TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 365.225 | Formula: C15H17BrN4O2
H donors: 3 H acceptors: 2 LogP: 2.98 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Brc1ccc(c(c1)/C=N/NC(=O)C1=NNC2C1CCCC2)O
InChi: 1S/C15H17BrN4O2/c16-10-5-6-13(21)9(7-10)8-17-20-15(22)14-11-3-1-2-4-12(11)18-19-14/h5-8,11-12,18,21H,1-4H2,(H,20,22)/b17-8+
InChiKey: OCNRTFYLYOPTGR-CAOOACKPSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Human immunodeficiency virus 1	Integrase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma congolense	RNA helicase, putative	Get druggable targets OG5_139608	All targets in OG5_139608
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_139608	All targets in OG5_139608
Trypanosoma brucei	RNA helicase, putative	Get druggable targets OG5_139608	All targets in OG5_139608
Plasmodium yoelii	integrase-related	Get druggable targets OG5_139608	All targets in OG5_139608

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.1333	0.3298	0.3298
Trichomonas vaginalis	TK family protein kinase	0.0894	0	0.5
Brugia malayi	protein-tyrosine kinase	0.2227	1	1
Schistosoma mansoni	adapter molecule crk	0.1333	0.3298	0.3298
Brugia malayi	Protein kinase domain containing protein	0.2227	1	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0894	0	0.5
Echinococcus multilocularis	tensin	0.1333	0.3298	0.3298
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.1333	0.3298	0.3298
Onchocerca volvulus		0.2227	1	1
Onchocerca volvulus		0.1333	0.3298	0.3298
Echinococcus multilocularis	signal transduction protein lnk realted	0.1333	0.3298	0.3298
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.1333	0.3298	0.3298
Loa Loa (eye worm)	STAT protein	0.1333	0.3298	0.3298
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.2227	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Schistosoma mansoni	GTPase activating protein	0.1333	0.3298	0.3298
Loa Loa (eye worm)	TK/FER protein kinase	0.2227	1	1
Echinococcus granulosus	expressed conserved protein	0.1333	0.3298	0.3298
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0894	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Echinococcus granulosus	SH2 motif	0.1333	0.3298	0.3298
Onchocerca volvulus		0.1333	0.3298	0.3298
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0894	0	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0894	0	0.5
Echinococcus multilocularis		0.1333	0.3298	0.3298
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Blk	0.2227	1	1
Echinococcus multilocularis	SH2 motif	0.1333	0.3298	0.3298
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Onchocerca volvulus		0.1333	0.3298	0.3298
Brugia malayi	hypothetical protein	0.2227	1	1
Brugia malayi	Tensin	0.1333	0.3298	0.3298
Schistosoma mansoni	tensin	0.1333	0.3298	0.3298
Schistosoma mansoni	nck2/grb4	0.1333	0.3298	0.3298
Loa Loa (eye worm)	hypothetical protein	0.1333	0.3298	0.3298
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Echinococcus granulosus	tyrosine kinase	0.2227	1	1
Echinococcus multilocularis	c src tyrosine kinase	0.2227	1	1
Echinococcus multilocularis	SH2 motif	0.1333	0.3298	0.3298
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.1333	0.3298	0.3298
Toxoplasma gondii	protein kinase domain-containing protein	0.0894	0	0.5
Entamoeba histolytica	SH2 domain containing protein	0.1333	0.3298	0.3298
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Echinococcus granulosus	tyrosine protein kinase ABL1	0.2227	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.1333	0.3298	0.3298
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.2227	1	1
Echinococcus multilocularis	SH2 domain containing protein 7	0.1333	0.3298	0.3298
Echinococcus granulosus	tyrosine kinase	0.2227	1	1
Brugia malayi	SH2 domain containing protein	0.2227	1	1
Trichomonas vaginalis	CAMK family protein kinase	0.0894	0	0.5
Schistosoma mansoni	tensin	0.1333	0.3298	0.3298
Schistosoma mansoni	SH2A	0.1333	0.3298	0.3298
Echinococcus granulosus	tyrosine protein kinase Src42A	0.1333	0.3298	0.3298
Loa Loa (eye worm)	hypothetical protein	0.1333	0.3298	0.3298
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.1333	0.3298	0.3298
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.1333	0.3298	0.3298
Brugia malayi	SH2 domain containing protein	0.1333	0.3298	0.3298
Echinococcus multilocularis	tyrosine protein kinase Srms	0.2227	1	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.2227	1	1
Echinococcus multilocularis	NCK adaptor protein	0.1333	0.3298	0.3298
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.1333	0.3298	0.3298
Loa Loa (eye worm)	TK/FER protein kinase	0.2227	1	1
Echinococcus multilocularis	tyrosine kinase	0.2227	1	1
Onchocerca volvulus		0.1333	0.3298	0.3298
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.2227	1	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.1333	0.3298	0.3298
Brugia malayi	SH2 domain containing protein	0.1333	0.3298	0.3298
Schistosoma mansoni	signal transduction protein lnk-related	0.1333	0.3298	0.3298
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0894	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0894	0	0.5
Schistosoma mansoni	tyrosine kinase	0.2227	1	1
Brugia malayi	Tyrosine-protein kinase abl-1	0.2227	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Schistosoma mansoni	tensin-related	0.1333	0.3298	0.3298
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.1333	0.3298	0.3298
Onchocerca volvulus		0.2227	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Brugia malayi	SH2 domain containing protein	0.1333	0.3298	0.3298
Trichomonas vaginalis	protein kinase atn1, putative	0.0894	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.1333	0.3298	0.3298
Trypanosoma cruzi	protein kinase, putative	0.0894	0	0.5
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.1333	0.3298	0.3298
Schistosoma mansoni	tyrosine kinase	0.2227	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.1333	0.3298	0.3298
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.1333	0.3298	0.3298
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0894	0	0.5
Plasmodium vivax	protein kinase, putative	0.0894	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.2227	1	1
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0894	0	0.5
Giardia lamblia	Kinase, NEK	0.0894	0	0.5
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.2227	1	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0894	0	0.5
Echinococcus granulosus	tyrosine protein kinase Src64B	0.2227	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Brugia malayi	Variant SH3 domain containing protein	0.1333	0.3298	0.3298
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0894	0	0.5
Onchocerca volvulus		0.1333	0.3298	0.3298
Echinococcus multilocularis	tyrosine protein kinase shark	0.2227	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0894	0	0.5
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.1333	0.3298	0.3298
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.2227	1	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0894	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Loa Loa (eye worm)	TK/ABL protein kinase	0.2227	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.2227	1	1
Brugia malayi	Variant SH3 domain containing protein	0.1333	0.3298	0.3298
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Leishmania major	hypothetical protein, conserved	0.0894	0	0.5
Loa Loa (eye worm)	SH2 domain-containing protein	0.1333	0.3298	0.3298
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.2227	1	1
Onchocerca volvulus		0.1333	0.3298	0.3298
Schistosoma mansoni	growth factor receptor-bound protein	0.1333	0.3298	0.3298
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.2227	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.2227	1	1
Loa Loa (eye worm)	hypothetical protein	0.1333	0.3298	0.3298
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Leishmania major	protein kinase, putative	0.0894	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.2227	1	1
Echinococcus granulosus	signal transduction protein lnk realted	0.1333	0.3298	0.3298
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.1333	0.3298	0.3298
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.2227	1	1
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.1333	0.3298	0.3298
Loa Loa (eye worm)	hypothetical protein	0.1333	0.3298	0.3298
Loa Loa (eye worm)	hypothetical protein	0.1333	0.3298	0.3298
Echinococcus granulosus	c src tyrosine kinase	0.2227	1	1
Leishmania major	protein kinase, putative	0.0894	0	0.5
Schistosoma mansoni	suppressor of cytokine signaling	0.1333	0.3298	0.3298
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.1333	0.3298	0.3298
Schistosoma mansoni	shc transforming protein	0.1333	0.3298	0.3298
Schistosoma mansoni	tensin-related	0.1333	0.3298	0.3298
Echinococcus multilocularis	tyrosine protein kinase Abl	0.2227	1	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2227	1	1
Echinococcus granulosus	SH2 motif	0.1333	0.3298	0.3298
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Schistosoma mansoni	hypothetical protein	0.1333	0.3298	0.3298
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.1333	0.3298	0.3298
Loa Loa (eye worm)	TK/FER protein kinase	0.2227	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2227	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Echinococcus multilocularis	growth factor receptor bound protein 2	0.1333	0.3298	0.3298
Echinococcus granulosus	tyrosine protein kinase shark	0.2227	1	1
Schistosoma mansoni	tensin	0.1333	0.3298	0.3298
Loa Loa (eye worm)	hypothetical protein	0.1333	0.3298	0.3298
Loa Loa (eye worm)	hypothetical protein	0.1333	0.3298	0.3298
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.1333	0.3298	0.3298
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0894	0	0.5
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.1333	0.3298	0.3298
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.2227	1	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.2227	1	1
Schistosoma mansoni	vav2	0.1333	0.3298	0.3298
Brugia malayi	SRC-1	0.2227	1	1
Brugia malayi	cytokine inducible SH2-containing protein 5	0.1333	0.3298	0.3298
Brugia malayi	tRNA modification GTPase TrmE family protein	0.1333	0.3298	0.3298
Echinococcus granulosus	SH2 domain containing adapter protein F	0.1333	0.3298	0.3298
Trichomonas vaginalis	AGC family protein kinase	0.0894	0	0.5
Loa Loa (eye worm)	SRC-1	0.2227	1	1
Schistosoma mansoni	growth factor receptor-bound protein	0.1333	0.3298	0.3298
Onchocerca volvulus		0.2227	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Brugia malayi	hypothetical protein	0.1333	0.3298	0.3298
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Brugia malayi	SH2 domain containing protein	0.2227	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.2227	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Toxoplasma gondii	STE kinase	0.0894	0	0.5
Schistosoma mansoni	hypothetical protein	0.1333	0.3298	0.3298
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.2227	1	1
Loa Loa (eye worm)	hypothetical protein	0.2227	1	1
Echinococcus granulosus	tyrosine protein kinase Srms	0.2227	1	1
Loa Loa (eye worm)	hypothetical protein	0.1333	0.3298	0.3298
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Echinococcus granulosus	suppressor of cytokine signaling 6	0.1333	0.3298	0.3298
Loa Loa (eye worm)	TK protein kinase	0.2227	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Echinococcus multilocularis	tensin	0.1333	0.3298	0.3298
Trichomonas vaginalis	conserved hypothetical protein	0.0894	0	0.5
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.1333	0.3298	0.3298
Brugia malayi	SH2 domain containing protein	0.1333	0.3298	0.3298
Echinococcus granulosus	SHC transforming protein 3	0.1333	0.3298	0.3298
Trypanosoma cruzi	protein kinase, putative	0.0894	0	0.5
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.2227	1	1
Plasmodium falciparum	protein kinase, putative	0.0894	0	0.5
Echinococcus granulosus	tyrosine protein kinase Src42A	0.2227	1	1
Echinococcus multilocularis	SH2 motif	0.1333	0.3298	0.3298
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.1333	0.3298	0.3298
Loa Loa (eye worm)	TK/FER protein kinase	0.2227	1	1
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.2227	1	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0894	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.1333	0.3298	0.3298
Echinococcus multilocularis	SHC transforming protein 3	0.1333	0.3298	0.3298
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Schistosoma mansoni	tyrosine kinase	0.2227	1	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.2227	1	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.1333	0.3298	0.3298
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Schistosoma mansoni	tyrosine kinase	0.2227	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Trypanosoma brucei	protein kinase, putative	0.0894	0	0.5
Brugia malayi	RhoGAP domain containing protein	0.1333	0.3298	0.3298
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.1333	0.3298	0.3298
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Echinococcus granulosus	tensin	0.1333	0.3298	0.3298
Trypanosoma brucei	Pseudokinase, putative	0.0894	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2227	1	1
Echinococcus granulosus	hypothetical protein	0.1333	0.3298	0.3298
Trichomonas vaginalis	conserved hypothetical protein	0.0894	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.1333	0.3298	0.3298
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.1333	0.3298	0.3298
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.1333	0.3298	0.3298
Brugia malayi	Protein kinase domain containing protein	0.2227	1	1
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0894	0	0.5
Brugia malayi	SH2 domain containing protein	0.1333	0.3298	0.3298
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.1333	0.3298	0.3298
Echinococcus granulosus	tyrosine protein kinase Lyn	0.2227	1	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.1333	0.3298	0.3298
Loa Loa (eye worm)	SH2 domain-containing protein	0.1333	0.3298	0.3298
Brugia malayi	Variant SH3 domain containing protein	0.1333	0.3298	0.3298
Loa Loa (eye worm)	hypothetical protein	0.1333	0.3298	0.3298
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2227	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0894	0	0.5
Echinococcus granulosus	NCK adaptor protein	0.1333	0.3298	0.3298
Echinococcus granulosus	N chimaerin	0.1333	0.3298	0.3298
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.2227	1	1
Echinococcus multilocularis	N chimaerin	0.1333	0.3298	0.3298
Loa Loa (eye worm)	hypothetical protein	0.1333	0.3298	0.3298
Schistosoma mansoni	tyrosine kinase	0.2227	1	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.1333	0.3298	0.3298
Echinococcus granulosus	growth factor receptor bound protein 2	0.1333	0.3298	0.3298
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.1333	0.3298	0.3298
Trichomonas vaginalis	conserved hypothetical protein	0.0894	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0894	0	0.5
Echinococcus granulosus	SH2 domain containing protein 7	0.1333	0.3298	0.3298
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.2227	1	1
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0894	0	0.5
Giardia lamblia	Kinase	0.0894	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0894	0	0.5
Brugia malayi	Sex muscle abnormal protein 5	0.1333	0.3298	0.3298
Giardia lamblia	Protein 21.1	0.0894	0	0.5
Plasmodium falciparum	protein kinase, putative	0.0894	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.2227	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.2227	1	1
Brugia malayi	SH2 domain containing protein	0.1333	0.3298	0.3298
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.2227	1	1
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.2227	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.2227	1	1
Trichomonas vaginalis	STE family protein kinase	0.0894	0	0.5
Echinococcus granulosus	suppressor of cytokine signaling 7	0.1333	0.3298	0.3298
Toxoplasma gondii	protein kinase	0.0894	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.1333	0.3298	0.3298
Onchocerca volvulus		0.2227	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0894	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Onchocerca volvulus		0.2227	1	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0894	0	0.5
Onchocerca volvulus		0.2227	1	1
Plasmodium falciparum	protein kinase, putative	0.0894	0	0.5
Brugia malayi	SH2 domain containing protein	0.1333	0.3298	0.3298
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Schistosoma mansoni	suppressor of cytokine signaling	0.1333	0.3298	0.3298
Brugia malayi	STAT protein, DNA binding domain containing protein	0.1333	0.3298	0.3298
Brugia malayi	Variant SH3 domain containing protein	0.1333	0.3298	0.3298
Entamoeba histolytica	protein kinase, putative	0.1333	0.3298	0.3298
Schistosoma mansoni	tyrosine kinase	0.2227	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Echinococcus granulosus	tyrosine protein kinase Blk	0.2227	1	1
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.1333	0.3298	0.3298
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0894	0	0.5
Giardia lamblia	Kinase, NEK	0.0894	0	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (ADMET)	= 5 uM	Cytotoxicity against human HCT116 p53 +/+ and -/- cells after 72 hrs by MTT assay	ChEMBL.	23306052
IC50 (binding)	= 15 uM	Inhibition of wild type HIV1 integrase strand transfer activity using 5'-end 32P-labeled linear oligonucleotide as substrate preincubated for 30 mins	ChEMBL.	23306052
IC50 (binding)	= 29 uM	Inhibition of wild type HIV1 integrase 3'-processing activity using 5'-end 32P-labeled linear oligonucleotide as substrate preincubated for 30 mins	ChEMBL.	23306052

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	23306052

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2311873

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1740196