Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0112 | 0.5 | 0.5 | |
Onchocerca volvulus | 0.0112 | 0.5 | 0.5 | |
Onchocerca volvulus | 0.0112 | 0.5 | 0.5 | |
Onchocerca volvulus | 0.0112 | 0.5 | 0.5 | |
Schistosoma mansoni | subfamily M14A unassigned peptidase (M14 family) | 0.0112 | 0.5 | 0.5 |
Echinococcus multilocularis | subfamily M14A unassigned peptidase | 0.0112 | 0.5 | 0.5 |
Onchocerca volvulus | Subfamily M14A unassigned peptidase homolog | 0.0112 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | uM | Inhibition constant for the non time dependent inhibition of Cathepsin H; no inhibition | ChEMBL. | 10052963 |
Ki (binding) | = 160 uM | Inhibition constant for the non time dependent inhibition of Cathepsin H | ChEMBL. | 10052963 |
ki/Ki (binding) | = 67 M-1 min-1 | Evaluated for second-order rate constants for the inactivation of mammalian lysosomal cathepsin B. | ChEMBL. | 10052963 |
ki/Ki (binding) | = 73 M-1 min-1 | Compound was evaluated for second-order rate constants for the inactivation of papain (vacuolar plant enzyme) | ChEMBL. | 10052963 |
ki/Ki (binding) | = 305 M-1 min-1 | Evaluated for second-order rate constants for the inactivation of mammalian lysosomal cathepsin L. | ChEMBL. | 10052963 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.