Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Saccharomyces cerevisiae | acetolactate synthase catalytic subunit | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable oxalyl-CoA decarboxylase OxcA | 0.0133 | 1 | 1 |
Mycobacterium leprae | Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) | 0.0133 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) | 0.0133 | 1 | 1 |
Schistosoma mansoni | acetolactate synthase | 0.0114 | 0.7458 | 0.5 |
Mycobacterium ulcerans | putative oxalyl-CoA decarboxylase | 0.0133 | 1 | 1 |
Mycobacterium ulcerans | acetolactate synthase 1 catalytic subunit | 0.0133 | 1 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0076 | 0.2525 | 0.5 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0076 | 0.2525 | 0.5 |
Loa Loa (eye worm) | ILVBL protein | 0.008 | 0.3106 | 1 |
Schistosoma mansoni | acetolactate synthase | 0.0114 | 0.7458 | 0.5 |
Leishmania major | putative pyruvate/indole-pyruvate carboxylase, putative | 0.0076 | 0.2525 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0133 | 1 | 1 |
Mycobacterium leprae | PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) | 0.0133 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 96 % | Effect on Oryza sativa (rice) plant growth in transplanted Oryza sativa field assessed as number of tillers at 20 g/ha treated after 7 days transplanting | ChEMBL. | No reference |
Activity (ADMET) | = 99 % | Effect on Oryza sativa (rice) plant growth in transplanted Oryza sativa field assessed as number of tillers at 30 g/ha treated after 3 days transplanting | ChEMBL. | No reference |
Activity (ADMET) | = 100 % | Effect on Oryza sativa (rice) plant growth in transplanted Oryza sativa field assessed as number of tillers at 20 g/ha treated after 3 days transplanting | ChEMBL. | No reference |
Activity (ADMET) | = 100 % | Effect on Oryza sativa (rice) plant growth in transplanted Oryza sativa field assessed as number of tillers at 30 g/ha treated after 7 days transplanting | ChEMBL. | No reference |
Activity (ADMET) | = 101 % | Effect on Oryza sativa (rice) plant growth in transplanted Oryza sativa field assessed as plant height at 30 g/ha treated after 15 days transplanting | ChEMBL. | No reference |
Activity (ADMET) | = 101 % | Effect on Oryza sativa (rice) plant growth in transplanted Oryza sativa field assessed as number of tillers at 30 g/ha treated after 10 days transplanting | ChEMBL. | No reference |
Activity (ADMET) | = 102 % | Effect on Oryza sativa (rice) plant growth in transplanted Oryza sativa field assessed as plant height at 30 g/ha treated after 10 days transplanting | ChEMBL. | No reference |
Activity (ADMET) | = 104 % | Effect on Oryza sativa (rice) plant growth in transplanted Oryza sativa field assessed as plant height at 30 g/ha treated after 7 days transplanting | ChEMBL. | No reference |
Activity (ADMET) | = 104 % | Effect on Oryza sativa (rice) plant growth in transplanted Oryza sativa field assessed as plant height at 30 g/ha treated after 3 days transplanting | ChEMBL. | No reference |
Activity (ADMET) | = 104 % | Effect on Oryza sativa (rice) plant growth in transplanted Oryza sativa field assessed as plant height at 20 g/ha treated after 3 days transplanting | ChEMBL. | No reference |
Activity (ADMET) | = 105 % | Effect on Oryza sativa (rice) plant growth in transplanted Oryza sativa field assessed as number of tillers at 30 g/ha treated after 15 days transplanting | ChEMBL. | No reference |
Activity (ADMET) | = 107 % | Effect on Oryza sativa (rice) plant growth in transplanted Oryza sativa field assessed as plant height at 20 g/ha treated after 7 days transplanting | ChEMBL. | No reference |
GI (ADMET) | < 5 % | Phytotoxicity against Oryza sativa (rice) assessed as growth inhibition under greenhouse at 5 g/ha measured after 18 days by preemergence activity assay | ChEMBL. | No reference |
Ki (binding) | = 32 nM | Inhibition of Saccharomyces cerevisiae acetohydroxyacid synthase by colorimetric assay | ChEMBL. | 23237384 |
MIC50 (functional) | = 41.7 uM | Antifungal activity against Saccharomyces cerevisiae after 72 hrs by broth microdilution assay | ChEMBL. | 23237384 |
MIC50 (functional) | = 62 uM | Antifungal activity against Candida albicans after 72 hrs by broth microdilution method | ChEMBL. | 23237384 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.