Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.0763217 | 0.516358 | 0.5 |
Mycobacterium ulcerans | carbonic anhydrase | 0.103679 | 0.948004 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0729396 | 0.462996 | 0.896656 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.0763217 | 0.516358 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.103679 | 0.948004 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0729396 | 0.462996 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.0729396 | 0.462996 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0729396 | 0.462996 | 0.5 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0729396 | 0.462996 | 1 |
Leishmania major | carbonic anhydrase family protein, putative | 0.0763217 | 0.516358 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0729396 | 0.462996 | 0.5 |
Plasmodium falciparum | carbonic anhydrase | 0.0435949 | 0 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0729396 | 0.462996 | 0.462996 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0729396 | 0.462996 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0729396 | 0.462996 | 0.896656 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0729396 | 0.462996 | 1 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.0828153 | 0.618813 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.0763217 | 0.516358 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.103679 | 0.948004 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0435949 | 0 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0554575 | 0.187166 | 0.0414155 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0729396 | 0.462996 | 0.462996 |
Loa Loa (eye worm) | hypothetical protein | 0.106975 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | < 10 mg kg-1 | 50% effective dose against Plasmodium yoelii in mice | ChEMBL. | 11855985 |
ED50 (functional) | < 10 mg kg-1 | Antimalarial activity against chloroquine-resistant Plasmodium yoelii infected in po dosed mouse | ChEMBL. | No reference |
ED90 (functional) | > 10 mg kg-1 | 90% effective dose against Plasmodium yoelii in mice | ChEMBL. | 11855985 |
IC50 (functional) | = 3.15 nM | In vitro inhibitory concentration against the K-1 chloroquine-resistant strain of Plasmodium falciparum | ChEMBL. | 11855985 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 11855985 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.