Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dopamine receptor D2 | Starlite/ChEMBL | References |
Homo sapiens | dopamine receptor D4 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | Serine/threonine-protein kinase NEK16, putative | 0.2053 | 1 | 1 |
Leishmania major | protein kinase, putative | 0.2053 | 1 | 0.5 |
Trypanosoma cruzi | NIMA-related kinase, putative | 0.2053 | 1 | 1 |
Plasmodium vivax | serine/threonine-protein kinase NEK4, putative | 0.2053 | 1 | 0.5 |
Plasmodium falciparum | NIMA related kinase 4 | 0.2053 | 1 | 0.5 |
Toxoplasma gondii | NEK kinase | 0.2053 | 1 | 0.5 |
Leishmania major | serine/threonine-protein kinase, putative | 0.2053 | 1 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase Nek1 | 0.2001 | 0 | 0.5 |
Trypanosoma cruzi | Serine/threonine-protein kinase NEK11, putative | 0.2053 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.2053 | 1 | 0.5 |
Trypanosoma cruzi | Serine/threonine-protein kinase NEK11, putative | 0.2053 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.2053 | 1 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase Nek1 | 0.2001 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2053 | 1 | 0.5 |
Trypanosoma brucei | NIMA-related protein kinase | 0.2053 | 1 | 0.5 |
Trypanosoma brucei | Serine/threonine-protein kinase NEK16, putative | 0.2053 | 1 | 0.5 |
Trypanosoma brucei | Serine/threonine-protein kinase NEK11, putative | 0.2053 | 1 | 0.5 |
Plasmodium falciparum | NIMA related kinase 2 | 0.2053 | 1 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.2053 | 1 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.2053 | 1 | 0.5 |
Toxoplasma gondii | NEK kinase | 0.2053 | 1 | 0.5 |
Giardia lamblia | Kinase, NEK | 0.2053 | 1 | 0.5 |
Plasmodium vivax | serine/threonine-protein kinase Nek1, putative | 0.2053 | 1 | 0.5 |
Leishmania major | protein kinase, putative,serine/threonine-protein kinase Nek1, putative | 0.2053 | 1 | 0.5 |
Toxoplasma gondii | NEK kinase | 0.2053 | 1 | 0.5 |
Trichomonas vaginalis | STE family protein kinase | 0.2053 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 429 nM | Binding affinity towards human Dopamine Receptor D4 was determined via standard competitive displacement assays using [3H]-YM 09151 as radioligand | ChEMBL. | 12372512 |
Ki (binding) | = 429 nM | Binding affinity towards human Dopamine Receptor D4 was determined via standard competitive displacement assays using [3H]-YM 09151 as radioligand | ChEMBL. | 12372512 |
Ki (binding) | = 2610 nM | Binding affinity towards human Dopamine receptor D2 was determined via standard competitive displacement assay using [3H]-YM 09151 as radioligand | ChEMBL. | 12372512 |
Ki (binding) | = 2610 nM | Binding affinity towards human Dopamine receptor D2 was determined via standard competitive displacement assay using [3H]-YM 09151 as radioligand | ChEMBL. | 12372512 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.