Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | valosin containing protein | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog | 0.0032 | 0.9331 | 1 |
Plasmodium falciparum | cell division cycle protein 48 homologue, putative | 0.0032 | 0.9331 | 0.5 |
Mycobacterium ulcerans | ATPase | 0.002 | 0.4785 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0008 | 0.0113 | 0.0113 |
Trichomonas vaginalis | 26S protease regulatory subunit S10b, putative | 0.0008 | 0.0083 | 0.0083 |
Giardia lamblia | AAA family ATPase | 0.002 | 0.4785 | 0.5 |
Entamoeba histolytica | cdc48-like protein, putative | 0.0032 | 0.9331 | 0.5 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0034 | 1 | 1 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0032 | 0.9331 | 0.9331 |
Onchocerca volvulus | Transitional endoplasmic reticulum ATPase homolog | 0.0034 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.00000076963 | 0.0000016626 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0008 | 0.00000076963 | 0.00000076963 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.0034 | 1 | 1 |
Brugia malayi | vesicle-fusing ATPase | 0.002 | 0.4629 | 1 |
Brugia malayi | valosin containing protein | 0.002 | 0.4629 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.00000076963 | 0.0000016626 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.0113 | 0.0244 |
Trichomonas vaginalis | spermatogenesis associated factor, putative | 0.0034 | 1 | 1 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0008 | 0.0113 | 0.0113 |
Schistosoma mansoni | transient receptor potential channel | 0.0008 | 0.0113 | 0.0113 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0014 | 0.2383 | 0.2383 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0008 | 0.0113 | 0.0113 |
Toxoplasma gondii | cell division protein CDC48CY | 0.0034 | 1 | 1 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0008 | 0.00000076963 | 0.00000076963 |
Toxoplasma gondii | cell division protein CDC48AP | 0.002 | 0.4785 | 0.4785 |
Brugia malayi | transitional endoplasmic reticulum ATPase TER94, putative | 0.0014 | 0.2383 | 0.5148 |
Plasmodium vivax | cell division cycle protein 48 homologue, putative | 0.0032 | 0.9331 | 1 |
Trypanosoma brucei | Valosin-containing protein | 0.0032 | 0.9331 | 1 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0008 | 0.00000076963 | 0.00000076963 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0008 | 0.0113 | 0.0113 |
Loa Loa (eye worm) | vesicle-fusing ATPase | 0.002 | 0.4629 | 1 |
Trichomonas vaginalis | proteasome-activating nucleotidase, putative | 0.0008 | 0.0083 | 0.0083 |
Mycobacterium tuberculosis | Putative conserved ATPase | 0.002 | 0.4785 | 0.5 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0008 | 0.0113 | 0.0113 |
Trypanosoma cruzi | Valosin-containing protein, putative | 0.0032 | 0.9331 | 1 |
Schistosoma mansoni | transient receptor potential channel | 0.0008 | 0.00000076963 | 0.00000076963 |
Schistosoma mansoni | transient receptor potential channel | 0.0008 | 0.00000076963 | 0.00000076963 |
Loa Loa (eye worm) | VCP protein | 0.0014 | 0.2383 | 0.5148 |
Entamoeba histolytica | transitional endoplasmic reticulum ATPase, putative | 0.0032 | 0.9331 | 0.5 |
Toxoplasma gondii | transitional endoplasmic reticulum ATPase, putative | 0.002 | 0.4785 | 0.4785 |
Brugia malayi | olfactory channel protein osm-9 | 0.0008 | 0.0113 | 0.0244 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.4629 | 1 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.0014 | 0.2383 | 0.2383 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.058 uM | Inhibition of human recombinant His-GST tagged VCP expressed in baculovirus infected Hi5 cells assessed as ADP formation incubated for 20 mins proir to substrate addition measured after 90 mins by NADH coupled assay | ChEMBL. | 23245311 |
IC50 (functional) | = 4.6 uM | Cytotoxicity against human HCT116 cells after 72 hrs by luciferase reporter gene assay | ChEMBL. | 23245311 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 23245311 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.