Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | arginine vasopressin receptor 1A | Starlite/ChEMBL | References |
Homo sapiens | arginine vasopressin receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | serine:threonine protein kinase Nek1 | 0.0881 | 0 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0904 | 1 | 0.5 |
Trypanosoma brucei | NIMA-related protein kinase | 0.0904 | 1 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0904 | 1 | 0.5 |
Leishmania major | serine/threonine-protein kinase, putative | 0.0904 | 1 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0904 | 1 | 0.5 |
Trypanosoma cruzi | Serine/threonine-protein kinase NEK11, putative | 0.0904 | 1 | 1 |
Trypanosoma cruzi | Serine/threonine-protein kinase NEK11, putative | 0.0904 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase Nek1 | 0.0881 | 0 | 0.5 |
Toxoplasma gondii | NEK kinase | 0.0904 | 1 | 0.5 |
Plasmodium falciparum | NIMA related kinase 4 | 0.0904 | 1 | 0.5 |
Leishmania major | protein kinase, putative | 0.0904 | 1 | 0.5 |
Trypanosoma cruzi | Serine/threonine-protein kinase NEK16, putative | 0.0904 | 1 | 1 |
Plasmodium vivax | serine/threonine-protein kinase NEK4, putative | 0.0904 | 1 | 0.5 |
Trypanosoma cruzi | NIMA-related kinase, putative | 0.0904 | 1 | 1 |
Giardia lamblia | Kinase, NEK | 0.0904 | 1 | 0.5 |
Plasmodium vivax | serine/threonine-protein kinase Nek1, putative | 0.0904 | 1 | 0.5 |
Trichomonas vaginalis | STE family protein kinase | 0.0904 | 1 | 0.5 |
Leishmania major | protein kinase, putative,serine/threonine-protein kinase Nek1, putative | 0.0904 | 1 | 0.5 |
Toxoplasma gondii | NEK kinase | 0.0904 | 1 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0904 | 1 | 0.5 |
Toxoplasma gondii | NEK kinase | 0.0904 | 1 | 0.5 |
Plasmodium falciparum | NIMA related kinase 2 | 0.0904 | 1 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0904 | 1 | 0.5 |
Trypanosoma brucei | Serine/threonine-protein kinase NEK16, putative | 0.0904 | 1 | 0.5 |
Trypanosoma brucei | Serine/threonine-protein kinase NEK11, putative | 0.0904 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7 nM | Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptor | ChEMBL. | 15149662 |
IC50 (binding) | = 7 nM | Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptor | ChEMBL. | 15149662 |
IC50 (binding) | = 10 nM | Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V2 receptor | ChEMBL. | 15149662 |
IC50 (binding) | = 10 nM | Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V2 receptor | ChEMBL. | 15149662 |
IC50 (functional) | = 135 nM | Evaluated for intracellular calcium mobilization in HEK-293 cells transfected to express human vasopressin V1a receptor | ChEMBL. | 15149662 |
IC50 (functional) | = 135 nM | Evaluated for intracellular calcium mobilization in HEK-293 cells transfected to express human vasopressin V1a receptor | ChEMBL. | 15149662 |
IC50 (functional) | = 440 nM | Evaluated for accumulation of cAMP in transfected HEK-293 cells expressing human vasopressin V2 receptor | ChEMBL. | 15149662 |
IC50 (functional) | = 440 nM | Evaluated for accumulation of cAMP in transfected HEK-293 cells expressing human vasopressin V2 receptor | ChEMBL. | 15149662 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.