TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 656.727 | Formula: C32H44N6O9
H donors: 9 H acceptors: 9 LogP: -0.85 Rotable bonds: 23
Rule of 5 violations (Lipinski): 3
SMILES: NCCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)CC(=O)N)Cc1ccccc1)[C@H](CC)C)NC(=O)c1cc(O)ccc1O
InChi: 1S/C32H44N6O9/c1-3-18(2)27(38-29(43)22(11-7-8-14-33)35-28(42)21-16-20(39)12-13-25(21)40)31(45)36-23(15-19-9-5-4-6-10-19)30(44)37-24(32(46)47)17-26(34)41/h4-6,9-10,12-13,16,18,22-24,27,39-40H,3,7-8,11,14-15,17,33H2,1-2H3,(H2,34,41)(H,35,42)(H,36,45)(H,37,44)(H,38,43)(H,46,47)/t18-,22-,23-,24-,27-/m0/s1
InChiKey: AOFIIRBNRCTWMC-QSFSQKMHSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0458	0.1264	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0458	0.1264	0.1264
Schistosoma mansoni	histamine h1 receptor	0.0458	0.1264	0.1264
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0079	0.0127	0.0127
Onchocerca volvulus		0.0251	0.0645	0.51
Loa Loa (eye worm)	hypothetical protein	0.0458	0.1264	1
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0079	0.0127	0.1003
Brugia malayi	Kringle domain containing protein	0.0044	0.0022	0.0177
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0458	0.1264	1
Onchocerca volvulus		0.0085	0.0146	0.1152
Entamoeba histolytica	protein kinase , putative	0.0057	0.0063	1
Schistosoma mansoni	biogenic amine receptor	0.0458	0.1264	0.1264
Echinococcus multilocularis	neuropeptides capa receptor	0.0458	0.1264	0.1264
Echinococcus granulosus	neuropeptide receptor A26	0.0458	0.1264	0.1264
Echinococcus multilocularis	dro:myosuppressin receptor	0.0458	0.1264	0.1264
Echinococcus multilocularis	serotonin receptor	0.0458	0.1264	0.1264
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0251	0.0645	0.0645
Schistosoma mansoni	cercarial elastase (S01 family)	0.006	0.0071	0.0071
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0458	0.1264	0.1264
Brugia malayi	AKH receptor	0.0458	0.1264	1
Trichomonas vaginalis	AGC family protein kinase	0.0057	0.0063	0.5
Brugia malayi	PAN domain containing protein	0.0085	0.0146	0.1152
Echinococcus multilocularis	g protein coupled receptor	0.0458	0.1264	0.1264
Loa Loa (eye worm)	hypothetical protein	0.0458	0.1264	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0458	0.1264	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0127	0.1003
Echinococcus granulosus	rhodopsin orphan GPCR	0.0458	0.1264	0.1264
Brugia malayi	Serotonin receptor	0.0458	0.1264	1
Loa Loa (eye worm)	hypothetical protein	0.0458	0.1264	1
Onchocerca volvulus		0.0042	0.0018	0.0142
Onchocerca volvulus		0.006	0.0071	0.0563
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0079	0.0127	0.1003
Schistosoma mansoni	hypothetical protein	0.0458	0.1264	0.1264
Loa Loa (eye worm)	hypothetical protein	0.0458	0.1264	1
Toxoplasma gondii	PAN domain-containing protein	0.0907	0.2613	1
Onchocerca volvulus		0.0458	0.1264	1
Loa Loa (eye worm)	hypothetical protein	0.0458	0.1264	1
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0079	0.0127	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0458	0.1264	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0127	0.1003
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.006	0.0071	0.0071
Brugia malayi	Cation transporter family protein	0.0079	0.0127	0.1003
Toxoplasma gondii	PAN domain-containing protein	0.0085	0.0146	0.0476
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0458	0.1264	1
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0146	0.1152
Loa Loa (eye worm)	hypothetical protein	0.0458	0.1264	1
Brugia malayi	PAN domain containing protein	0.0085	0.0146	0.1152
Echinococcus multilocularis	neuropeptide receptor	0.0458	0.1264	0.1264
Loa Loa (eye worm)	PAN domain-containing protein	0.0085	0.0146	0.1152
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0127	0.1003
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0458	0.1264	0.1264
Echinococcus granulosus	ephrin type A receptor 4 A	0.0063	0.008	0.008
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0079	0.0127	0.1003
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0079	0.0127	0.1003
Onchocerca volvulus		0.006	0.0071	0.0563
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0458	0.1264	0.1264
Schistosoma mansoni	hypothetical protein	0.006	0.0071	0.0071
Trichomonas vaginalis	AGC family protein kinase	0.0057	0.0063	0.5
Onchocerca volvulus		0.006	0.0071	0.0563
Brugia malayi	PAN domain containing protein	0.0085	0.0146	0.1152
Schistosoma mansoni	neuropeptide receptor	0.3371	1	1
Loa Loa (eye worm)	hypothetical protein	0.0458	0.1264	1
Loa Loa (eye worm)	hypothetical protein	0.0215	0.0536	0.4239
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0127	0.1003
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0458	0.1264	0.1264
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0018	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0458	0.1264	1
Onchocerca volvulus		0.0458	0.1264	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0458	0.1264	0.1264
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0458	0.1264	0.1264
Onchocerca volvulus		0.0085	0.0146	0.1152
Schistosoma mansoni	cercarial elastase (S01 family)	0.006	0.0071	0.0071
Onchocerca volvulus		0.0085	0.0146	0.1152
Loa Loa (eye worm)	PAN domain-containing protein	0.0085	0.0146	0.1152
Loa Loa (eye worm)	hypothetical protein	0.006	0.0071	0.0563
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0458	0.1264	1
Loa Loa (eye worm)	PAN domain-containing protein	0.0085	0.0146	0.1152
Onchocerca volvulus		0.0079	0.0127	0.1003
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0063	0.008	0.008
Onchocerca volvulus		0.0085	0.0146	0.1152
Loa Loa (eye worm)	G-protein coupled receptor	0.0458	0.1264	1
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0147	0.0332	0.0332
Loa Loa (eye worm)	hypothetical protein	0.006	0.0071	0.0563
Echinococcus granulosus	transmembrane protease serine 3	0.006	0.0071	0.0071
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0458	0.1264	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.0071	0.0563
Brugia malayi	sulfakinin receptor protein	0.0458	0.1264	1
Loa Loa (eye worm)	LGC-31 protein	0.0079	0.0127	0.1003
Loa Loa (eye worm)	hypothetical protein	0.0458	0.1264	1
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0147	0.0332	0.0332
Echinococcus granulosus	g protein coupled receptor	0.0458	0.1264	0.1264
Schistosoma mansoni	neuropeptide f receptor 76f	0.0458	0.1264	0.1264
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0458	0.1264	0.1264
Onchocerca volvulus		0.0458	0.1264	1
Echinococcus granulosus	g-protein coupled receptor	0.0458	0.1264	0.1264
Echinococcus granulosus	enteropeptidase	0.006	0.0071	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0146	0.1152
Brugia malayi	hypothetical protein	0.0458	0.1264	1
Loa Loa (eye worm)	hypothetical protein	0.0458	0.1264	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0458	0.1264	0.1264
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0458	0.1264	0.1264
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0079	0.0127	0.0127
Loa Loa (eye worm)	TK/ROR protein kinase	0.0044	0.0024	0.0193
Echinococcus granulosus	somatostatin receptor	0.0458	0.1264	0.1264
Toxoplasma gondii	microneme protein MIC17A	0.0085	0.0146	0.0476
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.006	0.0071	0.0071
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0079	0.0127	0.0127
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0458	0.1264	0.1264
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.006	0.0071	0.0071
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0458	0.1264	0.1264
Echinococcus granulosus	tm gpcr rhodopsin	0.0458	0.1264	0.1264
Brugia malayi	Dopamine receptor	0.0458	0.1264	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0079	0.0127	0.1003
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0127	0.1003
Brugia malayi	RE15519p	0.0458	0.1264	1
Echinococcus multilocularis	orexin receptor type 2	0.0458	0.1264	0.1264
Loa Loa (eye worm)	melatonin receptor type 1A	0.0458	0.1264	1
Echinococcus granulosus	nAChR subunit	0.0042	0.0018	0.0018
Toxoplasma gondii	subtilisin SUB12	0.0085	0.0146	0.0476
Loa Loa (eye worm)	G-protein coupled receptor	0.0458	0.1264	1
Toxoplasma gondii	microneme protein MIC4	0.0085	0.0146	0.0476
Loa Loa (eye worm)	hypothetical protein	0.0458	0.1264	1
Loa Loa (eye worm)	AUR protein kinase	0.0057	0.0063	0.0497
Loa Loa (eye worm)	ACC-1 protein	0.0079	0.0127	0.1003
Echinococcus granulosus	orexin receptor type 2	0.0458	0.1264	0.1264
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0458	0.1264	0.1264
Schistosoma mansoni	cercarial elastase (S01 family)	0.006	0.0071	0.0071
Leishmania major	protein kinase, putative	0.0057	0.0063	1
Schistosoma mansoni	opsin-like receptor	0.0458	0.1264	0.1264
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0079	0.0127	0.0127
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0458	0.1264	1
Brugia malayi	Trypsin-like protease protein 5	0.006	0.0071	0.0563
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0079	0.0127	0.1003
Loa Loa (eye worm)	hypothetical protein	0.0458	0.1264	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0458	0.1264	1
Echinococcus granulosus	glycine receptor subunit beta	0.0079	0.0127	0.0127
Onchocerca volvulus		0.0458	0.1264	1
Loa Loa (eye worm)	hypothetical protein	0.0251	0.0645	0.51
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.006	0.0071	0.0071
Schistosoma mansoni	hypothetical protein	0.0458	0.1264	0.1264
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0458	0.1264	0.1264
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0458	0.1264	0.1264
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0458	0.1264	0.1264
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0458	0.1264	0.1264
Echinococcus multilocularis	aurora kinase A	0.0057	0.0063	0.0063
Schistosoma mansoni	hypothetical protein	0.0044	0.0022	0.0022
Echinococcus granulosus	rhodopsin orphan GPCR	0.0458	0.1264	0.1264
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0458	0.1264	1
Schistosoma mansoni	hypothetical protein	0.0458	0.1264	0.1264
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0251	0.0645	0.0645
Brugia malayi	hypothetical protein	0.0458	0.1264	1
Loa Loa (eye worm)	hypothetical protein	0.0458	0.1264	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0458	0.1264	0.1264
Onchocerca volvulus		0.0079	0.0127	0.1003
Echinococcus granulosus	biogenic amine 5HT receptor	0.0458	0.1264	0.1264
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0042	0.0018	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0458	0.1264	1
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0147	0.0332	0.2629
Brugia malayi	putative neuropeptide receptor	0.0458	0.1264	1
Brugia malayi	hypothetical protein	0.0458	0.1264	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0458	0.1264	0.1264
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0147	0.0332	0.0332
Schistosoma mansoni	cercarial elastase (S01 family)	0.006	0.0071	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0458	0.1264	1
Loa Loa (eye worm)	hypothetical protein	0.0251	0.0645	0.51
Echinococcus granulosus	neuropeptide s receptor	0.0458	0.1264	0.1264
Schistosoma mansoni	amine GPCR	0.0458	0.1264	0.1264
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0079	0.0127	0.1003
Loa Loa (eye worm)	hypothetical protein	0.0458	0.1264	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0458	0.1264	0.1264
Echinococcus multilocularis	g protein coupled receptor	0.0458	0.1264	0.1264
Loa Loa (eye worm)	hypothetical protein	0.0458	0.1264	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0458	0.1264	0.1264
Onchocerca volvulus		0.0458	0.1264	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0018	0.0142
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0147	0.0332	0.2629
Loa Loa (eye worm)	hypothetical protein	0.0458	0.1264	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0458	0.1264	0.1264
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0042	0.0018	0.0142
Schistosoma mansoni	protein kinase	0.0057	0.0063	0.0063
Onchocerca volvulus		0.006	0.0071	0.0563
Loa Loa (eye worm)	ACC-1 protein	0.0079	0.0127	0.1003
Echinococcus multilocularis	neuropeptide receptor	0.3371	1	1
Schistosoma mansoni	nAChR subunit	0.0079	0.0127	0.0127
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0147	0.0332	0.0332
Schistosoma mansoni	serine/threonine protein kinase	0.0057	0.0063	0.0063
Schistosoma mansoni	adenoreceptor	0.0458	0.1264	0.1264
Brugia malayi	G-protein coupled receptor	0.0458	0.1264	1
Schistosoma mansoni	neuropeptide receptor	0.0458	0.1264	0.1264
Toxoplasma gondii	microneme protein, putative	0.0085	0.0146	0.0476
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0127	0.1003
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0458	0.1264	0.1264
Schistosoma mansoni	nAChR subunit	0.0079	0.0127	0.0127
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0079	0.0127	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0127	0.1003
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0458	0.1264	0.1264
Schistosoma mansoni	hypothetical protein	0.006	0.0071	0.0071
Echinococcus granulosus	Mastin	0.006	0.0071	0.0071
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0057	0.0063	1
Loa Loa (eye worm)	hypothetical protein	0.0458	0.1264	1
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0079	0.0127	0.0127
Onchocerca volvulus		0.0085	0.0146	0.1152
Loa Loa (eye worm)	hypothetical protein	0.0458	0.1264	1
Loa Loa (eye worm)	hypothetical protein	0.0458	0.1264	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0458	0.1264	1
Brugia malayi	neuropeptide F receptor	0.0458	0.1264	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0458	0.1264	0.1264
Schistosoma mansoni	myosin xvIII	0.0458	0.1264	0.1264
Echinococcus granulosus	sex peptide receptor	0.0458	0.1264	0.1264
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0458	0.1264	0.1264
Echinococcus granulosus	g protein coupled receptor	0.0458	0.1264	0.1264
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.006	0.0071	0.0071
Brugia malayi	G protein-coupled receptor F59B2.13	0.0458	0.1264	1
Toxoplasma gondii	microneme protein MIC17C	0.0085	0.0146	0.0476
Giardia lamblia	Aurora kinase	0.0057	0.0063	0.5
Toxoplasma gondii	PAN domain-containing protein	0.0085	0.0146	0.0476
Echinococcus granulosus	neuropeptide FF receptor 2	0.0458	0.1264	0.1264
Schistosoma mansoni	cercarial elastase (S01 family)	0.006	0.0071	0.0071
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0042	0.0018	0.0018
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0458	0.1264	0.1264
Brugia malayi	hypothetical protein	0.0458	0.1264	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0458	0.1264	0.1264
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0147	0.0332	0.0332
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0458	0.1264	0.1264
Onchocerca volvulus		0.0085	0.0146	0.1152
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0458	0.1264	1
Echinococcus multilocularis	sex peptide receptor	0.0458	0.1264	0.1264
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0458	0.1264	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0458	0.1264	0.1264
Onchocerca volvulus		0.0458	0.1264	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.006	0.0071	0.0071
Schistosoma mansoni	cercarial elastase (S01 family)	0.006	0.0071	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0458	0.1264	1
Echinococcus granulosus	hypothetical protein	0.0458	0.1264	0.1264
Onchocerca volvulus		0.0044	0.0022	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0458	0.1264	1
Loa Loa (eye worm)	hypothetical protein	0.0458	0.1264	1
Brugia malayi	serine/threonine-protein kinase 6	0.0057	0.0063	0.0497
Echinococcus multilocularis	nAChR subunit	0.0079	0.0127	0.0127
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0458	0.1264	0.1264
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0458	0.1264	0.1264
Brugia malayi	hypothetical protein	0.0458	0.1264	1
Onchocerca volvulus		0.0251	0.0645	0.51
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0018	0.0142
Echinococcus granulosus	rhodopsin orphan GPCR	0.0458	0.1264	0.1264
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0127	0.1003
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0079	0.0127	0.0127
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0458	0.1264	0.1264
Brugia malayi	Serotonin receptor	0.0458	0.1264	1
Toxoplasma gondii	PAN domain-containing protein	0.0085	0.0146	0.0476
Brugia malayi	Trypsin family protein	0.0316	0.0838	0.6628
Brugia malayi	Dopamine receptor protein 2	0.0458	0.1264	1
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0057	0.0063	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0458	0.1264	0.1264
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0079	0.0127	0.0127
Schistosoma mansoni	neuropeptide receptor	0.0458	0.1264	0.1264
Schistosoma mansoni	amine GPCR	0.0458	0.1264	0.1264
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0018	0.0142
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0079	0.0127	0.1003
Toxoplasma gondii	1,3(4)-beta-glucanase	0.0085	0.0146	0.0476
Echinococcus granulosus	g protein coupled receptor	0.0458	0.1264	0.1264
Echinococcus granulosus	aurora kinase A	0.0057	0.0063	0.0063
Brugia malayi	serine/threonine kinase 12	0.0057	0.0063	0.0497
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0458	0.1264	0.1264
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0458	0.1264	0.1264
Onchocerca volvulus		0.0251	0.0645	0.51
Brugia malayi	Dopamine receptor protein 1	0.0458	0.1264	1
Echinococcus multilocularis	fmrfamide receptor	0.0458	0.1264	0.1264
Loa Loa (eye worm)	hypothetical protein	0.0458	0.1264	1
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0079	0.0127	0.1003
Loa Loa (eye worm)	PAN domain-containing protein	0.0085	0.0146	0.1152
Brugia malayi	PAN domain containing protein	0.0085	0.0146	0.1152
Brugia malayi	follicle stimulating hormone receptor	0.0458	0.1264	1
Echinococcus granulosus	neuropeptides capa receptor	0.0458	0.1264	0.1264
Echinococcus granulosus	7TM GPCR rhodopsin	0.0458	0.1264	0.1264
Echinococcus granulosus	tm gpcr rhodopsin	0.1989	0.5856	0.5856
Schistosoma mansoni	nAChR subunit	0.0079	0.0127	0.0127
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0458	0.1264	0.1264
Schistosoma mansoni	nAChR subunit	0.0079	0.0127	0.0127
Toxoplasma gondii	PAN domain-containing protein	0.0085	0.0146	0.0476
Brugia malayi	G protein-coupled receptor	0.0458	0.1264	1
Schistosoma mansoni	amine GPCR	0.0458	0.1264	0.1264
Echinococcus granulosus	allatostatin A receptor	0.0458	0.1264	0.1264
Schistosoma mansoni	opsin-like receptor	0.0458	0.1264	0.1264
Loa Loa (eye worm)	hypothetical protein	0.0458	0.1264	1
Onchocerca volvulus		0.006	0.0071	0.0563
Onchocerca volvulus		0.0458	0.1264	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0458	0.1264	0.1264
Brugia malayi	Trypsin family protein	0.006	0.0071	0.0563
Echinococcus granulosus	nAChR subunit	0.0079	0.0127	0.0127
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0079	0.0127	0.1003
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0127	0.1003
Echinococcus granulosus	G protein coupled receptor 139	0.0458	0.1264	0.1264
Loa Loa (eye worm)	hypothetical protein	0.0458	0.1264	1
Echinococcus multilocularis	somatostatin receptor	0.0458	0.1264	0.1264
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0458	0.1264	1
Loa Loa (eye worm)	hypothetical protein	0.0458	0.1264	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0018	0.0142
Echinococcus granulosus	rhodopsin orphan GPCR	0.0458	0.1264	0.1264
Brugia malayi	ORL1-like opioid receptor	0.0458	0.1264	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0458	0.1264	0.1264
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0458	0.1264	0.1264
Onchocerca volvulus		0.0458	0.1264	1
Toxoplasma gondii	hypothetical protein	0.0085	0.0146	0.0476
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0018	0.0142
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0458	0.1264	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0458	0.1264	0.1264
Brugia malayi	Protein kinase domain containing protein	0.0044	0.0024	0.0193
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0079	0.0127	0.0127
Onchocerca volvulus		0.0458	0.1264	1
Loa Loa (eye worm)	hypothetical protein	0.0458	0.1264	1
Entamoeba histolytica	protein kinase, putative	0.0057	0.0063	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0127	0.1003
Loa Loa (eye worm)	hypothetical protein	0.0458	0.1264	1
Schistosoma mansoni	neurotransmitter gated ion channel	0.0042	0.0018	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0458	0.1264	1
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0079	0.0127	0.1003
Echinococcus granulosus	dro:myosuppressin receptor	0.0458	0.1264	0.1264
Brugia malayi	hypothetical protein	0.0458	0.1264	1
Echinococcus multilocularis	serotonin receptor	0.0458	0.1264	0.1264
Echinococcus granulosus	neuropeptide Y receptor	0.0458	0.1264	0.1264
Loa Loa (eye worm)	hypothetical protein	0.0458	0.1264	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0458	0.1264	0.1264
Echinococcus multilocularis	neuropeptide Y receptor	0.0458	0.1264	0.1264
Echinococcus multilocularis	tissue type plasminogen activator	0.0044	0.0022	0.0022
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0458	0.1264	0.1264
Loa Loa (eye worm)	TYRA-2 protein	0.0458	0.1264	1
Echinococcus granulosus	fmrfamide receptor	0.0458	0.1264	0.1264
Brugia malayi	G-protein coupled receptor	0.0458	0.1264	1
Brugia malayi	serine/threonine protein kinase 6	0.0057	0.0063	0.0497
Onchocerca volvulus	Putative nachr subunit	0.0147	0.0332	0.2629
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0079	0.0127	0.1003
Brugia malayi	PAN domain containing protein	0.0085	0.0146	0.1152
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0146	0.1152
Echinococcus granulosus	tm gpcr rhodopsin	0.0458	0.1264	0.1264
Brugia malayi	PAN domain containing protein	0.0085	0.0146	0.1152
Brugia malayi	PAN domain containing protein	0.0085	0.0146	0.1152
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0079	0.0127	0.0127
Trypanosoma cruzi	aurora B kinase, putative	0.0057	0.0063	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0458	0.1264	0.1264
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.006	0.0071	0.0071
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0316	0.0838	0.0838
Schistosoma mansoni	opsin-like receptor	0.0458	0.1264	0.1264
Trichomonas vaginalis	AGC family protein kinase	0.0057	0.0063	0.5
Echinococcus multilocularis	glycoprotein Antigen 5	0.006	0.0071	0.0071
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0079	0.0127	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0127	0.1003
Onchocerca volvulus		0.0458	0.1264	1
Echinococcus granulosus	neuropeptides capa receptor	0.0458	0.1264	0.1264
Loa Loa (eye worm)	hypothetical protein	0.0458	0.1264	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0458	0.1264	0.1264
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.006	0.0071	0.0071
Brugia malayi	hypothetical protein	0.0458	0.1264	1
Toxoplasma gondii	PAN/Apple domain-containing protein	0.0085	0.0146	0.0476
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0057	0.0063	1
Brugia malayi	GnHR receptor homolog	0.0458	0.1264	1
Brugia malayi	putative neuropeptide receptor NPR1	0.0458	0.1264	1
Schistosoma mansoni	nAChR subunit	0.0079	0.0127	0.0127
Brugia malayi	PAN domain containing protein	0.0085	0.0146	0.1152
Echinococcus granulosus	glycine receptor subunit beta	0.0079	0.0127	0.0127
Brugia malayi	Cation transporter family protein	0.0079	0.0127	0.1003
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0079	0.0127	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0127	0.1003
Mycobacterium ulcerans	hypothetical protein	0.006	0.0071	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0458	0.1264	0.1264
Brugia malayi	PAN domain containing protein	0.0085	0.0146	0.1152
Echinococcus multilocularis	neuropeptide s receptor	0.0458	0.1264	0.1264
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0079	0.0127	0.0127
Echinococcus granulosus	tissue type plasminogen activator	0.0044	0.0022	0.0022
Toxoplasma gondii	hypothetical protein	0.0085	0.0146	0.0476
Echinococcus multilocularis	transmembrane protease serine 3	0.006	0.0071	0.0071
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0458	0.1264	0.1264
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0022	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0316	0.0838	0.6628
Loa Loa (eye worm)	trypsin family protein	0.006	0.0071	0.0563
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.006	0.0071	0.0563
Onchocerca volvulus		0.0085	0.0146	0.1152
Brugia malayi	Trypsin family protein	0.006	0.0071	0.0563
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0042	0.0018	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0127	0.1003
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0079	0.0127	0.1003
Brugia malayi	larval opioid receptor	0.0458	0.1264	1
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0079	0.0127	0.0127
Brugia malayi	Cation transporter family protein	0.0251	0.0645	0.51
Loa Loa (eye worm)	hypothetical protein	0.0316	0.0838	0.6628
Schistosoma mansoni	amine GPCR	0.0458	0.1264	0.1264
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0042	0.0018	0.0018
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0458	0.1264	0.1264
Echinococcus multilocularis	Mastin	0.006	0.0071	0.0071
Toxoplasma gondii	aurora kinase	0.0057	0.0063	0.0156
Schistosoma mansoni	amine GPCR	0.0458	0.1264	0.1264
Loa Loa (eye worm)	hypothetical protein	0.0458	0.1264	1
Loa Loa (eye worm)	PAN domain-containing protein	0.0085	0.0146	0.1152
Echinococcus granulosus	rhodopsin orphan GPCR	0.0458	0.1264	0.1264
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0458	0.1264	0.1264
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0079	0.0127	0.1003
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0057	0.0063	0.0063
Toxoplasma gondii	microneme protein MIC17B	0.0085	0.0146	0.0476
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0458	0.1264	1
Brugia malayi	excitatory GABA receptor EXP-1A	0.0079	0.0127	0.1003
Loa Loa (eye worm)	hypothetical protein	0.0458	0.1264	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0018	0.0142
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0458	0.1264	0.1264
Loa Loa (eye worm)	AUR protein kinase	0.0057	0.0063	0.0497
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0057	0.0063	0.0063
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.006	0.0071	0.0071
Schistosoma mansoni	nAChR subunit	0.0079	0.0127	0.0127
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0458	0.1264	0.1264
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0458	0.1264	0.1264
Schistosoma mansoni	cercarial elastase (S01 family)	0.006	0.0071	0.0071
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0458	0.1264	0.1264
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0146	0.1152
Echinococcus multilocularis	G protein coupled receptor 139	0.3371	1	1
Onchocerca volvulus		0.0458	0.1264	1
Echinococcus multilocularis	allatostatin A receptor	0.0458	0.1264	0.1264
Onchocerca volvulus		0.0079	0.0127	0.1003
Onchocerca volvulus		0.0085	0.0146	0.1152
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0079	0.0127	0.1003
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0147	0.0332	0.0332
Onchocerca volvulus		0.0316	0.0838	0.6628
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0458	0.1264	1
Loa Loa (eye worm)	hypothetical protein	0.0458	0.1264	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0458	0.1264	0.1264
Echinococcus granulosus	neuropeptide Y receptor	0.0458	0.1264	0.1264
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0458	0.1264	0.1264
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0458	0.1264	0.1264
Echinococcus multilocularis	glycine receptor subunit beta	0.0079	0.0127	0.0127
Onchocerca volvulus		0.0256	0.0658	0.5203
Schistosoma mansoni	cercarial elastase (S01 family)	0.006	0.0071	0.0071
Onchocerca volvulus		0.0042	0.0018	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0146	0.1152
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0458	0.1264	0.1264
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.032	0.0852	0.0852
Echinococcus multilocularis	g protein coupled receptor	0.0458	0.1264	0.1264
Loa Loa (eye worm)	hypothetical protein	0.0458	0.1264	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0458	0.1264	0.1264
Schistosoma mansoni	ephrin receptor	0.0063	0.008	0.008
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0018	0.0142
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0057	0.0063	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.0071	0.0563
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0079	0.0127	0.1003
Loa Loa (eye worm)	hypothetical protein	0.0458	0.1264	1
Onchocerca volvulus		0.0458	0.1264	1
Onchocerca volvulus		0.0085	0.0146	0.1152
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.006	0.0071	0.0071
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.1989	0.5856	0.5856
Schistosoma mansoni	growth hormone secretagogue receptor	0.0458	0.1264	0.1264
Entamoeba histolytica	protein kinase, putative	0.0057	0.0063	1
Loa Loa (eye worm)	TK/EPH protein kinase	0.008	0.0131	0.1038
Onchocerca volvulus		0.0458	0.1264	1
Schistosoma mansoni	hypothetical protein	0.0458	0.1264	0.1264
Loa Loa (eye worm)	hypothetical protein	0.0458	0.1264	1
Brugia malayi	PAN domain containing protein	0.0085	0.0146	0.1152
Schistosoma mansoni	cercarial elastase (S01 family)	0.006	0.0071	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0127	0.1003
Loa Loa (eye worm)	hypothetical protein	0.0458	0.1264	1
Brugia malayi	Melatonin receptor type 1A	0.0458	0.1264	1
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0057	0.0063	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0127	0.1003
Onchocerca volvulus		0.0458	0.1264	1
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0078	0.0617
Toxoplasma gondii	PAN domain-containing protein	0.0907	0.2613	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0458	0.1264	0.1264
Echinococcus multilocularis	enteropeptidase	0.006	0.0071	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0458	0.1264	1
Trypanosoma brucei	aurora B kinase	0.0057	0.0063	0.5
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0458	0.1264	0.1264
Onchocerca volvulus		0.0062	0.0078	0.0617
Schistosoma mansoni	nAChR subunit	0.0079	0.0127	0.0127
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0458	0.1264	0.1264
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0079	0.0127	0.1003
Brugia malayi	Trypsin family protein	0.006	0.0071	0.0563
Entamoeba histolytica	protein kinase domain containing protein	0.0057	0.0063	1
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0332	0.2629
Schistosoma mansoni	biogenic amine receptor	0.0458	0.1264	0.1264
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0146	0.1152
Schistosoma mansoni	biogenic amine receptor	0.0458	0.1264	0.1264
Loa Loa (eye worm)	hypothetical protein	0.0458	0.1264	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0458	0.1264	0.1264
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.006	0.0071	0.0071
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0079	0.0127	0.1003
Schistosoma mansoni	cercarial elastase (S01 family)	0.006	0.0071	0.0071
Brugia malayi	hypothetical protein	0.0458	0.1264	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0458	0.1264	0.1264
Brugia malayi	hypothetical protein	0.0458	0.1264	1
Onchocerca volvulus		0.0085	0.0146	0.1152
Echinococcus granulosus	serotonin receptor	0.0458	0.1264	0.1264
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0458	0.1264	0.1264
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0458	0.1264	0.1264
Onchocerca volvulus		0.0085	0.0146	0.1152
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0079	0.0127	0.0127
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0079	0.0127	0.0127
Onchocerca volvulus		0.0458	0.1264	1
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0079	0.0127	0.0127
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0458	0.1264	0.1264
Brugia malayi	neuropeptide F receptor	0.0458	0.1264	1
Brugia malayi	hypothetical protein	0.006	0.0071	0.0563
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0079	0.0127	0.1003
Loa Loa (eye worm)	hypothetical protein	0.0458	0.1264	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0079	0.0127	0.1003
Onchocerca volvulus		0.0458	0.1264	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.0071	0.0563
Loa Loa (eye worm)	AUR protein kinase	0.0057	0.0063	0.0497
Echinococcus multilocularis	nAChR subunit	0.0042	0.0018	0.0018
Echinococcus multilocularis	glycine receptor subunit beta	0.0079	0.0127	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0127	0.1003
Loa Loa (eye worm)	GABA receptor subunit	0.0042	0.0018	0.0142
Brugia malayi	hypothetical protein	0.0458	0.1264	1
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0146	0.1152
Trichomonas vaginalis	AGC family protein kinase	0.0057	0.0063	0.5
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0042	0.0018	0.0142
Echinococcus multilocularis	g-protein coupled receptor	0.0458	0.1264	0.1264
Echinococcus granulosus	neuropeptide receptor	0.0458	0.1264	0.1264
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0079	0.0127	0.0127
Echinococcus multilocularis	fmrfamide receptor	0.0458	0.1264	0.1264
Schistosoma mansoni	neuropeptide receptor	0.0458	0.1264	0.1264
Loa Loa (eye worm)	hypothetical protein	0.0458	0.1264	1
Echinococcus granulosus	glycoprotein Antigen 5	0.006	0.0071	0.0071

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 21 uM	Anti-thrombin activity by competitive enzyme assay using the fluorogenic substrate Tos-Gly-Pro-Arg-AMC at pH 8.3.	ChEMBL.	9873411

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2372665

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1746785