Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | valosin containing protein | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0934 | 0.0934 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0077 | 1 | 1 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0077 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 1 | 1 |
Loa Loa (eye worm) | vesicle-fusing ATPase | 0.002 | 0.0934 | 0.0934 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.0034 | 0.3168 | 0.3168 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0077 | 1 | 1 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0077 | 1 | 1 |
Brugia malayi | valosin containing protein | 0.002 | 0.0934 | 0.0934 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0077 | 1 | 1 |
Toxoplasma gondii | cell division protein CDC48CY | 0.0034 | 0.3168 | 0.241 |
Brugia malayi | vesicle-fusing ATPase | 0.002 | 0.0934 | 0.0934 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0077 | 1 | 1 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0077 | 1 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0077 | 1 | 1 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0077 | 1 | 0.5 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0077 | 1 | 1 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0077 | 1 | 1 |
Mycobacterium ulcerans | ATPase | 0.002 | 0.0999 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0077 | 1 | 1 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0077 | 1 | 1 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0077 | 1 | 1 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0077 | 1 | 1 |
Plasmodium vivax | RNA helicase-1, putative | 0.0077 | 1 | 1 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0077 | 1 | 1 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0077 | 1 | 1 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0034 | 0.3168 | 0.3168 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0077 | 1 | 1 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0077 | 1 | 1 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0077 | 1 | 1 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0032 | 0.289 | 0.289 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0077 | 1 | 1 |
Toxoplasma gondii | cell division protein CDC48AP | 0.002 | 0.0999 | 0.0000023607 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.071 uM | Inhibition of human recombinant His-GST tagged VCP expressed in baculovirus infected Hi5 cells assessed as ADP formation incubated for 20 mins proir to substrate addition measured after 90 mins by NADH coupled assay | ChEMBL. | 23245311 |
IC50 (functional) | = 1.37 uM | Cytotoxicity against human HCT116 cells after 72 hrs by luciferase reporter gene assay | ChEMBL. | 23245311 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 23245311 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.