Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.0713 | 0.5 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0039 | 0 | 0.5 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.015 | 0.3723 | 0.7675 |
Brugia malayi | hypothetical protein | 0.0162 | 0.4147 | 0.8548 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.0713 | 0.0713 |
Brugia malayi | CAAX amino terminal protease family protein | 0.0183 | 0.4851 | 1 |
Leishmania major | CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) | 0.0183 | 0.4851 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.0713 | 0.147 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.0713 | 0.5 |
Trichomonas vaginalis | Clan U, family U48, CaaX prenyl peptidase 2-like | 0.0183 | 0.4851 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0336 | 0.0692 |
Schistosoma mansoni | lipoxygenase | 0.0172 | 0.448 | 0.9235 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0049 | 0.0336 | 0.0692 |
Trypanosoma brucei | CAAX amino terminal protease, putative | 0.0183 | 0.4851 | 0.5 |
Onchocerca volvulus | 0.0049 | 0.0336 | 1 | |
Schistosoma mansoni | family U48 unassigned peptidase (U48 family) | 0.0183 | 0.4851 | 1 |
Giardia lamblia | Hypothetical protein | 0.0183 | 0.4851 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.4851 | 1 |
Trypanosoma cruzi | peptidase with unknown catalytic mechanism (family U48) | 0.0183 | 0.4851 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.0713 | 0.0713 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0039 | 0 | 0.5 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0172 | 0.448 | 0.448 |
Echinococcus multilocularis | CAAX prenyl protease 2 | 0.0183 | 0.4851 | 0.4851 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0172 | 0.448 | 0.448 |
Echinococcus granulosus | CAAX prenyl protease 2 | 0.0183 | 0.4851 | 0.4851 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.4147 | 0.8548 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0048 | 0.0313 | 0.0645 |
Trypanosoma cruzi | CAAX prenyl protease 2, putative | 0.0183 | 0.4851 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.0713 | 0.5 |
Brugia malayi | PAS domain containing protein | 0.0048 | 0.0309 | 0.0636 |
Entamoeba histolytica | CAAX prenyl protease family | 0.0183 | 0.4851 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0102 | 0.2102 | 0.4333 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.0713 | 0.147 |
Brugia malayi | hypoxia-induced factor 1 | 0.015 | 0.3723 | 0.7675 |
Schistosoma mansoni | single-minded | 0.0048 | 0.0309 | 0.0636 |
Schistosoma mansoni | family U48 unassigned peptidase (U48 family) | 0.0183 | 0.4851 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.006 | 0.0713 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0048 | 0.0313 | 0.0645 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.006 | 0.0713 | 0.5 |
Echinococcus multilocularis | tumor protein p63 | 0.0336 | 1 | 1 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0048 | 0.0309 | 0.0636 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 40 uM | Displacement of FITC-AHx-KALETLRRVGDGVQRNHETAF-NH2 from human MCl1 (172 to 327) expressed in Escherichia coli BL21 (DE3) after 1 hr by fluorescence polarization anisotropy assay | ChEMBL. | 23244564 |
Ki (binding) | = 230 uM | Displacement of FITC-AHx-GQVGRQLAIIGDDINR-NH2 from Bcl-xL (unknown origin) after 1 hr by fluorescence polarization anisotropy assay | ChEMBL. | 23244564 |
Ki (binding) | > 1000 uM | Displacement of FITC-AHx-GQVGRQLAIIGDDINR-NH2 from Bcl2 (unknown origin) after 1 hr by fluorescence polarization anisotropy assay | ChEMBL. | 23244564 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.