Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | gonadotropin-releasing hormone receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | GnHR receptor homolog | Get druggable targets OG5_131719 | All targets in OG5_131719 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | hexokinase, putative | 0.0337 | 0.5195 | 0.5 |
Plasmodium falciparum | hexokinase | 0.0337 | 0.5195 | 0.5 |
Trypanosoma cruzi | hexokinase, putative | 0.0337 | 0.5195 | 0.5 |
Toxoplasma gondii | hexokinase | 0.0337 | 0.5195 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0337 | 0.5195 | 0.5 |
Onchocerca volvulus | 0.0337 | 0.5195 | 1 | |
Echinococcus multilocularis | hexokinase type 2 | 0.0337 | 0.5195 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.023 | 0.2878 | 0.5396 |
Plasmodium vivax | hexokinase, putative | 0.0337 | 0.5195 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0337 | 0.5195 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0337 | 0.5195 | 1 |
Echinococcus granulosus | hexokinase | 0.0337 | 0.5195 | 1 |
Brugia malayi | hexokinase type II | 0.0107 | 0.0223 | 0.0063 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.0223 | 0.0123 |
Echinococcus multilocularis | hexokinase | 0.0337 | 0.5195 | 1 |
Trypanosoma brucei | hexokinase | 0.0337 | 0.5195 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0337 | 0.5195 | 1 |
Echinococcus multilocularis | hexokinase | 0.0337 | 0.5195 | 1 |
Trypanosoma cruzi | hexokinase, putative | 0.0337 | 0.5195 | 0.5 |
Treponema pallidum | hexokinase (hxk) | 0.0337 | 0.5195 | 0.5 |
Schistosoma mansoni | hexokinase | 0.0337 | 0.5195 | 1 |
Brugia malayi | Hexokinase family protein | 0.0337 | 0.5195 | 0.5117 |
Brugia malayi | Hexokinase family protein | 0.0211 | 0.2479 | 0.2356 |
Entamoeba histolytica | hexokinase 1 | 0.0337 | 0.5195 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0337 | 0.5195 | 1 |
Echinococcus granulosus | hexokinase | 0.0337 | 0.5195 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.0223 | 0.0123 |
Leishmania major | hexokinase, putative | 0.0337 | 0.5195 | 0.5 |
Brugia malayi | hexokinase | 0.0337 | 0.5195 | 0.5117 |
Echinococcus granulosus | hexokinase type 2 | 0.0337 | 0.5195 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0211 | 0.2479 | 0.4604 |
Leishmania major | hexokinase, putative | 0.0337 | 0.5195 | 0.5 |
Loa Loa (eye worm) | hexokinase type II | 0.0337 | 0.5195 | 1 |
Onchocerca volvulus | 0.0337 | 0.5195 | 1 | |
Entamoeba histolytica | hexokinase 2 | 0.0337 | 0.5195 | 0.5 |
Onchocerca volvulus | 0.0337 | 0.5195 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 2.01 nM | Antagonism of GnRH response in HEK-293 cells expressing human GnRH receptor | ChEMBL. | 16033265 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.