Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | dual specificity mitogen activated protein | 0.858 | 1 | 1 |
Onchocerca volvulus | Kinase homolog | 0.019 | 0.0179 | 0.5 |
Loa Loa (eye worm) | STE/STE7/MEK7 protein kinase | 0.858 | 1 | 1 |
Echinococcus granulosus | dual specificity mitogen activated protein | 0.019 | 0.0179 | 0.0179 |
Trypanosoma brucei | protein kinase, putative | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | kinase | 0.019 | 0.0179 | 0.0179 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0037 | 0 | 0.5 |
Toxoplasma gondii | calcium dependent protein kinase CDPK8 | 0.0037 | 0 | 0.5 |
Trypanosoma brucei | STE/STE11 serine/threonine-protein kinase, putative | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | dual specificity mitogen activated protein | 0.019 | 0.0179 | 0.0179 |
Schistosoma mansoni | protein kinase | 0.858 | 1 | 1 |
Plasmodium falciparum | protein kinase, putative | 0.0037 | 0 | 0.5 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0037 | 0 | 0.5 |
Leishmania major | protein kinase, putative | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | dual specificity mitogen activated protein | 0.858 | 1 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0037 | 0 | 0.5 |
Loa Loa (eye worm) | STE/STE7/MEK7 protein kinase | 0.858 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 0 % | Inhibition of recombinant His6-tagged c-Myc bHLH-ZIP domain (353 to 437 amino acid residues) (unknown origin) assessed as disruption of Myc-Max dimerization at 100 uM by electrophoretic mobility shift assay relative to control | ChEMBL. | 23177256 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.