343	0.343
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0789	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0476	0.343	0.343
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0476	0.343	0.343
Schistosoma mansoni	tyrosine kinase	0.0789	1	1
Echinococcus multilocularis		0.0476	0.343	0.343
Loa Loa (eye worm)	SRC-1	0.0789	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0789	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0313	0	0.5
Echinococcus granulosus	signal transduction protein lnk realted	0.0476	0.343	0.343
Trichomonas vaginalis	conserved hypothetical protein	0.0313	0	0.5
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0476	0.343	0.343
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Schistosoma mansoni	GTPase activating protein	0.0476	0.343	0.343
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0476	0.343	0.343
Schistosoma mansoni	suppressor of cytokine signaling	0.0476	0.343	0.343
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0789	1	1
Echinococcus granulosus	tyrosine kinase	0.0789	1	1
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0789	1	1
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0476	0.343	0.343
Echinococcus granulosus	tyrosine protein kinase Srms	0.0789	1	1
Echinococcus multilocularis	tyrosine kinase	0.0789	1	1
Onchocerca volvulus		0.0476	0.343	0.343
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0476	0.343	0.343
Schistosoma mansoni	shc transforming protein	0.0476	0.343	0.343
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0476	0.343	0.343
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0789	1	1
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0476	0.343	0.343
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0476	0.343	0.343
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0476	0.343	0.343
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0476	0.343	0.343
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Schistosoma mansoni	tensin-related	0.0476	0.343	0.343
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Brugia malayi	SH2 domain containing protein	0.0789	1	1
Brugia malayi	SH2 domain containing protein	0.0476	0.343	0.343
Loa Loa (eye worm)	hypothetical protein	0.0789	1	1
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0476	0.343	0.343
Echinococcus granulosus	SHC transforming protein 3	0.0476	0.343	0.343
Loa Loa (eye worm)	hypothetical protein	0.0476	0.343	0.343
Echinococcus multilocularis	tyrosine protein kinase shark	0.0789	1	1
Loa Loa (eye worm)	hypothetical protein	0.0476	0.343	0.343
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0476	0.343	0.343
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Giardia lamblia	Kinase, NEK	0.0313	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0476	0.343	0.343
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0313	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0476	0.343	0.343
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0789	1	1
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0476	0.343	0.343
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0789	1	1
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0789	1	1
Schistosoma mansoni	suppressor of cytokine signaling	0.0476	0.343	0.343
Echinococcus granulosus	SH2 motif	0.0476	0.343	0.343
Loa Loa (eye worm)	TK/FER protein kinase	0.0789	1	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0313	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0476	0.343	0.343
Loa Loa (eye worm)	hypothetical protein	0.0476	0.343	0.343
Schistosoma mansoni	signal transduction protein lnk-related	0.0476	0.343	0.343
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0789	1	1
Schistosoma mansoni	tensin	0.0476	0.343	0.343
Echinococcus multilocularis	SH2 domain containing protein 7	0.0476	0.343	0.343
Giardia lamblia	Kinase	0.0313	0	0.5
Onchocerca volvulus	Telomerase reverse transcriptase homolog	0.0376	0.1323	0.1323
Onchocerca volvulus		0.0789	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0476	0.343	0.343
Trichomonas vaginalis	conserved hypothetical protein	0.0313	0	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0313	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0789	1	1
Brugia malayi	Tyrosine-protein kinase abl-1	0.0789	1	1
Loa Loa (eye worm)	hypothetical protein	0.0476	0.343	0.343
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0313	0	0.5
Brugia malayi	SH2 domain containing protein	0.0476	0.343	0.343
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0476	0.343	0.343
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0789	1	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0789	1	1
Brugia malayi	protein-tyrosine kinase	0.0789	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0789	1	1
Trichomonas vaginalis	AGC family protein kinase	0.0313	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0789	1	1
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0476	0.343	0.343
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Echinococcus granulosus	tyrosine protein kinase Blk	0.0789	1	1
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0313	0	0.5
Schistosoma mansoni	SH2A	0.0476	0.343	0.343
Entamoeba histolytica	SH2 domain containing protein	0.0476	0.343	0.343
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0789	1	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0476	0.343	0.343
Schistosoma mansoni	growth factor receptor-bound protein	0.0476	0.343	0.343
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Onchocerca volvulus		0.0789	1	1
Brugia malayi	SH2 domain containing protein	0.0476	0.343	0.343
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Brugia malayi	RhoGAP domain containing protein	0.0476	0.343	0.343
Loa Loa (eye worm)	hypothetical protein	0.0476	0.343	0.343
Brugia malayi	SRC-1	0.0789	1	1
Trypanosoma brucei	Pseudokinase, putative	0.0313	0	0.5
Giardia lamblia	Protein 21.1	0.0313	0	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0789	1	1
Loa Loa (eye worm)	hypothetical protein	0.0476	0.343	0.343
Echinococcus multilocularis	signal transduction protein lnk realted	0.0476	0.343	0.343
Brugia malayi	SH2 domain containing protein	0.0476	0.343	0.343
Brugia malayi	Variant SH3 domain containing protein	0.0476	0.343	0.343
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Schistosoma mansoni	nck2/grb4	0.0476	0.343	0.343
Echinococcus granulosus	tyrosine kinase	0.0789	1	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0476	0.343	0.343
Plasmodium vivax	protein kinase, putative	0.0313	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0313	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Trypanosoma cruzi	protein kinase, putative	0.0313	0	0.5
Trichomonas vaginalis	protein kinase atn1, putative	0.0313	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0789	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0476	0.343	0.343
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Brugia malayi	SH2 domain containing protein	0.0476	0.343	0.343
Leishmania major	protein kinase, putative	0.0313	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0476	0.343	0.343
Echinococcus granulosus	hypothetical protein	0.0476	0.343	0.343
Brugia malayi	Protein kinase domain containing protein	0.0789	1	1
Echinococcus multilocularis	SHC transforming protein 3	0.0476	0.343	0.343
Echinococcus multilocularis	tensin	0.0476	0.343	0.343
Brugia malayi	Protein kinase domain containing protein	0.0789	1	1
Schistosoma mansoni	hypothetical protein	0.0476	0.343	0.343
Echinococcus granulosus	tyrosine protein kinase shark	0.0789	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Loa Loa (eye worm)	TK protein kinase	0.0789	1	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0476	0.343	0.343
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Onchocerca volvulus		0.0476	0.343	0.343
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0476	0.343	0.343
Onchocerca volvulus		0.0476	0.343	0.343
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0789	1	1
Schistosoma mansoni	tyrosine kinase	0.0789	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0789	1	1
Toxoplasma gondii	protein kinase domain-containing protein	0.0313	0	0.5
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0476	0.343	0.343
Brugia malayi	SH2 domain containing protein	0.0476	0.343	0.343
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Loa Loa (eye worm)	TK/ABL protein kinase	0.0789	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0313	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0476	0.343	0.343
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0476	0.343	0.343
Brugia malayi	SH2 domain containing protein	0.0476	0.343	0.343
Echinococcus granulosus	N chimaerin	0.0476	0.343	0.343
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0313	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0789	1	1
Echinococcus granulosus	growth factor receptor bound protein 2	0.0476	0.343	0.343
Plasmodium falciparum	tyrosine kinase-like protein	0.0313	0	0.5
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0476	0.343	0.343
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0313	0	0.5
Schistosoma mansoni	tensin	0.0476	0.343	0.343
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0476	0.343	0.343
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Schistosoma mansoni	growth factor receptor-bound protein	0.0476	0.343	0.343
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Onchocerca volvulus		0.0789	1	1
Echinococcus granulosus	SH2 motif	0.0476	0.343	0.343
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0789	1	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0789	1	1
Brugia malayi	Variant SH3 domain containing protein	0.0476	0.343	0.343
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0313	0	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0476	0.343	0.343
Brugia malayi	Tensin	0.0476	0.343	0.343
Echinococcus granulosus	expressed conserved protein	0.0476	0.343	0.343
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0789	1	1
Brugia malayi	Sex muscle abnormal protein 5	0.0476	0.343	0.343
Schistosoma mansoni	tyrosine kinase	0.0789	1	1
Brugia malayi	SH2 domain containing protein	0.0789	1	1
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0476	0.343	0.343
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0313	0	0.5
Echinococcus multilocularis	SH2 motif	0.0476	0.343	0.343
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Schistosoma mansoni	vav2	0.0476	0.343	0.343
Echinococcus multilocularis	N chimaerin	0.0476	0.343	0.343
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0789	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0476	0.343	0.343
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0476	0.343	0.343
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0789	1	1
Loa Loa (eye worm)	hypothetical protein	0.0476	0.343	0.343
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0789	1	1
Echinococcus multilocularis	c src tyrosine kinase	0.0789	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Echinococcus multilocularis	SH2 motif	0.0476	0.343	0.343
Trichomonas vaginalis	TKL family protein kinase	0.0313	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0789	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 5.5 uM	Inhibition of telomerase in human HepG2 cells after 48 hrs by TRAP-PCR-ELISA	ChEMBL.	23279864
IC50 (functional)	= 24.8 uM	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay	ChEMBL.	23279864

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2312627

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1736865