Detailed information for compound 1744705

Basic information

Technical information
  • TDR Targets ID: 1744705
  • Name: 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxol an-2-yl]-5-(3-methyl-1,2-oxazol-5-yl)pyrimidi ne-2,4-dione
  • MW: 309.275 | Formula: C13H15N3O6
  • H donors: 3 H acceptors: 5 LogP: -0.81 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H]1O[C@H](C[C@@H]1O)n1cc(c2onc(c2)C)c(=O)[nH]c1=O
  • InChi: 1S/C13H15N3O6/c1-6-2-9(22-15-6)7-4-16(13(20)14-12(7)19)11-3-8(18)10(5-17)21-11/h2,4,8,10-11,17-18H,3,5H2,1H3,(H,14,19,20)/t8-,10+,11+/m0/s1
  • InChiKey: GBLOVFDLOVVYPI-JMJZKYOTSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-(3-methylisoxazol-5-yl)pyrimidine-2,4-dione
  • 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-2-tetrahydrofuranyl]-5-(3-methyl-5-isoxazolyl)pyrimidine-2,4-dione
  • 1-[(2R,4S,5R)-4-hydroxy-5-methylol-tetrahydrofuran-2-yl]-5-(3-methylisoxazol-5-yl)pyrimidine-2,4-quinone
  • 133040-32-1
  • AIDS-191199
  • AIDS191199
  • 1-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-(3-methyl-isoxazol-5-yl)-1H-pyrimidine-2,4-dione

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0526 0.3822 0.3822
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0136 0.0684 0.0684
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0241 0.1534 0.1534
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0127 0.0615 0.0615
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0136 0.0684 1
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0258 0.1671 0.1671
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0136 0.0684 0.0684
Loa Loa (eye worm) hypothetical protein 0.03 0.2005 0.5244
Echinococcus granulosus histone deacetylase 0.0148 0.0783 0.0783
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0136 0.0684 0.4096
Echinococcus multilocularis serotonin transporter 0.03 0.2005 0.2005
Trichomonas vaginalis conserved hypothetical protein 0.0136 0.0684 1
Echinococcus multilocularis histone deacetylase 6 0.0148 0.0783 0.0783
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0136 0.0684 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0136 0.0684 0.0684
Echinococcus granulosus Protein Red 0.0105 0.0438 0.0438
Brugia malayi Sodium:neurotransmitter symporter family protein 0.03 0.2005 0.5244
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0059 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0054 0.0024 0.0063
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0136 0.0684 0.0684
Toxoplasma gondii RED family protein 0.0105 0.0438 0.0438
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0136 0.0684 0.0684
Loa Loa (eye worm) hypothetical protein 0.0136 0.0684 0.179
Loa Loa (eye worm) serotonin transporter b 0.03 0.2005 0.5244
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0258 0.1671 0.6316
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0136 0.0684 1
Loa Loa (eye worm) hypothetical protein 0.0136 0.0684 0.179
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0136 0.0684 0.0684
Loa Loa (eye worm) solute carrier family 6 member 4 0.03 0.2005 0.5244
Plasmodium falciparum phosphodiesterase gamma, putative 0.0136 0.0684 0.0684
Echinococcus granulosus histone deacetylase 6 0.0148 0.0783 0.0783
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0136 0.0684 0.0684
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0136 0.0684 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0136 0.0684 0.0684
Schistosoma mansoni voltage-gated potassium channel 0.0062 0.0091 0.0091
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.016 0.0878 0.0878
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0684 1
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.1293 1 1
Trypanosoma cruzi histone deacetylase, putative 0.0148 0.0783 0.0629
Plasmodium vivax phosphodiesterase gamma, putative 0.0136 0.0684 0.4096
Schistosoma mansoni red protein (ik factor) (cytokine ik) 0.0105 0.0438 0.0438
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0136 0.0684 1
Schistosoma mansoni voltage-gated potassium channel 0.0108 0.0455 0.0455
Loa Loa (eye worm) hypothetical protein 0.039 0.2727 0.7135
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0136 0.0684 0.0684
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0136 0.0684 0.4096
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.016 0.0878 0.0878
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0526 0.3822 0.3822
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.1293 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0104 0.0425 0.0425
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0127 0.0615 0.1609
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0136 0.0684 0.0684
Toxoplasma gondii histone deacetylase HDAC1 0.0148 0.0783 0.0783
Schistosoma mansoni voltage-gated potassium channel 0.0108 0.0455 0.0455
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0258 0.1671 0.1671
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0136 0.0684 0.0684
Loa Loa (eye worm) hypothetical protein 0.0108 0.0455 0.1191
Echinococcus granulosus serotonin transporter 0.03 0.2005 0.2005
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0136 0.0684 0.179
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0136 0.0684 0.0684
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0258 0.1671 0.1671
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0136 0.0684 0.0684
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0684 1
Giardia lamblia hypothetical protein 0.0136 0.0684 0.5
Mycobacterium ulcerans ion transport protein 0.0097 0.0367 0.5
Loa Loa (eye worm) hypothetical protein 0.0195 0.1163 0.3043
Trichomonas vaginalis conserved hypothetical protein 0.0136 0.0684 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0136 0.0684 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0136 0.0684 0.179
Schistosoma mansoni sodium/chloride dependent transporter 0.03 0.2005 0.2005
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0136 0.0684 0.0684
Trichomonas vaginalis conserved hypothetical protein 0.0136 0.0684 1
Trypanosoma cruzi histone deacetylase, putative 0.0148 0.0783 0.0629
Loa Loa (eye worm) PDE1B protein 0.0526 0.3822 1
Trypanosoma cruzi ion transport protein, putative 0.033 0.2246 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0684 1
Schistosoma mansoni histone deacetylase hda2 0.0148 0.0783 0.0783
Trypanosoma brucei histone deacetylase 3 0.0148 0.0783 0.0996
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0136 0.0684 1
Echinococcus multilocularis histone deacetylase 6 0.0148 0.0783 0.0783
Echinococcus multilocularis histone deacetylase 6 0.0148 0.0783 0.0783
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0136 0.0684 0.179
Echinococcus multilocularis sodium channel protein 0.0241 0.1534 0.1534
Onchocerca volvulus 0.03 0.2005 1
Loa Loa (eye worm) hypothetical protein 0.03 0.2005 0.5244
Echinococcus multilocularis histone deacetylase 0.0148 0.0783 0.0783
Brugia malayi Histone deacetylase family protein 0.0148 0.0783 0.2047
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0136 0.0684 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0136 0.0684 0.0684
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0136 0.0684 0.0684
Leishmania major histone deacetylase, putative 0.0148 0.0783 0.0629
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0136 0.0684 1
Treponema pallidum sodium- and chloride- dependent transporter 0.03 0.2005 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0136 0.0684 0.0684
Echinococcus multilocularis potassium voltage gated channel protein 0.0108 0.0455 0.0455
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0136 0.0684 1
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0136 0.0684 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0136 0.0684 0.0684
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0136 0.0684 0.0684
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0127 0.0615 0.0615
Leishmania major ion transport protein-like protein 0.033 0.2246 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0684 1
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0136 0.0684 0.0684
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0136 0.0684 0.0684
Loa Loa (eye worm) hypothetical protein 0.0136 0.0684 0.179
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0136 0.0684 0.0684
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0684 1
Loa Loa (eye worm) hypothetical protein 0.0136 0.0684 0.179
Giardia lamblia Hypothetical protein 0.0136 0.0684 0.5
Loa Loa (eye worm) voltage-gated potassium channel 0.0103 0.0422 0.1103
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0108 0.0455 0.1191
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0136 0.0684 1
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0136 0.0684 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0136 0.0684 1
Trypanosoma brucei histone deacetylase 4 0.0148 0.0783 0.0996
Brugia malayi Suppressor of mec and unc defects protein 0.0105 0.0438 0.1146
Echinococcus granulosus histone deacetylase 6 0.0148 0.0783 0.0783
Trypanosoma brucei histone deacetylase, putative 0.0148 0.0783 0.0996
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0108 0.0455 0.0455
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0136 0.0684 1
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0136 0.0684 0.0684
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0136 0.0684 0.179
Trypanosoma cruzi ion transport protein, putative 0.033 0.2246 1
Echinococcus granulosus potassium voltage gated channel protein 0.0108 0.0455 0.0455
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0136 0.0684 1
Loa Loa (eye worm) hypothetical protein 0.0175 0.1002 0.2621
Schistosoma mansoni calcium-activated potassium channel 0.0371 0.2574 0.2574
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0136 0.0684 0.0684
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0684 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0136 0.0684 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.0424 0.1109
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0684 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0526 0.3822 1
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0241 0.1534 0.544
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0684 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0136 0.0684 0.0684
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0684 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0136 0.0684 0.179
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0127 0.0615 0.0615
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0136 0.0684 0.0684
Schistosoma mansoni hypothetical protein 0.039 0.2727 0.2727
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0136 0.0684 1
Schistosoma mansoni histone deacetylase 4 5 0.0148 0.0783 0.0783
Loa Loa (eye worm) histone deacetylase 7A 0.0148 0.0783 0.2047
Plasmodium vivax histone deacetylase, putative 0.0148 0.0783 0.4684
Plasmodium vivax histone deacetylase 2, putative 0.0148 0.0783 0.4684
Schistosoma mansoni calcium-activated potassium channel 0.039 0.2727 0.2727
Echinococcus multilocularis histone deacetylase 7 0.0148 0.0783 0.0783
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0258 0.1671 1
Plasmodium falciparum phosphodiesterase delta, putative 0.0136 0.0684 0.0684
Schistosoma mansoni histone deacetylase 4 5 0.0148 0.0783 0.0783
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.1293 1 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0684 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.03 0.2005 0.2005
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0136 0.0684 0.0684
Loa Loa (eye worm) histone deacetylase 0.0148 0.0783 0.2047
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0258 0.1671 1
Brugia malayi Histone deacetylase family protein 0.0148 0.0783 0.2047
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0684 1
Schistosoma mansoni voltage-gated potassium channel 0.0062 0.0091 0.0091
Echinococcus multilocularis Protein Red 0.0105 0.0438 0.0438
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0136 0.0684 1
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0059 0.0064 0.0167
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0136 0.0684 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0684 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.0424 0.1109
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0136 0.0684 0.0684
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0136 0.0684 0.0684
Plasmodium falciparum histone deacetylase, putative 0.0148 0.0783 0.0783
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0136 0.0684 0.0684
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0136 0.0684 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0136 0.0684 1
Loa Loa (eye worm) norepinephrine transporter 0.03 0.2005 0.5244
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0684 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0136 0.0684 0.0684
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0684 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0136 0.0684 0.0684
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0684 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0684 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0258 0.1671 0.1671
Echinococcus multilocularis small conductance calcium activated potassium 0.039 0.2727 0.2727
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0136 0.0684 0.179
Echinococcus granulosus histone deacetylase 7 0.0148 0.0783 0.0783
Echinococcus granulosus sodium channel protein 0.0241 0.1534 0.1534
Trypanosoma cruzi histone deacetylase, putative 0.0148 0.0783 0.0629
Leishmania major histone deacetylase, putative 0.0148 0.0783 0.0629
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0136 0.0684 1
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0051 0 0.5
Plasmodium falciparum histone deacetylase 2 0.0148 0.0783 0.0783
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0258 0.1671 0.6316
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0136 0.0684 0.0684
Echinococcus granulosus histone deacetylase 6 0.0148 0.0783 0.0783
Echinococcus granulosus small conductance calcium activated potassium 0.039 0.2727 0.2727
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0258 0.1671 0.6316
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.1293 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0059 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.03 0.2005 0.5244
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0684 1
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0136 0.0684 0.0684
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0136 0.0684 0.5
Loa Loa (eye worm) hypothetical protein 0.0105 0.0438 0.1146
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0136 0.0684 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0136 0.0684 1
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0526 0.3822 0.3822
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0684 1
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0059 0.0064 0.0167
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0136 0.0684 0.0684

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 40 ug ml-1 Minimum inhibitory concentration required to reduce virus induced cytopathicity in embryonic skin muscle (E6SM) cell culture of virus HSV-1( F) was measured ChEMBL. 2061920
MIC (functional) = 52 ug ml-1 Minimum inhibitory concentration required to reduce virus induced plaque formation in HEL cell culture of virus VZS (YS) was measured ChEMBL. 2061920
MIC (functional) = 70 ug ml-1 Minimum inhibitory concentration required to reduce virus induced cytopathicity in embryonic skin muscle (E6SM) cell culture of virus HSV-1 (KOS) was measured ChEMBL. 2061920
MIC (functional) = 70 ug ml-1 Minimum inhibitory concentration required to reduce virus induced cytopathicity in embryonic skin muscle (E6SM) cell culture of virus HSV-1 (Mc Intyre) was measured ChEMBL. 2061920
MIC (functional) = 87 ug ml-1 Minimum inhibitory concentration required to reduce virus induced plaque formation in HEL cell culture of virus VZS (OKA) was measured ChEMBL. 2061920
MIC (functional) > 200 ug ml-1 Compound was evaluated in vitro for antiviral activity and cytotoxicity, and minimum inhibitory concentration required to reduce cell growth by 50% in HEL cell culture ChEMBL. 2061920
MIC (functional) = 250 ug ml-1 Minimum inhibitory concentration required to reduce virus induced plaque formation in HEL cell culture of virus CMV (Davis) was measured ChEMBL. 2061920
MIC (functional) > 400 ug ml-1 Minimum inhibitory concentration required to reduce virus induced cytopathicity in embryonic skin muscle (E6SM) cell culture of virus HSV-2 (G) was measured ChEMBL. 2061920
MIC (functional) > 400 ug ml-1 Minimum inhibitory concentration required to reduce virus induced cytopathicity in embryonic skin muscle (E6SM) cell culture of virus HSV-2 (196) was measured. ChEMBL. 2061920
MIC (functional) > 400 ug ml-1 Minimum inhibitory concentration required to reduce virus induced cytopathicity in embryonic skin muscle (E6SM) cell culture of virus HSV-2 (Lyons) was measured. ChEMBL. 2061920
MIC (functional) > 400 ug ml-1 Minimum inhibitory concentration required to reduce virus induced cytopathicity in embryonic skin muscle (E6SM) cell culture of virus TK- HSV-1 (B2006) was measured ChEMBL. 2061920
MIC (functional) > 400 ug ml-1 Minimum inhibitory concentration required to reduce virus induced cytopathicity in embryonic skin muscle (E6SM) cell culture of virus TK- HSV-1 (VMW1837) was measured ChEMBL. 2061920
MIC (functional) > 400 ug ml-1 Minimum concentration required to reduce virus induced plaque formation in HEL cell culture of virus TK- VZV (YS-R) was measured ChEMBL. 2061920
MIC (functional) > 400 ug ml-1 Minimum inhibitory concentration required to reduce virus induced plaque formation in HEL cell culture of virus TK- VZV (07-1) was measured ChEMBL. 2061920
MIC (functional) > 400 ug ml-1 Minimum inhibitory concentration required to reduce virus induced cytopathicity in embryonic skin muscle (E6SM) cell culture of virus VSV was measured ChEMBL. 2061920
MIC (functional) > 400 ug ml-1 Minimum inhibitory concentration required to reduce virus induced cytopathicity in embryonic skin muscle (E6SM) cell culture of virus VV was measured ChEMBL. 2061920
MIC (functional) > 400 ug ml-1 minimum inhibitory concentration required to to cause a microscopically detectable change in normal cell morphology ChEMBL. 2061920

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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