Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cholinergic receptor, muscarinic 3 | Starlite/ChEMBL | References |
Homo sapiens | cholinergic receptor, muscarinic 1 | Starlite/ChEMBL | References |
Homo sapiens | cholinergic receptor, muscarinic 5 | Starlite/ChEMBL | References |
Homo sapiens | cholinergic receptor, muscarinic 4 | Starlite/ChEMBL | References |
Homo sapiens | cholinergic receptor, muscarinic 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133264 | All targets in OG5_133264 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133264 | All targets in OG5_133264 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glucosylceramidase, putative | 0.052 | 0.3563 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.052 | 0.3563 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.052 | 0.3563 | 1 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0341 | 0 | 0.5 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0727 | 0.7683 | 0.7613 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.052 | 0.3563 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.036 | 0.0366 | 0.1027 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0727 | 0.7683 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0514 | 0.3447 | 0.433 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.052 | 0.3563 | 1 |
Mycobacterium ulcerans | alpha-L-fucosidase | 0.0843 | 1 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.052 | 0.3563 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0514 | 0.3447 | 0.433 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.036 | 0.0366 | 0.1027 |
Echinococcus multilocularis | fucosidase, alpha L 1, tissue | 0.0843 | 1 | 1 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.052 | 0.3563 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0727 | 0.7683 | 0.7613 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.052 | 0.3563 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = -7.14 | Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M4 in transfected CHO cells. | ChEMBL. | 12086495 |
Ki (binding) | = -5.95 | Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M5 in transfected CHO cells. | ChEMBL. | 12086495 |
Ki (binding) | = -5.93 | Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M1 in transfected CHO cells. | ChEMBL. | 12086495 |
Ki (binding) | = -5.87 | Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells. | ChEMBL. | 12086495 |
Ki (binding) | = -5.86 | Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M3 in transfected CHO cells. | ChEMBL. | 12086495 |
Log Ki (binding) | = 5.86 | Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M3 in transfected CHO cells. | ChEMBL. | 12086495 |
Log Ki (binding) | = 5.87 | Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells. | ChEMBL. | 12086495 |
Log Ki (binding) | = 5.93 | Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M1 in transfected CHO cells. | ChEMBL. | 12086495 |
Log Ki (binding) | = 5.95 | Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M5 in transfected CHO cells. | ChEMBL. | 12086495 |
Log Ki (binding) | = 7.14 | Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M4 in transfected CHO cells. | ChEMBL. | 12086495 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.