Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | potassium voltage-gated channel, shaker-related subfamily, member 5 | Starlite/ChEMBL | References |
Homo sapiens | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | voltage gated potassium channel | potassium voltage-gated channel, shaker-related subfamily, member 5 | 613 aa | 521 aa | 34.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Trypanosoma cruzi | ion transport protein, putative | 0.0121 | 0.8227 | 0.5 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.4241 | 0.4241 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0104 | 0.6855 | 0.6855 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Schistosoma mansoni | voltage-gated potassium channel | 0.0104 | 0.6855 | 0.6855 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.6855 | 0.6855 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.3647 | 0.3647 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0136 | 0.9437 | 0.9437 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily A | 0.0104 | 0.6855 | 0.6855 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0142 | 1 | 1 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Echinococcus multilocularis | small conductance calcium activated potassium | 0.0142 | 1 | 1 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Leishmania major | ion transport protein-like protein | 0.0121 | 0.8227 | 0.5 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0142 | 1 | 1 |
Trypanosoma cruzi | ion transport protein, putative | 0.0121 | 0.8227 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 1 | 1 |
Brugia malayi | Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit | 0.0104 | 0.6855 | 1 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0104 | 0.6855 | 0.6855 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0104 | 0.6855 | 0.6855 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Echinococcus multilocularis | potassium voltage gated channel subfamily A | 0.0099 | 0.6488 | 0.6488 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.12 uM | Inhibition of human Kv1.5 channel expressed in CHO cells by high throughput planar patch clamp assay | ChEMBL. | 23260347 |
IC50 (binding) | = 14 uM | Inhibition of IK channel (unknown origin) | ChEMBL. | 23260347 |
IC50 (binding) | > 33 uM | Inhibition of human ERG | ChEMBL. | 23260347 |
Papp (ADMET) | = 30 ucm/s | Apparent permeability of the compound in human Caco2 cells | ChEMBL. | 23260347 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.