pI: 4.6453 |
Length (AA): 815 |
MW (Da): 90839 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
23 | 787 | 5c1b (A) | 22 | 770 | 69.00 | 0 | 1 | 1.70065 | -0.51 |
23 | 186 | 4rv0 (A) | 19 | 181 | 55.00 | 0 | 1 | 0.876227 | -0.94 |
202 | 435 | 3whk (A) | 178 | 414 | 49.00 | 0 | 1 | 0.932717 | -1.03 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | 4 hs Ring, 16 hs Trophozoite, Erthyrocytic stages, Female gametocyte. | Otto TD Yeoh LM |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Gametocyte, 22 hs Schizont, Male gametocyte. | Otto TD Yeoh LM |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Ookinete. | Otto TD |
Otto TD | A comprehensive evaluation of rodent malaria parasite genomes and gene expression. |
Yeoh LM | Comparative transcriptomics of female and male gametocytes in Plasmodium berghei and the evolution of sex in alveolates. |
Ortholog group members (OG5_126926)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G09840 | cell division control protein 48-A |
Arabidopsis thaliana | AT5G03340 | cell division control protein 48C |
Arabidopsis thaliana | AT3G53230 | cell division control protein 48-B |
Babesia bovis | BBOV_IV008360 | cell division control protein 48, putative |
Babesia bovis | BBOV_IV001700 | cell division cycle protein ATPase, putative |
Brugia malayi | Bm1_55480 | transitional endoplasmic reticulum ATPase TER94, putative |
Candida albicans | CaO19.2340 | microsomal protein of CDC48 family of ATPases |
Candida albicans | CaO19.9876 | microsomal protein of CDC48 family of ATPases |
Caenorhabditis elegans | CELE_C41C4.8 | Protein CDC-48.2 |
Caenorhabditis elegans | CELE_C06A1.1 | Protein CDC-48.1 |
Cryptosporidium hominis | Chro.10043 | cell division cycle protein 48 |
Cryptosporidium parvum | cgd1_330 | CDC48 like AAA ATPase ortholog |
Dictyostelium discoideum | DDB_G0288065 | CDC48 family AAA ATPase |
Drosophila melanogaster | Dmel_CG2331 | CG2331 gene product from transcript CG2331-RA |
Echinococcus granulosus | EgrG_000471600 | transitional endoplasmic reticulum atpase |
Entamoeba histolytica | EHI_045120 | transitional endoplasmic reticulum ATPase, putative |
Entamoeba histolytica | EHI_176970 | cdc48-like protein, putative |
Echinococcus multilocularis | EmuJ_000471600 | transitional endoplasmic reticulum atpase |
Echinococcus multilocularis | EmuJ_000471200 | transitional endoplasmic reticulum atpase |
Giardia lamblia | GL50803_16867 | AAA family ATPase |
Homo sapiens | ENSG00000165280 | valosin containing protein |
Leishmania braziliensis | LbrM.35.1490 | Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog |
Leishmania donovani | LdBPK_361420.1 | Valosin-containing protein, putative |
Leishmania infantum | LinJ.36.1420 | Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog |
Leishmania major | LmjF.36.1370 | Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog |
Leishmania mexicana | LmxM.36.1370 | Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog |
Loa Loa (eye worm) | LOAG_12115 | VCP protein |
Mus musculus | ENSMUSG00000028452 | valosin containing protein |
Mycobacterium tuberculosis | Rv0435c | Putative conserved ATPase |
Mycobacterium ulcerans | MUL_1384 | ATPase |
Neospora caninum | NCLIV_034460 | hypothetical protein |
Neospora caninum | NCLIV_004280 | hypothetical protein |
Oryza sativa | 4345563 | Os08g0413000 |
Oryza sativa | 4331645 | Os03g0151800 |
Onchocerca volvulus | OVOC10958 | Transitional endoplasmic reticulum ATPase homolog |
Plasmodium berghei | PBANKA_1118600 | cell division cycle protein 48 homologue, putative |
Plasmodium falciparum | PF3D7_0619400 | cell division cycle protein 48 homologue, putative |
Plasmodium knowlesi | PKNH_1131000 | cell division cycle protein 48 homologue, putative |
Plasmodium vivax | PVX_088085 | cell division cycle ATPase, putative |
Plasmodium vivax | PVX_114095 | cell division cycle protein 48 homologue, putative |
Plasmodium yoelii | PY03639 | cell division cycle protein 48 homolog |
Saccharomyces cerevisiae | YDL126C | AAA family ATPase CDC48 |
Schistosoma japonicum | Sjp_0085890 | ko:K01509 adenosinetriphosphatase [EC3.6.1.3], putative |
Schistosoma japonicum | Sjp_0119040 | Transitional endoplasmic reticulum ATPase homolog 2, putative |
Schistosoma mansoni | Smp_018240.1 | cell division control protein 48 aaa family protein |
Schistosoma mansoni | Smp_018240.3 | cell division control protein 48 aaa family protein |
Schistosoma mansoni | Smp_018240.4 | cell division control protein 48 aaa family protein |
Schmidtea mediterranea | mk4.000105.16 | |
Schmidtea mediterranea | mk4.001497.01 | Transitional endoplasmic reticulum ATPase |
Schmidtea mediterranea | mk4.003445.02 | Transitional endoplasmic reticulum ATPase |
Schmidtea mediterranea | mk4.001265.01 | Transitional endoplasmic reticulum ATPase |
Schmidtea mediterranea | mk4.001265.00 | |
Schmidtea mediterranea | mk4.000565.09 | Transitional endoplasmic reticulum ATPase |
Schmidtea mediterranea | mk4.000727.02 | Transitional endoplasmic reticulum ATPase |
Trypanosoma brucei gambiense | Tbg972.10.7000 | valosin-containing protein homolog,Transitional endoplasmic reticulum ATPase, putative |
Trypanosoma brucei | Tb927.10.5770 | Valosin-containing protein |
Trypanosoma congolense | TcIL3000_10_4820 | Valosin-containing protein, putative |
Trypanosoma cruzi | TcCLB.509733.170 | Valosin-containing protein, putative |
Toxoplasma gondii | TGME49_321640 | cell division protein CDC48AP |
Toxoplasma gondii | TGME49_273090 | cell division protein CDC48CY |
Toxoplasma gondii | TGME49_324300 | transitional endoplasmic reticulum ATPase, putative |
Theileria parva | TP01_0937 | cell division cycle protein 48, putative |
Theileria parva | TP03_0490 | cell division cycle protein 48, putative |
Trichomonas vaginalis | TVAG_318870 | spermatogenesis associated factor, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.5770 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.5770 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.5770 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.5770 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_C06A1.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_C06A1.1 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_C06A1.1 | Caenorhabditis elegans | slow growth | wormbase |
CELE_C06A1.1 | Caenorhabditis elegans | sterile | wormbase |
CELE_C41C4.8 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_C41C4.8 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_C41C4.8 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_C41C4.8 | Caenorhabditis elegans | slow growth | wormbase |
CELE_C41C4.8 | Caenorhabditis elegans | sterile | wormbase |
YDL126C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1118600 this record | Plasmodium berghei | Essential | plasmo |
TGME49_321640 | Toxoplasma gondii | Probably essential | sidik |
TGME49_273090 | Toxoplasma gondii | Probably essential | sidik |
TGME49_324300 | Toxoplasma gondii | Probably essential | sidik |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | valosin containing protein | Compounds | References |
Mus musculus | valosin containing protein | Compounds | References |