Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | lipase containing protein, putative | 0.0891 | 0.5 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0891 | 0.5 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.0891 | 0.5 | 0.5 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0891 | 0.5 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0891 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0891 | 0.5 | 0.5 | |
Loa Loa (eye worm) | lipase | 0.0891 | 0.5 | 0.5 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0891 | 0.5 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0891 | 0.5 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0891 | 0.5 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.0891 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 79 % | Binding affinity to mouse GAT1 expressed in HEK293 cells membranes assessed as remaining [2H10]NO711 binding level at 10 uM using LC-ESI-MS/MS analysis by [2H10]NO711 binding inhibition assay | ChEMBL. | 23336362 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.