Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | serine:threonine protein kinase TAO1 | 0.0802 | 0.5 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0802 | 0.5 | 0.5 |
Loa Loa (eye worm) | STE/STE20/TAO protein kinase | 0.0802 | 0.5 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase TAO1 | 0.0802 | 0.5 | 0.5 |
Brugia malayi | Serine/threonine-protein kinase SULU | 0.0802 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | = 22 % | Cytotoxicity against human HCT15 cells assessed as growth inhibition at 1 x 10 '-5 M after 24 hrs by MTT assay | ChEMBL. | 23202484 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.