Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0419 | 1 | 0.5 | |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0419 | 1 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.0419 | 1 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0419 | 1 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0419 | 1 | 0.5 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0419 | 1 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0419 | 1 | 0.5 |
Loa Loa (eye worm) | lipase | 0.0419 | 1 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0419 | 1 | 0.5 |
Mycobacterium tuberculosis | 4,9-DHSA hydrolase | 0.0404 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0419 | 1 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.0419 | 1 | 0.5 |
Mycobacterium ulcerans | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD | 0.041 | 0.4365 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.