Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | casein kinase ii subunit alpha | 0.0077 | 0.1039 | 0.1913 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0137 | 0.3803 | 1 |
Plasmodium falciparum | casein kinase 2, alpha subunit | 0.0077 | 0.1039 | 0.5 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0137 | 0.3803 | 1 |
Onchocerca volvulus | 0.0054 | 0 | 0.5 | |
Entamoeba histolytica | protein kinase domain containing protein | 0.0077 | 0.1039 | 0.5 |
Plasmodium vivax | unspecified product | 0.0077 | 0.1039 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0106 | 0.0106 |
Onchocerca volvulus | 0.0054 | 0 | 0.5 | |
Onchocerca volvulus | 0.0054 | 0 | 0.5 | |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0056 | 0.0106 | 0.0196 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0137 | 0.3803 | 0.5 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0054 | 0 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0077 | 0.1039 | 1 |
Schistosoma mansoni | patched 1 | 0.0056 | 0.0106 | 0.0196 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0077 | 0.1039 | 1 |
Onchocerca volvulus | 0.0054 | 0 | 0.5 | |
Loa Loa (eye worm) | STAT protein | 0.0272 | 1 | 1 |
Echinococcus multilocularis | protein patched | 0.0056 | 0.0106 | 0.0196 |
Echinococcus multilocularis | protein dispatched 1 | 0.0056 | 0.0106 | 0.0196 |
Onchocerca volvulus | 0.0054 | 0 | 0.5 | |
Onchocerca volvulus | 0.0054 | 0 | 0.5 | |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0056 | 0.0106 | 0.0196 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0077 | 0.1039 | 1 |
Brugia malayi | Casein kinase II, alpha chain | 0.0077 | 0.1039 | 0.1039 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0077 | 0.1039 | 1 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0137 | 0.3803 | 0.7001 |
Brugia malayi | Hydroxymethylglutaryl-coenzyme A reductase family protein | 0.0137 | 0.3803 | 0.3803 |
Onchocerca volvulus | 0.0054 | 0 | 0.5 | |
Onchocerca volvulus | 0.0054 | 0 | 0.5 | |
Onchocerca volvulus | 0.0054 | 0 | 0.5 | |
Onchocerca volvulus | 0.0054 | 0 | 0.5 | |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0056 | 0.0106 | 0.0196 |
Loa Loa (eye worm) | CMGC/CK2 protein kinase | 0.0077 | 0.1039 | 0.1039 |
Onchocerca volvulus | 0.0054 | 0 | 0.5 | |
Giardia lamblia | Kinase, CMGC CK2 | 0.0077 | 0.1039 | 1 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0137 | 0.3803 | 0.7001 |
Onchocerca volvulus | 0.0054 | 0 | 0.5 | |
Entamoeba histolytica | casein kinase, putative | 0.0077 | 0.1039 | 0.5 |
Onchocerca volvulus | 0.0054 | 0 | 0.5 | |
Echinococcus granulosus | Protein patched homolog 1 | 0.0056 | 0.0106 | 0.0196 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0077 | 0.1039 | 1 |
Brugia malayi | CHE-14 protein | 0.0056 | 0.0106 | 0.0106 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0056 | 0.0106 | 0.0106 |
Toxoplasma gondii | CMGC kinase, CK2 family | 0.0077 | 0.1039 | 0.5 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0137 | 0.3803 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0077 | 0.1039 | 1 |
Echinococcus multilocularis | geminin | 0.0172 | 0.5432 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0064 | 0.0467 | 0.3869 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0056 | 0.0106 | 0.0196 |
Onchocerca volvulus | 0.0054 | 0 | 0.5 | |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0064 | 0.0467 | 0.3869 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0054 | 0 | 0.5 |
Schistosoma mansoni | protein kinase | 0.0077 | 0.1039 | 0.1913 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.5432 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0064 | 0.0467 | 0.3869 |
Echinococcus multilocularis | casein kinase ii subunit alpha | 0.0077 | 0.1039 | 0.1913 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0056 | 0.0106 | 0.0196 |
Onchocerca volvulus | 0.0054 | 0 | 0.5 | |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0137 | 0.3803 | 0.7001 |
Echinococcus granulosus | geminin | 0.0172 | 0.5432 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.5432 | 1 |
Onchocerca volvulus | 0.0054 | 0 | 0.5 | |
Onchocerca volvulus | 0.0054 | 0 | 0.5 | |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0137 | 0.3803 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.3803 | 0.3803 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0077 | 0.1039 | 1 |
Plasmodium vivax | casein kinase 2, alpha subunit, putative | 0.0077 | 0.1039 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 14.91 uM | Antifungal activity against Candida albicans using twofold microbroth dilution technique. | ChEMBL. | 10969966 |
MIC (functional) | = 14.63 uM | Lowest concentration of compound that substantially inhibited the growth of Cryptococcus neoformans after 48 hr | ChEMBL. | 10969966 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Candida albicans | ChEMBL23 | 10969966 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.