TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 476.475 | Formula: C21H19F3N6O2S
H donors: 1 H acceptors: 5 LogP: 2.29 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1ccc(nn1)N1CCN(CC1)C(=O)c1ccccc1C(F)(F)F)NCc1nccs1
InChi: 1S/C21H19F3N6O2S/c22-21(23,24)15-4-2-1-3-14(15)20(32)30-10-8-29(9-11-30)17-6-5-16(27-28-17)19(31)26-13-18-25-7-12-33-18/h1-7,12H,8-11,13H2,(H,26,31)
InChiKey: NJJGBNUYIOHKAB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	stearoyl-CoA desaturase (delta-9-desaturase)	Starlite/ChEMBL	References
Mus musculus	stearoyl-Coenzyme A desaturase 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium vivax	stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative	Get druggable targets OG5_126939	All targets in OG5_126939
Plasmodium knowlesi	stearoyl-CoA desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania mexicana	fatty-acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Onchocerca volvulus		Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma cruzi	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania major	stearic acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania braziliensis	stearic acid desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania infantum	fatty-acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma congolense	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma brucei	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Plasmodium berghei	stearoyl-CoA desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Plasmodium falciparum	stearoyl-CoA desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania infantum	stearic acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania donovani	fatty-acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Brugia malayi	acyl-CoA desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Candida albicans	one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9-fatty acid desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Plasmodium yoelii	delta-9 fatty acid desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma brucei gambiense	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania mexicana	stearic acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania major	fatty-acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Candida albicans	one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9-fatty acid desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Onchocerca volvulus		Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma cruzi	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Loa Loa (eye worm)	acyl-CoA desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania braziliensis	fatty-acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma cruzi	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Neospora caninum	fatty acyl-CoA desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania donovani	stearic acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	SRC-1	0.078	1	1
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0463	0.3158	0.3158
Trichomonas vaginalis	AGC family protein kinase	0.0317	0	0.5
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0463	0.3158	0.3158
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0463	0.3158	0.3158
Brugia malayi	SH2 domain containing protein	0.078	1	1
Brugia malayi	hypothetical protein	0.0463	0.3158	0.3158
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Onchocerca volvulus		0.078	1	1
Schistosoma mansoni	growth factor receptor-bound protein	0.0463	0.3158	0.3158
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0317	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0463	0.3158	0.3158
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0463	0.3158	0.3158
Loa Loa (eye worm)	hypothetical protein	0.0463	0.3158	0.3158
Schistosoma mansoni	tensin	0.0463	0.3158	0.3158
Brugia malayi	SRC-1	0.078	1	1
Schistosoma mansoni	vav2	0.0463	0.3158	0.3158
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.078	1	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.078	1	1
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0463	0.3158	0.3158
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0463	0.3158	0.3158
Echinococcus granulosus	tyrosine protein kinase Srms	0.078	1	1
Loa Loa (eye worm)	hypothetical protein	0.078	1	1
Echinococcus multilocularis	tensin	0.0463	0.3158	0.3158
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Loa Loa (eye worm)	TK protein kinase	0.078	1	1
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0463	0.3158	0.3158
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Schistosoma mansoni	hypothetical protein	0.0463	0.3158	0.3158
Toxoplasma gondii	STE kinase	0.0317	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.078	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.078	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0463	0.3158	0.3158
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0317	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Schistosoma mansoni	tyrosine kinase	0.078	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0463	0.3158	0.3158
Echinococcus granulosus	tyrosine protein kinase Fyn	0.078	1	1
Schistosoma mansoni	tyrosine kinase	0.078	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Echinococcus multilocularis	SHC transforming protein 3	0.0463	0.3158	0.3158
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.078	1	1
Echinococcus granulosus	SHC transforming protein 3	0.0463	0.3158	0.3158
Brugia malayi	SH2 domain containing protein	0.0463	0.3158	0.3158
Trypanosoma cruzi	protein kinase, putative	0.0317	0	0.5
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0463	0.3158	0.3158
Trichomonas vaginalis	conserved hypothetical protein	0.0317	0	0.5
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.078	1	1
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0463	0.3158	0.3158
Loa Loa (eye worm)	TK/FER protein kinase	0.078	1	1
Echinococcus multilocularis	SH2 motif	0.0463	0.3158	0.3158
Plasmodium falciparum	protein kinase, putative	0.0317	0	0.5
Echinococcus granulosus	tyrosine protein kinase Src42A	0.078	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0317	0	0.5
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0463	0.3158	0.3158
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0463	0.3158	0.3158
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0463	0.3158	0.3158
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Trypanosoma brucei	Pseudokinase, putative	0.0317	0	0.5
Echinococcus granulosus	tensin	0.0463	0.3158	0.3158
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0463	0.3158	0.3158
Trypanosoma brucei	protein kinase, putative	0.0317	0	0.5
Brugia malayi	RhoGAP domain containing protein	0.0463	0.3158	0.3158
Echinococcus granulosus	hypothetical protein	0.0463	0.3158	0.3158
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.078	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Echinococcus granulosus	NCK adaptor protein	0.0463	0.3158	0.3158
Trichomonas vaginalis	conserved hypothetical protein	0.0317	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.078	1	1
Loa Loa (eye worm)	hypothetical protein	0.0463	0.3158	0.3158
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.078	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Echinococcus granulosus	N chimaerin	0.0463	0.3158	0.3158
Brugia malayi	SH2 domain containing protein	0.0463	0.3158	0.3158
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0317	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.078	1	1
Brugia malayi	Variant SH3 domain containing protein	0.0463	0.3158	0.3158
Loa Loa (eye worm)	SH2 domain-containing protein	0.0463	0.3158	0.3158
Echinococcus granulosus	tyrosine protein kinase Lyn	0.078	1	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.0463	0.3158	0.3158
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0463	0.3158	0.3158
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0317	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.078	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0317	0	0.5
Echinococcus granulosus	SH2 domain containing protein 7	0.0463	0.3158	0.3158
Trichomonas vaginalis	conserved hypothetical protein	0.0317	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0463	0.3158	0.3158
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Giardia lamblia	Protein 21.1	0.0317	0	0.5
Plasmodium falciparum	protein kinase, putative	0.0317	0	0.5
Brugia malayi	Sex muscle abnormal protein 5	0.0463	0.3158	0.3158
Trichomonas vaginalis	conserved hypothetical protein	0.0317	0	0.5
Giardia lamblia	Kinase	0.0317	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0463	0.3158	0.3158
Echinococcus multilocularis	N chimaerin	0.0463	0.3158	0.3158
Echinococcus granulosus	growth factor receptor bound protein 2	0.0463	0.3158	0.3158
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0463	0.3158	0.3158
Schistosoma mansoni	tyrosine kinase	0.078	1	1
Onchocerca volvulus		0.078	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0317	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Plasmodium falciparum	protein kinase, putative	0.0317	0	0.5
Brugia malayi	SH2 domain containing protein	0.0463	0.3158	0.3158
Onchocerca volvulus		0.078	1	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0317	0	0.5
Trichomonas vaginalis	STE family protein kinase	0.0317	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.078	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.078	1	1
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.078	1	1
Brugia malayi	SH2 domain containing protein	0.0463	0.3158	0.3158
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.078	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.078	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0463	0.3158	0.3158
Onchocerca volvulus		0.078	1	1
Toxoplasma gondii	protein kinase	0.0317	0	0.5
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0463	0.3158	0.3158
Echinococcus granulosus	tyrosine protein kinase Blk	0.078	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Giardia lamblia	Kinase, NEK	0.0317	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0463	0.3158	0.3158
Schistosoma mansoni	suppressor of cytokine signaling	0.0463	0.3158	0.3158
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0463	0.3158	0.3158
Schistosoma mansoni	tyrosine kinase	0.078	1	1
Brugia malayi	Variant SH3 domain containing protein	0.0463	0.3158	0.3158
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0463	0.3158	0.3158
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0317	0	0.5
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0317	0	0.5
Onchocerca volvulus		0.0463	0.3158	0.3158
Echinococcus granulosus	SH2 motif	0.0463	0.3158	0.3158
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0317	0	0.5
Echinococcus multilocularis	SH2 motif	0.0463	0.3158	0.3158
Echinococcus multilocularis	tyrosine protein kinase Blk	0.078	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Echinococcus multilocularis		0.0463	0.3158	0.3158
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Echinococcus multilocularis	tensin	0.0463	0.3158	0.3158
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0317	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.078	1	1
Schistosoma mansoni	adapter molecule crk	0.0463	0.3158	0.3158
Trichomonas vaginalis	TK family protein kinase	0.0317	0	0.5
Brugia malayi	protein-tyrosine kinase	0.078	1	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0463	0.3158	0.3158
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Echinococcus granulosus	expressed conserved protein	0.0463	0.3158	0.3158
Loa Loa (eye worm)	TK/FER protein kinase	0.078	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.078	1	1
Schistosoma mansoni	GTPase activating protein	0.0463	0.3158	0.3158
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Echinococcus multilocularis	signal transduction protein lnk realted	0.0463	0.3158	0.3158
Loa Loa (eye worm)	STAT protein	0.0463	0.3158	0.3158
Onchocerca volvulus		0.0463	0.3158	0.3158
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0463	0.3158	0.3158
Onchocerca volvulus		0.078	1	1
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0463	0.3158	0.3158
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Schistosoma mansoni	nck2/grb4	0.0463	0.3158	0.3158
Loa Loa (eye worm)	hypothetical protein	0.0463	0.3158	0.3158
Schistosoma mansoni	tensin	0.0463	0.3158	0.3158
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0463	0.3158	0.3158
Echinococcus multilocularis	SH2 motif	0.0463	0.3158	0.3158
Echinococcus multilocularis	c src tyrosine kinase	0.078	1	1
Echinococcus granulosus	tyrosine kinase	0.078	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Brugia malayi	Tensin	0.0463	0.3158	0.3158
Brugia malayi	hypothetical protein	0.078	1	1
Onchocerca volvulus		0.0463	0.3158	0.3158
Schistosoma mansoni	SH2A	0.0463	0.3158	0.3158
Schistosoma mansoni	tensin	0.0463	0.3158	0.3158
Brugia malayi	SH2 domain containing protein	0.078	1	1
Trichomonas vaginalis	CAMK family protein kinase	0.0317	0	0.5
Echinococcus granulosus	tyrosine kinase	0.078	1	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0463	0.3158	0.3158
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0463	0.3158	0.3158
Loa Loa (eye worm)	hypothetical protein	0.0463	0.3158	0.3158
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0463	0.3158	0.3158
Echinococcus granulosus	tyrosine protein kinase ABL1	0.078	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Entamoeba histolytica	SH2 domain containing protein	0.0463	0.3158	0.3158
Toxoplasma gondii	protein kinase domain-containing protein	0.0317	0	0.5
Echinococcus multilocularis	SH2 domain containing protein 7	0.0463	0.3158	0.3158
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.078	1	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0463	0.3158	0.3158
Brugia malayi	SH2 domain containing protein	0.0463	0.3158	0.3158
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Schistosoma mansoni	signal transduction protein lnk-related	0.0463	0.3158	0.3158
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0463	0.3158	0.3158
Echinococcus granulosus	tyrosine protein kinase Fyn	0.078	1	1
Echinococcus multilocularis	tyrosine protein kinase Srms	0.078	1	1
Echinococcus multilocularis	NCK adaptor protein	0.0463	0.3158	0.3158
Brugia malayi	SH2 domain containing protein	0.0463	0.3158	0.3158
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0463	0.3158	0.3158
Brugia malayi	Protein kinase domain containing protein	0.078	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Onchocerca volvulus		0.0463	0.3158	0.3158
Echinococcus multilocularis	tyrosine kinase	0.078	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.078	1	1
Trypanosoma cruzi	protein kinase, putative	0.0317	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0463	0.3158	0.3158
Trichomonas vaginalis	protein kinase atn1, putative	0.0317	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Onchocerca volvulus		0.078	1	1
Brugia malayi	SH2 domain containing protein	0.0463	0.3158	0.3158
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Schistosoma mansoni	tyrosine kinase	0.078	1	1
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0463	0.3158	0.3158
Schistosoma mansoni	tyrosine kinase	0.078	1	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0317	0	0.5
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0317	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0463	0.3158	0.3158
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Schistosoma mansoni	tensin-related	0.0463	0.3158	0.3158
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Brugia malayi	Tyrosine-protein kinase abl-1	0.078	1	1
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0317	0	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0463	0.3158	0.3158
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Echinococcus granulosus	tyrosine protein kinase Src64B	0.078	1	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0317	0	0.5
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0463	0.3158	0.3158
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0317	0	0.5
Echinococcus multilocularis	tyrosine protein kinase shark	0.078	1	1
Onchocerca volvulus		0.0463	0.3158	0.3158
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.078	1	1
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0317	0	0.5
Plasmodium vivax	protein kinase, putative	0.0317	0	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0317	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0463	0.3158	0.3158
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0463	0.3158	0.3158
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.078	1	1
Giardia lamblia	Kinase, NEK	0.0317	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.078	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Leishmania major	protein kinase, putative	0.0317	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.078	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.078	1	1
Loa Loa (eye worm)	hypothetical protein	0.0463	0.3158	0.3158
Echinococcus granulosus	c src tyrosine kinase	0.078	1	1
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0463	0.3158	0.3158
Loa Loa (eye worm)	hypothetical protein	0.0463	0.3158	0.3158
Loa Loa (eye worm)	hypothetical protein	0.0463	0.3158	0.3158
Echinococcus granulosus	tyrosine protein kinase Fyn	0.078	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0463	0.3158	0.3158
Echinococcus granulosus	signal transduction protein lnk realted	0.0463	0.3158	0.3158
Leishmania major	hypothetical protein, conserved	0.0317	0	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0463	0.3158	0.3158
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.078	1	1
Loa Loa (eye worm)	TK/ABL protein kinase	0.078	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Plasmodium falciparum	tyrosine kinase-like protein	0.0317	0	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.078	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Schistosoma mansoni	growth factor receptor-bound protein	0.0463	0.3158	0.3158
Onchocerca volvulus		0.0463	0.3158	0.3158
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.078	1	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.0463	0.3158	0.3158
Loa Loa (eye worm)	TK/FER protein kinase	0.078	1	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0463	0.3158	0.3158
Schistosoma mansoni	hypothetical protein	0.0463	0.3158	0.3158
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Echinococcus granulosus	SH2 motif	0.0463	0.3158	0.3158
Echinococcus granulosus	tyrosine protein kinase shark	0.078	1	1
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0463	0.3158	0.3158
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.078	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0317	0	0.5
Schistosoma mansoni	shc transforming protein	0.0463	0.3158	0.3158
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0463	0.3158	0.3158
Schistosoma mansoni	suppressor of cytokine signaling	0.0463	0.3158	0.3158
Leishmania major	protein kinase, putative	0.0317	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.078	1	1
Echinococcus multilocularis	tyrosine protein kinase Abl	0.078	1	1
Schistosoma mansoni	tensin-related	0.0463	0.3158	0.3158

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 32 nM	Inhibition of SCD1 in ICR mouse liver microsome using [9,10 3H]- stearoyl-Coenzyme A substrate assessed as decreased production of tritiated water after 20 hrs by scintillation counting analysis	ChEMBL.	23245208
IC50 (binding)	= 325 nM	Inhibition of SCD1 in human HepG2 cells using [14C]-stearate substrate assessed as decreased production of [14C]-oleic acid after 24 hrs	ChEMBL.	23245208
Inhibition (binding)		Inhibition of delta5 desaturase in Sprague-Dawley rat liver microsome at 10 uM	ChEMBL.	23245208
Inhibition (binding)		Inhibition of delta6 desaturase in Sprague-Dawley rat liver microsome using cis,cis-9,12-octadecadienoic acid substrate at 10 uM	ChEMBL.	23245208
Papp (ADMET)	= 29 ucm/s	Apparent permeability from basolateral to apical side in human Caco2 cells	ChEMBL.	23245208

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2315112

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1741333