Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | opioid receptor, delta 1 | Starlite/ChEMBL | References |
Mus musculus | opioid receptor, mu 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | tm gpcr rhodopsin | Get druggable targets OG5_139759 | All targets in OG5_139759 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | Get druggable targets OG5_139759 | All targets in OG5_139759 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | proto oncogene serine:threonine protein kinase | 0.0131 | 0.0201 | 0.0201 |
Echinococcus granulosus | proto oncogene serine:threonine protein kinase | 0.0131 | 0.0201 | 0.0201 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0131 | 0.0201 | 0.0201 |
Echinococcus multilocularis | sodium channel protein | 0.0724 | 0.161 | 0.161 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0131 | 0.0201 | 0.0201 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0645 | 0.1421 | 0.1421 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0047 | 0 | 0.5 |
Toxoplasma gondii | fructose-bisphospatase II | 0.4256 | 1 | 1 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0724 | 0.161 | 0.161 |
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.0724 | 0.161 | 0.161 |
Toxoplasma gondii | fructose-bisphospatase I | 0.1583 | 0.3649 | 0.3649 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0131 | 0.0201 | 0.0201 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.4256 | 1 | 1 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.4256 | 1 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0047 | 0 | 0.5 |
Trypanosoma brucei | sedoheptulose-1,7-bisphosphatase | 0.1583 | 0.3649 | 0.3649 |
Toxoplasma gondii | sedoheptulose-1,7-bisphosphatase | 0.1583 | 0.3649 | 0.3649 |
Brugia malayi | Serine/threonine-protein kinase Pim-3 | 0.0131 | 0.0201 | 0.0201 |
Onchocerca volvulus | Serine\/threonine protein kinase homolog | 0.0131 | 0.0201 | 1 |
Echinococcus granulosus | sodium channel protein | 0.0724 | 0.161 | 0.161 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.4256 | 1 | 1 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.4256 | 1 | 1 |
Leishmania major | 0.4256 | 1 | 1 | |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.1583 | 0.3649 | 0.3649 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0645 | 0.1421 | 0.1421 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.4256 | 1 | 1 |
Echinococcus multilocularis | calcium activated potassium channel | 0.0047 | 0.0001 | 0.0001 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.4256 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0131 | 0.0201 | 0.0201 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.1583 | 0.3649 | 0.3649 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.4256 | 1 | 1 |
Echinococcus granulosus | calcium activated potassium channel | 0.0047 | 0.0001 | 0.0001 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AD50 (functional) | = 0.9 uM kg-1 | Antinociceptive activity of the compound after subcutaneous administration in mice. p<0.05 vs dermorphin | ChEMBL. | 9986710 |
IC50 (functional) | = 35 nM | In vitro concentration of the compound required to inhibit electrically evoked twitch in isolated mouse vas deferens. | ChEMBL. | 9986710 |
Ki (binding) | = 0.5 nM | Displacement of [3H]-DAGO from Opioid receptor mu 1 of adult male mouse brain. | ChEMBL. | 9986710 |
Ki (binding) | = 1411 nM | Displacement of [3H]-NLT from Opioid receptor delta 1 of adult male mouse brain. | ChEMBL. | 9986710 |
T1/2 (ADMET) | = 20 min | Half-life time of enzymatic breakdown of the compound in mouse liver. | ChEMBL. | 9986710 |
T1/2 (ADMET) | = 30 min | Half-life time of enzymatic breakdown of the compound in mouse brain. | ChEMBL. | 9986710 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 9986710 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.