Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | WD40 repeat protein | 0.1501 | 1 | 1 |
Echinococcus granulosus | wd40 repeat | 0.0243 | 0.0752 | 0.0752 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.0752 | 0.0752 |
Brugia malayi | Hypothetical WD-repeat protein F21H12.1 in chromosome II | 0.0243 | 0.0752 | 0.0752 |
Trichomonas vaginalis | retinoblastoma binding protein, putative | 0.0243 | 0.0752 | 0.0752 |
Onchocerca volvulus | 0.1501 | 1 | 0.5 | |
Plasmodium falciparum | SPRY domain, putative | 0.0141 | 0 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0141 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0243 | 0.0752 | 0.0752 |
Echinococcus multilocularis | wd40 repeat | 0.0243 | 0.0752 | 0.0752 |
Echinococcus multilocularis | protein will die slowly | 0.1501 | 1 | 1 |
Echinococcus granulosus | protein will die slowly | 0.1501 | 1 | 1 |
Schistosoma mansoni | retinoblastoma binding protein | 0.0243 | 0.0752 | 0.0752 |
Trichomonas vaginalis | WD repeat domain, putative | 0.1501 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.1501 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 6.3 uM | Antitubercular activity against Mycobacterium tuberculosis H37Rv ATCC27294 assessed as complete cessation of growth | ChEMBL. | 23211970 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.