Detailed information for compound 1743817

Basic information

Technical information
  • TDR Targets ID: 1743817
  • Name: (2S,3S)-2-(2,4-difluorophenyl)-3-methylsulfon yl-1-(1,2,4-triazol-1-yl)butan-2-ol
  • MW: 331.338 | Formula: C13H15F2N3O3S
  • H donors: 1 H acceptors: 5 LogP: 0.61 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(c(c1)F)[C@@]([C@@H](S(=O)(=O)C)C)(Cn1cncn1)O
  • InChi: 1S/C13H15F2N3O3S/c1-9(22(2,20)21)13(19,6-18-8-16-7-17-18)11-4-3-10(14)5-12(11)15/h3-5,7-9,19H,6H2,1-2H3/t9-,13-/m0/s1
  • InChiKey: HFGZFHCWKKQGIS-ZANVPECISA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2S,3S)-2-(2,4-difluorophenyl)-3-mesyl-1-(1,2,4-triazol-1-yl)butan-2-ol
  • 134779-41-2
  • 1H-1,2,4-Triazole-1-ethanol, .alpha.-(2,4-difluorophenyl)-.alpha.-[(1S)-1-(methylsulfonyl)ethyl]-, (.alpha.S)-
  • AIDS-008724
  • AIDS008724
  • SCH 42426
  • (S,S)-SCH 39304
  • 1H-1,2,4-Triazole-1-ethanol, alpha-(2,4-difluorophenyl)-alpha-((1S)-1-(methylsulfonyl)ethyl)-, (alphaS)-
  • 1H-1,2,4-Triazole-1-ethanol, alpha-(2,4-difluorophenyl)-alpha-(1-(methylsulfonyl)ethyl)-, (S-(R*,R*))-
  • SCH42426
  • SM8668(S ISOMER)
  • (S,S)1-[1-(Methylsulfonyl)ethyl]-1-[1- triazolomethyl]-2,4-difluorophenylmethanol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0081 0.0153 0.0386
Brugia malayi Protein kinase domain containing protein 0.0138 0.1011 0.2553
Onchocerca volvulus 0.0081 0.0153 0.151
Echinococcus granulosus NCK adaptor protein 0.0081 0.0153 0.0153
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0138 0.1011 0.1011
Schistosoma mansoni growth factor receptor-bound protein 0.0081 0.0153 0.0176
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0138 0.1011 0.1011
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0081 0.0153 0.0176
Loa Loa (eye worm) RGC/RGC protein kinase 0.0128 0.0858 0.2167
Schistosoma mansoni tyrosine kinase 0.0138 0.1011 0.1163
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0138 0.1011 0.1011
Loa Loa (eye worm) hypothetical protein 0.0081 0.0153 0.0386
Onchocerca volvulus 0.0081 0.0153 0.151
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0081 0.0153 0.0386
Onchocerca volvulus 0.0138 0.1011 1
Schistosoma mansoni glutamate receptor AMPA 0.0335 0.3959 0.4556
Echinococcus multilocularis glutamate receptor 2 0.0406 0.5023 0.5023
Loa Loa (eye worm) TK/FER protein kinase 0.0138 0.1011 0.2553
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0081 0.0153 0.0153
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0406 0.5023 0.5023
Echinococcus multilocularis glutamate receptor 2 0.0267 0.2947 0.2947
Echinococcus granulosus nmda type glutamate receptor 0.0315 0.3666 0.3666
Echinococcus multilocularis tyrosine protein kinase Srms 0.0138 0.1011 0.1011
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0081 0.0153 0.151
Loa Loa (eye worm) TK/FER protein kinase 0.0138 0.1011 0.2553
Brugia malayi Variant SH3 domain containing protein 0.0081 0.0153 0.0386
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0138 0.1012 0.1012
Loa Loa (eye worm) hypothetical protein 0.0081 0.0153 0.0386
Loa Loa (eye worm) TK/ABL protein kinase 0.0138 0.1011 0.2553
Echinococcus granulosus SH2 domain containing adapter protein F 0.0081 0.0153 0.0153
Onchocerca volvulus 0.0138 0.1011 1
Echinococcus multilocularis SHC transforming protein 3 0.0081 0.0153 0.0153
Loa Loa (eye worm) STAT protein 0.0081 0.0153 0.0386
Echinococcus granulosus tyrosine protein kinase Srms 0.0138 0.1011 0.1011
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0081 0.0153 0.0176
Echinococcus granulosus tyrosine protein kinase Fyn 0.0138 0.1011 0.1011
Brugia malayi Protein kinase domain containing protein 0.0138 0.1011 0.2553
Echinococcus multilocularis signal transduction protein lnk realted 0.0081 0.0153 0.0153
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0355 0.4258 0.5
Echinococcus multilocularis SH2 motif 0.0081 0.0153 0.0153
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0138 0.1011 0.1011
Loa Loa (eye worm) RGC/RGC protein kinase 0.0128 0.0858 0.2167
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0406 0.5023 0.5023
Loa Loa (eye worm) hypothetical protein 0.0081 0.0153 0.0386
Echinococcus multilocularis NCK adaptor protein 0.0081 0.0153 0.0153
Brugia malayi Tensin 0.0081 0.0153 0.0386
Echinococcus granulosus SH2 domain containing protein 7 0.0081 0.0153 0.0153
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0406 0.5023 0.5023
Brugia malayi Variant SH3 domain containing protein 0.0081 0.0153 0.0386
Loa Loa (eye worm) hypothetical protein 0.0081 0.0153 0.0386
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0138 0.1011 0.1011
Echinococcus multilocularis glutamate receptor 2 0.0335 0.3959 0.3959
Echinococcus granulosus tyrosine kinase 0.0138 0.1011 0.1011
Schistosoma mansoni tensin 0.0081 0.0153 0.0176
Onchocerca volvulus 0.0128 0.0858 0.849
Brugia malayi Protein kinase domain containing protein 0.0138 0.1011 0.2553
Echinococcus granulosus SH2 motif 0.0081 0.0153 0.0153
Echinococcus granulosus expressed conserved protein 0.0081 0.0153 0.0153
Echinococcus granulosus glutamate receptor 2 0.0406 0.5023 0.5023
Onchocerca volvulus 0.0081 0.0153 0.151
Brugia malayi SH2 domain containing protein 0.0081 0.0153 0.0386
Loa Loa (eye worm) hypothetical protein 0.0128 0.0858 0.2167
Echinococcus granulosus tyrosine protein kinase Lyn 0.0138 0.1011 0.1011
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0138 0.1012 0.1012
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0081 0.0153 0.0386
Schistosoma mansoni glutamate receptor AMPA 0.0335 0.3959 0.4556
Brugia malayi Variant SH3 domain containing protein 0.0081 0.0153 0.0386
Onchocerca volvulus 0.0138 0.1011 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0138 0.1011 0.1011
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0406 0.5023 0.5023
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0138 0.1012 0.1012
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0081 0.0153 0.0153
Echinococcus granulosus suppressor of cytokine signaling 7 0.0081 0.0153 0.0153
Entamoeba histolytica protein kinase, putative 0.0081 0.0153 0.151
Chlamydia trachomatis glutamine binding protein 0.0355 0.4258 0.5
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0138 0.1011 1
Schistosoma mansoni tyrosine kinase 0.0128 0.0858 0.0987
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0081 0.0153 0.0386
Schistosoma mansoni hypothetical protein 0.0081 0.0153 0.0176
Loa Loa (eye worm) TK/FER protein kinase 0.0138 0.1011 0.2553
Brugia malayi SH2 domain containing protein 0.0081 0.0153 0.0386
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0138 0.1011 0.1011
Loa Loa (eye worm) hypothetical protein 0.0081 0.0153 0.0386
Onchocerca volvulus 0.0138 0.1011 1
Echinococcus multilocularis c src tyrosine kinase 0.0138 0.1011 0.1011
Brugia malayi Glycosyl hydrolases family 31 protein 0.0191 0.1803 0.4554
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0138 0.1011 0.1011
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0138 0.1011 0.1011
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0138 0.1012 0.1012
Echinococcus granulosus tyrosine protein kinase ABL1 0.0138 0.1011 0.1011
Entamoeba histolytica SH2 domain containing protein 0.0081 0.0153 0.151
Loa Loa (eye worm) TK/FER protein kinase 0.0138 0.1011 0.2553
Schistosoma mansoni shc transforming protein 0.0081 0.0153 0.0176
Echinococcus granulosus tyrosine protein kinase Blk 0.0138 0.1011 0.1011
Brugia malayi tRNA modification GTPase TrmE family protein 0.0081 0.0153 0.0386
Loa Loa (eye worm) hypothetical protein 0.0081 0.0153 0.0386
Echinococcus multilocularis glutamate receptor NMDA 0.0244 0.2602 0.2602
Echinococcus multilocularis lysosomal alpha glucosidase 0.0191 0.1803 0.1803
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0138 0.1011 0.1011
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0081 0.0153 0.0176
Echinococcus multilocularis tensin 0.0081 0.0153 0.0153
Loa Loa (eye worm) glutamate receptor 1 0.0335 0.3959 1
Echinococcus granulosus signal transduction protein lnk realted 0.0081 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0081 0.0153 0.0386
Echinococcus granulosus hypothetical protein 0.0081 0.0153 0.0153
Echinococcus granulosus tyrosine protein kinase Src64B 0.0138 0.1011 0.1011
Echinococcus granulosus tyrosine protein kinase Fyn 0.0138 0.1011 0.1011
Echinococcus multilocularis tyrosine protein kinase Abl 0.0138 0.1011 0.1011
Loa Loa (eye worm) hypothetical protein 0.0081 0.0153 0.0386
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0138 0.1011 0.1011
Loa Loa (eye worm) SH2 domain-containing protein 0.0081 0.0153 0.0386
Loa Loa (eye worm) TK protein kinase 0.0138 0.1011 0.2553
Schistosoma mansoni tyrosine kinase 0.0138 0.1011 0.1163
Brugia malayi Glutamate receptor 1 precursor 0.0335 0.3959 1
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0355 0.4258 0.5
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0138 0.1012 0.1012
Echinococcus multilocularis receptor type guanylyl cyclase 0.0128 0.0858 0.0858
Schistosoma mansoni tyrosine kinase 0.0138 0.1011 0.1163
Brugia malayi Sex muscle abnormal protein 5 0.0081 0.0153 0.0386
Echinococcus granulosus growth factor receptor bound protein 2 0.0081 0.0153 0.0153
Echinococcus granulosus lysosomal alpha glucosidase 0.0191 0.1803 0.1803
Brugia malayi Protein kinase domain containing protein 0.0138 0.1011 0.2553
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0081 0.0153 0.0153
Echinococcus granulosus suppressor of cytokine signaling 6 0.0081 0.0153 0.0153
Trypanosoma cruzi extracellular receptor, putative 0.0071 0 0.5
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0081 0.0153 0.0153
Echinococcus granulosus SH2 motif 0.0081 0.0153 0.0153
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0081 0.0153 0.0153
Brugia malayi RhoGAP domain containing protein 0.0081 0.0153 0.0386
Loa Loa (eye worm) SRC-1 0.0138 0.1011 0.2553
Schistosoma mansoni hypothetical protein 0.0081 0.0153 0.0176
Echinococcus multilocularis tyrosine kinase 0.0128 0.0858 0.0858
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0081 0.0153 0.0153
Onchocerca volvulus 0.0111 0.0594 0.5877
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0081 0.0153 0.0386
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0128 0.0858 0.849
Echinococcus granulosus tyrosine protein kinase shark 0.0138 0.1011 0.1011
Onchocerca volvulus 0.0081 0.0153 0.151
Onchocerca volvulus 0.0081 0.0153 0.151
Loa Loa (eye worm) hypothetical protein 0.0081 0.0153 0.0386
Schistosoma mansoni glutamate receptor NMDA 0.065 0.8689 1
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0138 0.1011 0.1011
Onchocerca volvulus 0.0138 0.1011 1
Echinococcus multilocularis nmda type glutamate receptor 0.0737 1 1
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0081 0.0153 0.0153
Echinococcus granulosus N chimaerin 0.0081 0.0153 0.0153
Echinococcus granulosus glutamate receptor subunit protein glur 0.0138 0.1012 0.1012
Onchocerca volvulus 0.0138 0.1011 1
Schistosoma mansoni adapter molecule crk 0.0081 0.0153 0.0176
Brugia malayi Glutamate receptor 2 precursor 0.0335 0.3959 1
Brugia malayi Protein kinase domain containing protein 0.0138 0.1011 0.2553
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0355 0.4258 0.5
Echinococcus multilocularis N chimaerin 0.0081 0.0153 0.0153
Echinococcus granulosus tyrosine kinase 0.0128 0.0858 0.0858
Echinococcus granulosus receptor type guanylyl cyclase 0.0128 0.0858 0.0858
Onchocerca volvulus 0.0081 0.0153 0.151
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0081 0.0153 0.0153
Brugia malayi SRC-1 0.0138 0.1011 0.2553
Brugia malayi hypothetical protein 0.0138 0.1011 0.2553
Echinococcus multilocularis tyrosine protein kinase shark 0.0138 0.1011 0.1011
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0406 0.5023 0.5023
Schistosoma mansoni tyrosine kinase 0.0128 0.0858 0.0987
Schistosoma mansoni tyrosine kinase 0.0138 0.1011 0.1163
Brugia malayi STAT protein, DNA binding domain containing protein 0.0081 0.0153 0.0386
Brugia malayi SH2 domain containing protein 0.0081 0.0153 0.0386
Schistosoma mansoni suppressor of cytokine signaling 0.0081 0.0153 0.0176
Loa Loa (eye worm) SH2 domain-containing protein 0.0081 0.0153 0.0386
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0081 0.0153 0.0153
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0081 0.0153 0.151
Echinococcus multilocularis 0.0081 0.0153 0.0153
Brugia malayi hypothetical protein 0.0081 0.0153 0.0386
Schistosoma mansoni protein kinase 0.0128 0.0858 0.0987
Schistosoma mansoni tensin-related 0.0081 0.0153 0.0176
Echinococcus multilocularis NMDA receptor 0.0138 0.1012 0.1012
Echinococcus multilocularis tyrosine protein kinase Blk 0.0138 0.1011 0.1011
Loa Loa (eye worm) TK/FER protein kinase 0.0138 0.1011 0.2553
Brugia malayi SH2 domain containing protein 0.0138 0.1011 0.2553
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0191 0.1803 0.4554
Loa Loa (eye worm) TK/FER protein kinase 0.0138 0.1011 0.2553
Schistosoma mansoni glutamate receptor kainate 0.0335 0.3959 0.4556
Loa Loa (eye worm) hypothetical protein 0.0081 0.0153 0.0386
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0406 0.5023 0.5023
Loa Loa (eye worm) hypothetical protein 0.0138 0.1011 0.2553
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0081 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0081 0.0153 0.0386
Schistosoma mansoni tensin 0.0081 0.0153 0.0176
Schistosoma mansoni glutamate receptor kainate 0.0335 0.3959 0.4556
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0406 0.5023 0.5023
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0138 0.1011 0.1011
Schistosoma mansoni SH2A 0.0081 0.0153 0.0176
Echinococcus multilocularis nmda type glutamate receptor 0.0315 0.3666 0.3666
Schistosoma mansoni suppressor of cytokine signaling 0.0081 0.0153 0.0176
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0081 0.0153 0.0386
Brugia malayi SH2 domain containing protein 0.0081 0.0153 0.0386
Schistosoma mansoni tensin-related 0.0081 0.0153 0.0176
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0081 0.0153 0.0386
Schistosoma mansoni GTPase activating protein 0.0081 0.0153 0.0176
Echinococcus multilocularis lysosomal alpha glucosidase 0.0191 0.1803 0.1803
Loa Loa (eye worm) RGC/RGC protein kinase 0.0128 0.0858 0.2167
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0138 0.1011 0.1011
Echinococcus granulosus tyrosine protein kinase Src42A 0.0081 0.0153 0.0153
Brugia malayi Tyrosine-protein kinase abl-1 0.0138 0.1011 0.2553
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0138 0.1011 0.1011
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0081 0.0153 0.0176
Echinococcus granulosus tyrosine kinase 0.0138 0.1011 0.1011
Loa Loa (eye worm) hypothetical protein 0.0081 0.0153 0.0386
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0138 0.1011 0.1011
Brugia malayi cytokine inducible SH2-containing protein 5 0.0081 0.0153 0.0386
Echinococcus granulosus tyrosine protein kinase Src42A 0.0138 0.1011 0.1011
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0081 0.0153 0.0176
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0138 0.1011 0.1011
Schistosoma mansoni glutamate receptor NMDA 0.0335 0.3959 0.4556
Echinococcus multilocularis SH2 motif 0.0081 0.0153 0.0153
Schistosoma mansoni tensin 0.0081 0.0153 0.0176
Loa Loa (eye worm) SH2 domain-containing protein 0.0081 0.0153 0.0386
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0335 0.3959 0.3959
Echinococcus multilocularis tyrosine kinase 0.0138 0.1011 0.1011
Schistosoma mansoni ATP-binding cassette transporter 0.0335 0.3959 0.4556
Loa Loa (eye worm) TK/FER protein kinase 0.0138 0.1011 0.2553
Schistosoma mansoni nck2/grb4 0.0081 0.0153 0.0176
Echinococcus granulosus tyrosine protein kinase Fyn 0.0138 0.1011 0.1011
Loa Loa (eye worm) hypothetical protein 0.0081 0.0153 0.0386
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0081 0.0153 0.151
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0138 0.1011 0.1011
Echinococcus multilocularis SH2 domain containing protein 7 0.0081 0.0153 0.0153
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0355 0.4258 0.5
Echinococcus granulosus tensin 0.0081 0.0153 0.0153
Brugia malayi SH2 domain containing protein 0.0138 0.1011 0.2553
Echinococcus multilocularis tensin 0.0081 0.0153 0.0153
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0081 0.0153 0.0153
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0081 0.0153 0.0153
Echinococcus multilocularis SH2 motif 0.0081 0.0153 0.0153
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0406 0.5023 0.5023
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0493 0.6334 0.6334
Brugia malayi Guanylyl cyclase protein 23 0.0128 0.0858 0.2167
Schistosoma mansoni vav2 0.0081 0.0153 0.0176
Loa Loa (eye worm) glutamate receptor 2 0.0335 0.3959 1
Brugia malayi protein-tyrosine kinase 0.0138 0.1011 0.2553
Schistosoma mansoni hypothetical protein 0.0138 0.1012 0.1165
Brugia malayi SH2 domain containing protein 0.0081 0.0153 0.0386
Loa Loa (eye worm) TK/FER protein kinase 0.0138 0.1011 0.2553
Schistosoma mansoni alpha-glucosidase 0.0164 0.1403 0.1615
Schistosoma mansoni glutamate receptor kainate 0.0335 0.3959 0.4556
Echinococcus granulosus glutamate receptor NMDA 0.0244 0.2602 0.2602
Echinococcus granulosus SHC transforming protein 3 0.0081 0.0153 0.0153
Schistosoma mansoni tyrosine kinase 0.0138 0.1011 0.1163
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0355 0.4258 0.5
Schistosoma mansoni signal transduction protein lnk-related 0.0081 0.0153 0.0176
Echinococcus granulosus glutamate NMDA receptor subunit 0.0335 0.3959 0.3959
Brugia malayi Receptor family ligand binding region containing protein 0.0128 0.0858 0.2167
Echinococcus multilocularis growth factor receptor bound protein 2 0.0081 0.0153 0.0153
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0081 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0081 0.0153 0.0386
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0138 0.1012 0.1012
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0138 0.1011 0.1163
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0081 0.0153 0.0153
Echinococcus granulosus glutamate receptor 2 0.0267 0.2947 0.2947
Leishmania major extracellular receptor, putative 0.0071 0 0.5
Brugia malayi SH2 domain containing protein 0.0081 0.0153 0.0386
Brugia malayi Variant SH3 domain containing protein 0.0081 0.0153 0.0386
Brugia malayi SH2 domain containing protein 0.0081 0.0153 0.0386
Echinococcus granulosus c src tyrosine kinase 0.0138 0.1011 0.1011
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0081 0.0153 0.0386
Schistosoma mansoni alpha-glucosidase 0.0164 0.1403 0.1615
Loa Loa (eye worm) TK/FER protein kinase 0.0138 0.1011 0.2553
Schistosoma mansoni tyrosine kinase 0.0138 0.1011 0.1163
Schistosoma mansoni growth factor receptor-bound protein 0.0081 0.0153 0.0176
Loa Loa (eye worm) TK/FER protein kinase 0.0138 0.1011 0.2553

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) > 25 mg kg-1 Effective dose of the compound was determined against Candida albicans KB-8 strain after iv administration in murine ChEMBL. No reference
ED50 (functional) > 25 mg kg-1 Effective dose of the compound was determined against Aspergillus fumigatus MTU6001 strain after iv administration in murine ChEMBL. No reference
ED50 (functional) > 100 mg kg-1 Effective dose of the compound was determined against Candida albicans KB-8 strain after po administration in murine ChEMBL. No reference
ED50 (functional) > 125 mg kg-1 Effective dose of the compound was determined against Aspergillus fumigatus MTU6001 strain after po administration in murine ChEMBL. No reference
MIC (functional) = 50 ug ml-1 Minimum inhibitory concentration required for in vitro antifungal activity against Candida albicans KB-8 strain ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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