Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0044 | 0.0841 | 1 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0034 | 0.0633 | 0.5 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0044 | 0.0841 | 0.0134 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0145 | 0.2985 | 0.2443 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0044 | 0.0841 | 1 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0034 | 0.0633 | 0.5 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.004 | 0.0764 | 0.5 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.004 | 0.0764 | 0.5 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0149 | 0.3073 | 0.2538 |
Onchocerca volvulus | 0.0178 | 0.369 | 0.5 | |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0149 | 0.3073 | 1 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.0717 | 0.5 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0475 | 1 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0044 | 0.0841 | 1 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0475 | 1 | 1 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0038 | 0.0717 | 0.5 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.0717 | 0.5 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.0717 | 0.5 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0475 | 1 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.0717 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0038 | 0.0717 | 0.5 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0149 | 0.3073 | 1 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.004 | 0.0764 | 1 |
Loa Loa (eye worm) | acetyltransferase | 0.0149 | 0.3073 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0038 | 0.0717 | 0.8525 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0038 | 0.0717 | 0.8525 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0044 | 0.0841 | 1 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0044 | 0.0841 | 0.5 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0038 | 0.0717 | 0.8525 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 1.6 uM | Antitubercular activity against Mycobacterium tuberculosis H37Rv ATCC27294 assessed as complete cessation of growth | ChEMBL. | 23211970 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.