Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | stearoyl-CoA desaturase (delta-9-desaturase) | Starlite/ChEMBL | References |
Mus musculus | stearoyl-Coenzyme A desaturase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | transient receptor potential cation channel | 0.0131 | 0.0485 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.0000035058 | 0.0000043176 |
Brugia malayi | acyl-CoA desaturase | 0.0205 | 0.812 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0223 | 1 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0127 | 0 | 0.5 |
Toxoplasma gondii | transporter, cation channel family protein | 0.0127 | 0 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0127 | 0.0000035058 | 0.0001 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0127 | 0 | 0.5 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.0127 | 0 | 0.5 |
Leishmania major | fatty-acid desaturase, putative | 0.0223 | 1 | 1 |
Onchocerca volvulus | 0.0223 | 1 | 1 | |
Schistosoma mansoni | transient receptor potential channel | 0.0127 | 0.0000035058 | 0.0001 |
Onchocerca volvulus | 0.0223 | 1 | 1 | |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.0205 | 0.812 | 1 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.0223 | 1 | 1 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.0205 | 0.812 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0127 | 0 | 0.5 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0131 | 0.0485 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0205 | 0.812 | 0.812 |
Brugia malayi | olfactory channel protein osm-9 | 0.0131 | 0.0485 | 0.0598 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.0485 | 0.0598 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.0127 | 0 | 0.5 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0131 | 0.0485 | 0.9999 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.0205 | 0.812 | 0.5 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0127 | 0.0000035058 | 0.0001 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0131 | 0.0485 | 0.9999 |
Schistosoma mansoni | transient receptor potential channel | 0.0127 | 0.0000035058 | 0.0001 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0127 | 0.0000035058 | 0.0001 |
Schistosoma mansoni | transient receptor potential channel | 0.0131 | 0.0485 | 1 |
Toxoplasma gondii | transporter, cation channel family protein | 0.0127 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0127 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.0000035058 | 0.0000043176 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0131 | 0.0485 | 1 |
Toxoplasma gondii | transporter, cation channel family protein | 0.0127 | 0 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0205 | 0.812 | 0.812 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 11 nM | Inhibition of SCD1 in ICR mouse liver microsome using [9,10 3H]- stearoyl-Coenzyme A substrate assessed as decreased production of tritiated water after 20 hrs by scintillation counting analysis | ChEMBL. | 23245208 |
IC50 (binding) | = 70 nM | Inhibition of SCD1 in human HepG2 cells using [14C]-stearate substrate assessed as decreased production of [14C]-oleic acid after 24 hrs | ChEMBL. | 23245208 |
Inhibition (binding) | Inhibition of delta5 desaturase in Sprague-Dawley rat liver microsome at 10 uM | ChEMBL. | 23245208 | |
Inhibition (binding) | Inhibition of delta6 desaturase in Sprague-Dawley rat liver microsome using cis,cis-9,12-octadecadienoic acid substrate at 10 uM | ChEMBL. | 23245208 | |
Papp (ADMET) | = 23 ucm/s | Apparent permeability from basolateral to apical side in human Caco2 cells | ChEMBL. | 23245208 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.