TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 531.709 | Formula: C31H37N3O3S
H donors: 1 H acceptors: 2 LogP: 6.37 Rotable bonds: 8
Rule of 5 violations (Lipinski): 2
SMILES: O=C(N1CCC2(CC1)CCN(c1c(O2)cccc1)CNC(=O)c1cccs1)Cc1ccc(cc1)C(C)(C)C
InChi: 1S/C31H37N3O3S/c1-30(2,3)24-12-10-23(11-13-24)21-28(35)33-17-14-31(15-18-33)16-19-34(25-7-4-5-8-26(25)37-31)22-32-29(36)27-9-6-20-38-27/h4-13,20H,14-19,21-22H2,1-3H3,(H,32,36)
InChiKey: TWXNFFAXKPKJHR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Acyl-CoA desaturase 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium berghei	stearoyl-CoA desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma brucei	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Plasmodium falciparum	stearoyl-CoA desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania infantum	fatty-acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania donovani	stearic acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Candida albicans	one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9-fatty acid desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Brugia malayi	acyl-CoA desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Plasmodium yoelii	delta-9 fatty acid desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma brucei gambiense	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania major	fatty-acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania mexicana	stearic acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma cruzi	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Candida albicans	one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9-fatty acid desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Onchocerca volvulus		Get druggable targets OG5_126939	All targets in OG5_126939
Loa Loa (eye worm)	acyl-CoA desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania braziliensis	fatty-acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Neospora caninum	fatty acyl-CoA desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma cruzi	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania donovani	fatty-acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Plasmodium vivax	stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative	Get druggable targets OG5_126939	All targets in OG5_126939
Plasmodium knowlesi	stearoyl-CoA desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania mexicana	fatty-acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Onchocerca volvulus		Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma cruzi	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania major	stearic acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania braziliensis	stearic acid desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania infantum	stearic acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma congolense	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Candida albicans	one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9 fatty acid desaturase	Acyl-CoA desaturase 1	358 aa	317 aa	27.1 %
Candida albicans	one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9 fatty acid desaturase	Acyl-CoA desaturase 1	358 aa	317 aa	27.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	signal transduction protein lnk-related	0.0181	0.3334	0.3334
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0181	0.3334	0.3334
Brugia malayi	SH2 domain containing protein	0.0181	0.3334	0.3334
Loa Loa (eye worm)	TK/FER protein kinase	0.0302	1	1
Echinococcus multilocularis	tyrosine kinase	0.0302	1	1
Onchocerca volvulus		0.0181	0.3334	0.3334
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0302	1	1
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0181	0.3334	0.3334
Brugia malayi	SH2 domain containing protein	0.0181	0.3334	0.3334
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0302	1	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0302	1	1
Echinococcus multilocularis	NCK adaptor protein	0.0181	0.3334	0.3334
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0181	0.3334	0.3334
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0181	0.3334	0.3334
Loa Loa (eye worm)	hypothetical protein	0.0181	0.3334	0.3334
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0181	0.3334	0.3334
Echinococcus granulosus	tyrosine kinase	0.0302	1	1
Trichomonas vaginalis	CAMK family protein kinase	0.0121	0	0.5
Brugia malayi	SH2 domain containing protein	0.0302	1	1
Schistosoma mansoni	tensin	0.0181	0.3334	0.3334
Schistosoma mansoni	SH2A	0.0181	0.3334	0.3334
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0302	1	1
Echinococcus multilocularis	SH2 domain containing protein 7	0.0181	0.3334	0.3334
Toxoplasma gondii	protein kinase domain-containing protein	0.0121	0	0.5
Entamoeba histolytica	SH2 domain containing protein	0.0181	0.3334	0.3334
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0302	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0181	0.3334	0.3334
Echinococcus granulosus	tyrosine kinase	0.0302	1	1
Echinococcus multilocularis	c src tyrosine kinase	0.0302	1	1
Echinococcus multilocularis	SH2 motif	0.0181	0.3334	0.3334
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0181	0.3334	0.3334
Schistosoma mansoni	tensin	0.0181	0.3334	0.3334
Schistosoma mansoni	nck2/grb4	0.0181	0.3334	0.3334
Loa Loa (eye worm)	hypothetical protein	0.0181	0.3334	0.3334
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Onchocerca volvulus		0.0181	0.3334	0.3334
Brugia malayi	hypothetical protein	0.0302	1	1
Brugia malayi	Tensin	0.0181	0.3334	0.3334
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Echinococcus multilocularis		0.0181	0.3334	0.3334
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0302	1	1
Echinococcus multilocularis	SH2 motif	0.0181	0.3334	0.3334
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0121	0	0.5
Echinococcus granulosus	SH2 motif	0.0181	0.3334	0.3334
Onchocerca volvulus		0.0181	0.3334	0.3334
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0121	0	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0121	0	0.5
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0181	0.3334	0.3334
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0181	0.3334	0.3334
Echinococcus multilocularis	signal transduction protein lnk realted	0.0181	0.3334	0.3334
Loa Loa (eye worm)	STAT protein	0.0181	0.3334	0.3334
Onchocerca volvulus		0.0181	0.3334	0.3334
Onchocerca volvulus		0.0302	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0302	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Schistosoma mansoni	GTPase activating protein	0.0181	0.3334	0.3334
Loa Loa (eye worm)	TK/FER protein kinase	0.0302	1	1
Echinococcus granulosus	expressed conserved protein	0.0181	0.3334	0.3334
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0181	0.3334	0.3334
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Schistosoma mansoni	adapter molecule crk	0.0181	0.3334	0.3334
Trichomonas vaginalis	TK family protein kinase	0.0121	0	0.5
Brugia malayi	protein-tyrosine kinase	0.0302	1	1
Brugia malayi	Protein kinase domain containing protein	0.0302	1	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0121	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Echinococcus multilocularis	tensin	0.0181	0.3334	0.3334
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0302	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0181	0.3334	0.3334
Echinococcus granulosus	tyrosine protein kinase shark	0.0302	1	1
Echinococcus granulosus	SH2 motif	0.0181	0.3334	0.3334
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Schistosoma mansoni	hypothetical protein	0.0181	0.3334	0.3334
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0181	0.3334	0.3334
Loa Loa (eye worm)	TK/FER protein kinase	0.0302	1	1
Schistosoma mansoni	tensin-related	0.0181	0.3334	0.3334
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0302	1	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0302	1	1
Schistosoma mansoni	suppressor of cytokine signaling	0.0181	0.3334	0.3334
Leishmania major	protein kinase, putative	0.0121	0	0.5
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0181	0.3334	0.3334
Schistosoma mansoni	shc transforming protein	0.0181	0.3334	0.3334
Echinococcus granulosus	signal transduction protein lnk realted	0.0181	0.3334	0.3334
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0181	0.3334	0.3334
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0302	1	1
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0181	0.3334	0.3334
Loa Loa (eye worm)	hypothetical protein	0.0181	0.3334	0.3334
Loa Loa (eye worm)	hypothetical protein	0.0181	0.3334	0.3334
Echinococcus granulosus	c src tyrosine kinase	0.0302	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0302	1	1
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0302	1	1
Loa Loa (eye worm)	hypothetical protein	0.0181	0.3334	0.3334
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Leishmania major	protein kinase, putative	0.0121	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0302	1	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0302	1	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.0181	0.3334	0.3334
Onchocerca volvulus		0.0181	0.3334	0.3334
Schistosoma mansoni	growth factor receptor-bound protein	0.0181	0.3334	0.3334
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0302	1	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0121	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Loa Loa (eye worm)	TK/ABL protein kinase	0.0302	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0302	1	1
Brugia malayi	Variant SH3 domain containing protein	0.0181	0.3334	0.3334
Leishmania major	hypothetical protein, conserved	0.0121	0	0.5
Onchocerca volvulus		0.0181	0.3334	0.3334
Echinococcus multilocularis	tyrosine protein kinase shark	0.0302	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0121	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0181	0.3334	0.3334
Plasmodium falciparum	tyrosine kinase-like protein	0.0121	0	0.5
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0302	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0181	0.3334	0.3334
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0121	0	0.5
Giardia lamblia	Kinase, NEK	0.0121	0	0.5
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0302	1	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0181	0.3334	0.3334
Loa Loa (eye worm)	hypothetical protein	0.0181	0.3334	0.3334
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0121	0	0.5
Plasmodium vivax	protein kinase, putative	0.0121	0	0.5
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0121	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0302	1	1
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0181	0.3334	0.3334
Schistosoma mansoni	tyrosine kinase	0.0302	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Onchocerca volvulus		0.0302	1	1
Brugia malayi	SH2 domain containing protein	0.0181	0.3334	0.3334
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Trichomonas vaginalis	protein kinase atn1, putative	0.0121	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0181	0.3334	0.3334
Trypanosoma cruzi	protein kinase, putative	0.0121	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Brugia malayi	Tyrosine-protein kinase abl-1	0.0302	1	1
Schistosoma mansoni	tensin-related	0.0181	0.3334	0.3334
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0181	0.3334	0.3334
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0121	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0121	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0302	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0181	0.3334	0.3334
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0181	0.3334	0.3334
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0181	0.3334	0.3334
Trichomonas vaginalis	conserved hypothetical protein	0.0121	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0302	1	1
Echinococcus granulosus	hypothetical protein	0.0181	0.3334	0.3334
Trypanosoma brucei	protein kinase, putative	0.0121	0	0.5
Brugia malayi	RhoGAP domain containing protein	0.0181	0.3334	0.3334
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0181	0.3334	0.3334
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Echinococcus granulosus	tensin	0.0181	0.3334	0.3334
Trypanosoma brucei	Pseudokinase, putative	0.0121	0	0.5
Echinococcus multilocularis	SHC transforming protein 3	0.0181	0.3334	0.3334
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0302	1	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0302	1	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0181	0.3334	0.3334
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0302	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0121	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0181	0.3334	0.3334
Plasmodium falciparum	protein kinase, putative	0.0121	0	0.5
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0302	1	1
Echinococcus multilocularis	SH2 motif	0.0181	0.3334	0.3334
Loa Loa (eye worm)	TK/FER protein kinase	0.0302	1	1
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0181	0.3334	0.3334
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0302	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0121	0	0.5
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0181	0.3334	0.3334
Trypanosoma cruzi	protein kinase, putative	0.0121	0	0.5
Brugia malayi	SH2 domain containing protein	0.0181	0.3334	0.3334
Echinococcus granulosus	SHC transforming protein 3	0.0181	0.3334	0.3334
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0302	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0181	0.3334	0.3334
Loa Loa (eye worm)	TK protein kinase	0.0302	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Echinococcus multilocularis	tensin	0.0181	0.3334	0.3334
Loa Loa (eye worm)	hypothetical protein	0.0302	1	1
Echinococcus granulosus	tyrosine protein kinase Srms	0.0302	1	1
Loa Loa (eye worm)	hypothetical protein	0.0181	0.3334	0.3334
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0302	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0302	1	1
Toxoplasma gondii	STE kinase	0.0121	0	0.5
Schistosoma mansoni	hypothetical protein	0.0181	0.3334	0.3334
Schistosoma mansoni	growth factor receptor-bound protein	0.0181	0.3334	0.3334
Onchocerca volvulus		0.0302	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Brugia malayi	hypothetical protein	0.0181	0.3334	0.3334
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Brugia malayi	SH2 domain containing protein	0.0302	1	1
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0181	0.3334	0.3334
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0181	0.3334	0.3334
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0181	0.3334	0.3334
Trichomonas vaginalis	AGC family protein kinase	0.0121	0	0.5
Loa Loa (eye worm)	SRC-1	0.0302	1	1
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0181	0.3334	0.3334
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0302	1	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0302	1	1
Schistosoma mansoni	vav2	0.0181	0.3334	0.3334
Brugia malayi	SRC-1	0.0302	1	1
Schistosoma mansoni	tensin	0.0181	0.3334	0.3334
Loa Loa (eye worm)	hypothetical protein	0.0181	0.3334	0.3334
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0181	0.3334	0.3334
Loa Loa (eye worm)	hypothetical protein	0.0181	0.3334	0.3334
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0121	0	0.5
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0181	0.3334	0.3334
Giardia lamblia	Kinase, NEK	0.0121	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Echinococcus granulosus	tyrosine protein kinase Blk	0.0302	1	1
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0181	0.3334	0.3334
Brugia malayi	Variant SH3 domain containing protein	0.0181	0.3334	0.3334
Entamoeba histolytica	protein kinase, putative	0.0181	0.3334	0.3334
Schistosoma mansoni	tyrosine kinase	0.0302	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Schistosoma mansoni	suppressor of cytokine signaling	0.0181	0.3334	0.3334
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0121	0	0.5
Onchocerca volvulus		0.0302	1	1
Plasmodium falciparum	protein kinase, putative	0.0121	0	0.5
Brugia malayi	SH2 domain containing protein	0.0181	0.3334	0.3334
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0121	0	0.5
Onchocerca volvulus		0.0302	1	1
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0181	0.3334	0.3334
Toxoplasma gondii	protein kinase	0.0121	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0181	0.3334	0.3334
Onchocerca volvulus		0.0302	1	1
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0302	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0302	1	1
Brugia malayi	SH2 domain containing protein	0.0181	0.3334	0.3334
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0302	1	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0302	1	1
Trichomonas vaginalis	STE family protein kinase	0.0121	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0302	1	1
Giardia lamblia	Kinase	0.0121	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0121	0	0.5
Brugia malayi	Sex muscle abnormal protein 5	0.0181	0.3334	0.3334
Giardia lamblia	Protein 21.1	0.0121	0	0.5
Plasmodium falciparum	protein kinase, putative	0.0121	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0181	0.3334	0.3334
Echinococcus granulosus	SH2 domain containing protein 7	0.0181	0.3334	0.3334
Trichomonas vaginalis	conserved hypothetical protein	0.0121	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0121	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0302	1	1
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0121	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0302	1	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0181	0.3334	0.3334
Echinococcus granulosus	growth factor receptor bound protein 2	0.0181	0.3334	0.3334
Echinococcus multilocularis	N chimaerin	0.0181	0.3334	0.3334
Loa Loa (eye worm)	hypothetical protein	0.0181	0.3334	0.3334
Echinococcus granulosus	N chimaerin	0.0181	0.3334	0.3334
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0302	1	1
Loa Loa (eye worm)	hypothetical protein	0.0181	0.3334	0.3334
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0302	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0121	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0121	0	0.5
Echinococcus granulosus	NCK adaptor protein	0.0181	0.3334	0.3334
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0181	0.3334	0.3334
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0302	1	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.0181	0.3334	0.3334
Loa Loa (eye worm)	SH2 domain-containing protein	0.0181	0.3334	0.3334
Brugia malayi	Variant SH3 domain containing protein	0.0181	0.3334	0.3334
Brugia malayi	Protein kinase domain containing protein	0.0302	1	1
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0121	0	0.5
Brugia malayi	SH2 domain containing protein	0.0181	0.3334	0.3334

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.14 uM	Inhibition of rat SCD1 by rat microsomal assay	ChEMBL.	23265904

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2315488

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1740403